Ductal carcinoma in situ - Revision history

Mikael Häggström: Templated

2025-06-02T18:34:45Z

Templated

← Older revision		Revision as of 14:34, 2 June 2025
Line 19:		Line 19:
	File:Histopathology of microinvasive ductal carcinoma in situ.png\|'''DCIS with microinvasion''', defined as DCIS with focus of invasive cancer measuring up to 1.0 mm in size.<ref>Image annotation by Mikael Häggström, MD, using source image from:<br>{{cite journal\| author=Moatasim A, Mamoon N\| title=Primary Breast Mucinous Cystadenocarcinoma and Review of Literature. \| journal=Cureus \| year= 2022 \| volume= 14 \| issue= 3 \| pages= e23098 \| pmid=35464581 \| doi=10.7759/cureus.23098 \| pmc=8997314 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35464581 }}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0."<br>'''Source for microinvasion''': {{cite web\|url=https://documents.cap.org/protocols/Breast.DCIS_4.4.0.0.REL_CAPCP.pdf\|title=Protocol for the Examination of Resection Specimens from Patients with Ductal Carcinoma In Situ (DCIS) of the Breast, Version: 4.4.0.0. Protocol Posting Date: June 2021\|website=College of American Pathologists}}</ref>		File:Histopathology of microinvasive ductal carcinoma in situ.png\|'''DCIS with microinvasion''', defined as DCIS with focus of invasive cancer measuring up to 1.0 mm in size.<ref>Image annotation by Mikael Häggström, MD, using source image from:<br>{{cite journal\| author=Moatasim A, Mamoon N\| title=Primary Breast Mucinous Cystadenocarcinoma and Review of Literature. \| journal=Cureus \| year= 2022 \| volume= 14 \| issue= 3 \| pages= e23098 \| pmid=35464581 \| doi=10.7759/cureus.23098 \| pmc=8997314 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35464581 }}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0."<br>'''Source for microinvasion''': {{cite web\|url=https://documents.cap.org/protocols/Breast.DCIS_4.4.0.0.REL_CAPCP.pdf\|title=Protocol for the Examination of Resection Specimens from Patients with Ductal Carcinoma In Situ (DCIS) of the Breast, Version: 4.4.0.0. Protocol Posting Date: June 2021\|website=College of American Pathologists}}</ref>
	</gallery>		</gallery>
	In uncertain cases, use immunohistochemistry stain for ~~'''calponin''' (has the highest sensitivity) and '''p63''' (has the highest specificity)~~.		In uncertain cases, use immunohistochemistry stain for myoepithelial markers{{Myoepithelial marker note}}.
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Immunohistochemistry with calponin in ductal carcinoma in situ.jpg\|Immunohistochemistry for the myoepithelial marker{{Myoepithelial marker note}} calponin in '''ductal carcinoma in situ''', highlighting myoepithelial cells around all tumor cells, thereby ruling out [[invasive ductal carcinoma]].		File:Immunohistochemistry with calponin in ductal carcinoma in situ.jpg\|Immunohistochemistry for the myoepithelial marker{{Myoepithelial marker note}} calponin in '''ductal carcinoma in situ''', highlighting myoepithelial cells around all tumor cells, thereby ruling out [[invasive ductal carcinoma]].

Mikael Häggström: /* Extent */ +Microcalcs

2023-12-08T19:26:11Z

Extent: +Microcalcs

← Older revision		Revision as of 15:26, 8 December 2023
Line 92:		Line 92:
	*In '''biopsies''', do not state the extent of DCIS.		*In '''biopsies''', do not state the extent of DCIS.
	*In '''excisions''', state the distance to the closest margin. {{Moderate-begin}}Additional extent specification is optional. If there is invasive tumor in addition to DCIS, you may give the DCIS extent in terms of the number of blocks containing DCIS. If an excision has DCIS without any invasive component, consider stating the total size in terms of the greatest distance between any DCIS foci.{{Moderate-end}}		*In '''excisions''', state the distance to the closest margin. {{Moderate-begin}}Additional extent specification is optional. If there is invasive tumor in addition to DCIS, you may give the DCIS extent in terms of the number of blocks containing DCIS. If an excision has DCIS without any invasive component, consider stating the total size in terms of the greatest distance between any DCIS foci.{{Moderate-end}}
			[[File:Histopathology of dystrophic microcalcifications in ductal carcinoma in situ.jpg\|thumb\|170px\|Histopathology of dystrophic microcalcifications in DCIS.]]
			{{Microcalcifications in breast cancer}}

