Adrenal tumors - Revision history

Mikael Häggström: noinclude

2022-11-17T17:51:53Z

noinclude

← Older revision		Revision as of 13:51, 17 November 2022
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	[[File:Incidences and prognoses of adrenal tumors.png\|thumb\|280px\|Incidences and prognoses of adrenal tumors.<ref>Data and references for pie chart are located at [https://commons.wikimedia.org/wiki/File:Incidences_and_prognoses_of_adrenal_tumors.png file description page in Wikimedia Commons.]</ref>]]		[[File:Incidences and prognoses of adrenal tumors.png\|thumb\|280px\|Incidences and prognoses of adrenal tumors.<ref>Data and references for pie chart are located at [https://commons.wikimedia.org/wiki/File:Incidences_and_prognoses_of_adrenal_tumors.png file description page in Wikimedia Commons.]</ref>]]

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	==Reporting==		==Reporting==
	{{CAP}}		{{CAP}}<noinclude>
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Mikael Häggström: /* Adenoma versus carcinoma */ Bolded

2022-04-14T12:47:46Z

Adenoma versus carcinoma: Bolded

← Older revision		Revision as of 08:47, 14 April 2022
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	File:Adrenal gland Conn syndrome4.jpg\|Gross pathology of '''adrenocortical adenoma'''.		File:Adrenal gland Conn syndrome4.jpg\|Gross pathology of '''adrenocortical adenoma'''.
	File:Zona fasciculata versus adrenocortical adenoma.jpg\|Zona fasciculata versus '''adrenocortical adenoma'''. An adrenocortical adenoma typically has mild changes in comparison, including larger cells with larger and more pleomorphic nuclei with more coarse chromatin. H&E stain. {{MH}}		File:Zona fasciculata versus adrenocortical adenoma.jpg\|Zona fasciculata versus '''adrenocortical adenoma'''. An adrenocortical adenoma typically has mild changes in comparison, including larger cells with larger and more pleomorphic nuclei with more coarse chromatin. H&E stain. {{MH}}
	File:Adrenocortical adenoma with focal high grade nuclear atypia.jpg\|Adrenocortical adenoma with focal high grade nuclear atypia.<ref name=Gupta2010/>		File:Adrenocortical adenoma with focal high grade nuclear atypia.jpg\|'''Adrenocortical adenoma''' with focal high grade nuclear atypia.<ref name=Gupta2010/>
	File:Adrenocortical adenoma with focal necrosis.jpg\|Adrenocortical adenoma with focal necrosis<ref name=Gupta2010>{{cite journal\| author=Gupta S, Melendez J, Khanna A\| title=Deoxycorticosterone producing tumor as a cause of resistant hypertension. \| journal=Case Rep Med \| year= 2010 \| volume= 2010 \| issue= \| pages= 372719 \| pmid=20671982 \| doi=10.1155/2010/372719 \| pmc=2909735 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20671982 }}<br>- "This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."</ref>		File:Adrenocortical adenoma with focal necrosis.jpg\|'''Adrenocortical adenoma''' with focal necrosis<ref name=Gupta2010>{{cite journal\| author=Gupta S, Melendez J, Khanna A\| title=Deoxycorticosterone producing tumor as a cause of resistant hypertension. \| journal=Case Rep Med \| year= 2010 \| volume= 2010 \| issue= \| pages= 372719 \| pmid=20671982 \| doi=10.1155/2010/372719 \| pmc=2909735 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20671982 }}<br>- "This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."</ref>
	File:Adrenal cortical carcinoma.JPG\|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.		File:Adrenal cortical carcinoma.JPG\|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.
	File:Histopathology of adrenocortical carcinoma.jpg\|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.		File:Histopathology of adrenocortical carcinoma.jpg\|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.

Mikael Häggström: /* Adenoma versus carcinoma */ +Images

2022-04-14T12:47:02Z

Adenoma versus carcinoma: +Images

← Older revision		Revision as of 08:47, 14 April 2022
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	File:Adrenal gland Conn syndrome4.jpg\|Gross pathology of '''adrenocortical adenoma'''.		File:Adrenal gland Conn syndrome4.jpg\|Gross pathology of '''adrenocortical adenoma'''.
	File:Zona fasciculata versus adrenocortical adenoma.jpg\|Zona fasciculata versus '''adrenocortical adenoma'''. An adrenocortical adenoma typically has mild changes in comparison, including larger cells with larger and more pleomorphic nuclei with more coarse chromatin. H&E stain. {{MH}}		File:Zona fasciculata versus adrenocortical adenoma.jpg\|Zona fasciculata versus '''adrenocortical adenoma'''. An adrenocortical adenoma typically has mild changes in comparison, including larger cells with larger and more pleomorphic nuclei with more coarse chromatin. H&E stain. {{MH}}
			File:Adrenocortical adenoma with focal high grade nuclear atypia.jpg\|Adrenocortical adenoma with focal high grade nuclear atypia.<ref name=Gupta2010/>
			File:Adrenocortical adenoma with focal necrosis.jpg\|Adrenocortical adenoma with focal necrosis<ref name=Gupta2010>{{cite journal\| author=Gupta S, Melendez J, Khanna A\| title=Deoxycorticosterone producing tumor as a cause of resistant hypertension. \| journal=Case Rep Med \| year= 2010 \| volume= 2010 \| issue= \| pages= 372719 \| pmid=20671982 \| doi=10.1155/2010/372719 \| pmc=2909735 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20671982 }}<br>- "This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."</ref>
	File:Adrenal cortical carcinoma.JPG\|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.		File:Adrenal cortical carcinoma.JPG\|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.
	File:Histopathology of adrenocortical carcinoma.jpg\|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.		File:Histopathology of adrenocortical carcinoma.jpg\|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.

Mikael Häggström: /* Adenoma versus carcinoma */ Replaced

2022-04-14T12:34:23Z

Adenoma versus carcinoma: Replaced

← Older revision		Revision as of 08:34, 14 April 2022
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	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Adrenal gland Conn syndrome4.jpg\|Gross pathology of '''adrenocortical adenoma'''.		File:Adrenal gland Conn syndrome4.jpg\|Gross pathology of '''adrenocortical adenoma'''.
	File:~~Histopathology of~~ adrenocortical adenoma.jpg\|~~Histopathology of~~ '''adrenocortical adenoma''', ~~most commonly showing clear~~ cells with ~~high lipid contents~~.~~<ref>~~{{cite journal\|last1=Mete\|first1=Ozgur\|last2=Duan\|first2=Kai\|title=The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity\|journal=Frontiers in Medicine\|volume=5\|year=2018\|issn=2296-858X\|doi=10.3389/fmed.2018.00054}}~~<br>Attribution 4.0 International (CC BY 4.0) license</ref>~~		File:Zona fasciculata versus adrenocortical adenoma.jpg\|Zona fasciculata versus '''adrenocortical adenoma'''. An adrenocortical adenoma typically has mild changes in comparison, including larger cells with larger and more pleomorphic nuclei with more coarse chromatin. H&E stain. {{MH}}
	File:Adrenal cortical carcinoma.JPG\|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.		File:Adrenal cortical carcinoma.JPG\|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.
	File:Histopathology of adrenocortical carcinoma.jpg\|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.		File:Histopathology of adrenocortical carcinoma.jpg\|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.

Mikael Häggström: /* Other adrenal tumors */ Moved

2022-03-01T22:59:38Z

Other adrenal tumors: Moved

← Older revision		Revision as of 18:59, 1 March 2022
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	===Other adrenal tumors===		===Other adrenal tumors===
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Histopathology of a pheochromocytoma ~~with coagulative necrosis, annotated~~.jpg\|~~Histopathology of a~~ '''[[~~pheochromocytoma~~]]''' with ~~coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells~~.		File:Histopathology of pheochromocytoma.jpg\|thumb\|250px\|'''[[Pheochromocytoma]]''', with typical features shown.
	</gallery>		</gallery>

Mikael Häggström: /* Other adrenal tumors */ Linked

2022-03-01T21:40:53Z

Other adrenal tumors: Linked

← Older revision		Revision as of 17:40, 1 March 2022
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	===Other adrenal tumors===		===Other adrenal tumors===
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|Histopathology of a '''pheochromocytoma''' with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right).		File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|Histopathology of a '''[[pheochromocytoma]]''' with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells.
	</gallery>		</gallery>

Mikael Häggström: +Reporting

2021-09-09T13:12:14Z

+Reporting

← Older revision		Revision as of 09:12, 9 September 2021
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	File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|Histopathology of a '''pheochromocytoma''' with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right).		File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|Histopathology of a '''pheochromocytoma''' with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right).
	</gallery>		</gallery>