	===Estrogen and progesterone receptors===		===Estrogen and progesterone receptors===

Mikael Häggström: /* Reporting */ +Patterns

2023-10-29T18:46:01Z

Reporting: +Patterns

← Older revision		Revision as of 14:46, 29 October 2023
Line 101:		Line 101:

	==Reporting==		==Reporting==
			[[File:Histopathologic architectural patterns of DCIS.png\|thumb\|Architectural patterns of DCIS.<ref>Top and bottom left images by Mikael Häggström, MD. Bottom right image from:<br>{{cite journal\| author=Kulka J, Madaras L, Floris G, Lax SF\| title=Papillary lesions of the breast. \| journal=Virchows Arch \| year= 2022 \| volume= 480 \| issue= 1 \| pages= 65-84 \| pmid=34734332 \| doi=10.1007/s00428-021-03182-7 \| pmc=8983543 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34734332 }}<br> - "This article is licensed under a Creative Commons Attribution 4.0 International License"</ref>]]
	Example:		Example:
	{\|class=wikitable		{\|class=wikitable

Mikael Häggström: /* Grading */ br

2023-10-29T17:39:17Z

Grading: br

← Older revision		Revision as of 13:39, 29 October 2023
Line 56:		Line 56:
	[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]		[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]
	*Substantial tumor cell (comedo) necrosis is present		*Substantial tumor cell (comedo) necrosis is present
	[[File:Histopathology of high-grade DCIS.png\|thumb\|\|220px\|High-grade DCIS. H&E stain. RBC = red blood cell.<ref>Image by Mikael Häggström, MD. References for features:<br>- {{cite web\|url=http://surgpathcriteria.stanford.edu/breast/dcis/grading.html\|title=Ductal Carcinoma in Situ of the Breast\|website=Stanford Medical School\|date=2020-08-27}}<br>- {{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }}</ref>]]		[[File:Histopathology of high-grade DCIS.png\|thumb\|\|220px\|High-grade DCIS. H&E stain.<br>RBC = red blood cell.<ref>Image by Mikael Häggström, MD. References for features:<br>- {{cite web\|url=http://surgpathcriteria.stanford.edu/breast/dcis/grading.html\|title=Ductal Carcinoma in Situ of the Breast\|website=Stanford Medical School\|date=2020-08-27}}<br>- {{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }}</ref>]]
	;High grade DCIS		;High grade DCIS
	*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)		*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)

Mikael Häggström: /* Grading */ ]]

2023-10-29T17:38:29Z

Grading: ]]

← Older revision		Revision as of 13:38, 29 October 2023
Line 56:		Line 56:
	[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]		[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]
	*Substantial tumor cell (comedo) necrosis is present		*Substantial tumor cell (comedo) necrosis is present
	[[File:Histopathology of high-grade DCIS.png\|thumb\|\|220px\|High-grade DCIS. H&E stain. RBC = red blood cell.<ref>Image by Mikael Häggström, MD. References for features:<br>- {{cite web\|url=http://surgpathcriteria.stanford.edu/breast/dcis/grading.html\|title=Ductal Carcinoma in Situ of the Breast\|website=Stanford Medical School\|date=2020-08-27}}<br>- {{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }}</ref>		[[File:Histopathology of high-grade DCIS.png\|thumb\|\|220px\|High-grade DCIS. H&E stain. RBC = red blood cell.<ref>Image by Mikael Häggström, MD. References for features:<br>- {{cite web\|url=http://surgpathcriteria.stanford.edu/breast/dcis/grading.html\|title=Ductal Carcinoma in Situ of the Breast\|website=Stanford Medical School\|date=2020-08-27}}<br>- {{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }}</ref>]]
	;High grade DCIS		;High grade DCIS
	*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)		*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)