			==Reporting==
			{{CAP}}
	{{Bottom}}		{{Bottom}}

Mikael Häggström: Started

2020-07-02T17:06:22Z

Started

New page

{{Top
|author1=[[User:Mikael Häggström|Mikael Häggström]]
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[[File:Incidences and prognoses of adrenal tumors.png|thumb|280px|Incidences and prognoses of adrenal tumors.<ref>Data and references for pie chart are located at [https://commons.wikimedia.org/wiki/File:Incidences_and_prognoses_of_adrenal_tumors.png file description page in Wikimedia Commons.]</ref>]]

===Adenoma versus carcinoma===
The most common adrenal tumors are adrenocortical adenomas and carcinomas. These are most commonly distinguished by the Weiss system,<ref name="WangSun2014">{{cite journal|last1=Wang|first1=Cuiping|last2=Sun|first2=Yang|last3=Wu|first3=Huanwen|last4=Zhao|first4=Dachun|last5=Chen|first5=Jie|title=Distinguishing adrenal cortical carcinomas and adenomas: a study of clinicopathological features and biomarkers|journal=Histopathology|volume=64|issue=4|year=2014|pages=567–576|issn=03090167|doi=10.1111/his.12283}}</ref> as follows:<ref name="AyeMyint2015">{{cite journal|last1=Aye|first1=Than Than|last2=Myint|first2=Phone|last3=Myint|first3=Kyar Nyo Soe|title=Adrenocortical Oncocytoma Presenting with Gynaecomastia|journal=Journal of the ASEAN Federation of Endocrine Societies|volume=30|issue=1|year=2015|pages=27–30|issn=08571074|doi=10.15605/jafes.030.01.08}}</ref>
{|class="wikitable"
! Characteristic<ref name="AyeMyint2015">{{cite journal|last1=Aye|first1=Than Than|last2=Myint|first2=Phone|last3=Myint|first3=Kyar Nyo Soe|title=Adrenocortical Oncocytoma Presenting with Gynaecomastia|journal=Journal of the ASEAN Federation of Endocrine Societies|volume=30|issue=1|year=2015|pages=27–30|issn=08571074|doi=10.15605/jafes.030.01.08}}</ref> !! Score
|-
| High nuclear grade (enlarged, oval to lobated, with coarsely granular to hyperchromatic chromatin and easily discernible, prominent nucleoli)<ref>{{cite web|url=https://oncohemakey.com/adrenocortical-cancer/|title=Adrenocortical Cancer|author=Tito Fojo|accessdate=2020-07-02}}</ref> || 1
|-
| More mitoses than 5/50 high power fields || 1
|-
| Atypical mitoses || 1
|-
| Eosinophilic cytoplasm in >75% of tumor cells || 1
|-
| Diffuse architecture of >33% of tumor || 1
|-
| Necrosis || 1
|-
| Venous invasion || 1
|-
| Sinusoidal invasion (no smooth muscle in wall) || 1
|-
| Capsular invasion || 1
|}
Total score indicates:<ref name="AyeMyint2015"/>
*0-2: Adrenocortical adenoma
*3: Undetermined
*4-9: Adrenocortical carcinoma

<gallery mode=packed heights=200>
File:Adrenal gland Conn syndrome4.jpg|Gross pathology of '''adrenocortical adenoma'''.
File:Histopathology of adrenocortical adenoma.jpg|Histopathology of '''adrenocortical adenoma''', most commonly showing clear cells with high lipid contents.<ref>{{cite journal|last1=Mete|first1=Ozgur|last2=Duan|first2=Kai|title=The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity|journal=Frontiers in Medicine|volume=5|year=2018|issn=2296-858X|doi=10.3389/fmed.2018.00054}}<br>Attribution 4.0 International (CC BY 4.0) license</ref>
File:Adrenal cortical carcinoma.JPG|Gross pathology of '''adrenocortical carcinoma'''. They are generally large, with a tan-yellow cut surface, and often have areas of hemorrhage and necrosis.
File:Histopathology of adrenocortical carcinoma.jpg|Histopathology of '''adrenocortical carcinoma''', with marked mitotic activity.
</gallery>

===Other adrenal tumors===
<gallery mode=packed heights=220>
File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg|Histopathology of a '''pheochromocytoma''' with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right).
</gallery>
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