Mikael Häggström: /* Grading */ +High-grade

2023-10-29T17:37:49Z

Grading: +High-grade

← Older revision		Revision as of 13:37, 29 October 2023
Line 56:		Line 56:
	[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]		[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]
	*Substantial tumor cell (comedo) necrosis is present		*Substantial tumor cell (comedo) necrosis is present
			[[File:Histopathology of high-grade DCIS.png\|thumb\|\|220px\|High-grade DCIS. H&E stain. RBC = red blood cell.<ref>Image by Mikael Häggström, MD. References for features:<br>- {{cite web\|url=http://surgpathcriteria.stanford.edu/breast/dcis/grading.html\|title=Ductal Carcinoma in Situ of the Breast\|website=Stanford Medical School\|date=2020-08-27}}<br>- {{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }}</ref>
	;High grade DCIS		;High grade DCIS
	*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)		*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)

Mikael Häggström: /* Grading */ Corrected

2023-10-29T17:20:47Z

Grading: Corrected

← Older revision		Revision as of 13:20, 29 October 2023
Line 57:		Line 57:
	*Substantial tumor cell (comedo) necrosis is present		*Substantial tumor cell (comedo) necrosis is present
	;High grade DCIS		;High grade DCIS
	*Nuclei >15 microns (over 3 times the size of a red blood cell)		*Nuclei >15 microns (over 2.5<ref name=Hayward2020>{{cite journal\| author=Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC \| display-authors=etal\| title=Derivation of a nuclear heterogeneity image index to grade DCIS. \| journal=Comput Struct Biotechnol J \| year= 2020 \| volume= 18 \| issue= \| pages= 4063-4070 \| pmid=33363702 \| doi=10.1016/j.csbj.2020.11.040 \| pmc=7744935 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33363702 }} </ref> times the size of a red blood cell)
	*Nuclei are pleomorphic with clumped chromatin		*Nuclei are pleomorphic with clumped chromatin
	*Nucleoli are prominent, enlarged		*Nucleoli are prominent, enlarged

Mikael Häggström: /* Grading */ Bolded

2023-10-29T17:02:31Z

Grading: Bolded

← Older revision		Revision as of 13:02, 29 October 2023
Line 54:		Line 54:
	;Intermediate grade DCIS		;Intermediate grade DCIS
	*Same nuclear features as low grade		*Same nuclear features as low grade
	[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with comedo necrosis spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]		[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with '''comedo necrosis''' spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]
	*Substantial tumor cell (comedo) necrosis is present		*Substantial tumor cell (comedo) necrosis is present
	;High grade DCIS		;High grade DCIS

Mikael Häggström: /* Grading */ +Comedo

2023-10-29T16:59:23Z

Grading: +Comedo

← Older revision		Revision as of 12:59, 29 October 2023
Line 54:		Line 54:
	;Intermediate grade DCIS		;Intermediate grade DCIS
	*Same nuclear features as low grade		*Same nuclear features as low grade
			[[File:Histopathology of ductal carcinoma in situ with comedo necrosis.jpg\|thumb\|220px\|Ductal carcinoma in situ with comedo necrosis spanning 30% of its diameter, which is generally regarded as the minimal size to classify it as comedo.<ref name="pmid30980039">Image by Mikael Häggström, MD.<br>- Reference for most common definition of comedo necrosis by size:<br>- {{cite journal\| author=Harrison BT, Hwang ES, Partridge AH, Thompson AM, Schnitt SJ\| title=Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. \| journal=Mod Pathol \| year= 2019 \| volume= 32 \| issue= 9 \| pages= 1257-1262 \| pmid=30980039 \| doi=10.1038/s41379-019-0262-4 \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30980039 }}</ref>]]
	*Substantial tumor cell (comedo) necrosis is present		*Substantial tumor cell (comedo) necrosis is present
	;High grade DCIS		;High grade DCIS

Mikael Häggström:

2023-10-20T17:12:14Z

← Older revision		Revision as of 13:12, 20 October 2023
Line 1:		Line 1:
	{{Top		<noinclude>{{Top
	\|author1=[[User:Mikael Häggström\|Mikael Häggström]]		\|author1=[[User:Mikael Häggström\|Mikael Häggström]]
	\|author2=		\|author2=
	}}		}}
	Ductal carcinoma in situ (DCIS):		Ductal carcinoma in situ (DCIS):
	{{Comprehensiveness}}		{{Comprehensiveness}}</noinclude>
	==Gross examination==		==Gross examination==
	As per:		As per:
Line 105:		Line 105:
	{{CAP}}		{{CAP}}
	{{Reporting}}		{{Reporting}}
	{{Bottom}}		<noinclude>{{Bottom}}
			</noinclude>