Endometrial polyp - Revision history

Mikael Häggström: /* Microscopic evaluation */ corrected

2026-07-16T02:00:40Z

Microscopic evaluation: corrected

← Older revision		Revision as of 22:00, 15 July 2026
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	*Look for signs of '''atypia or malignancy'''.		*Look for signs of '''atypia or malignancy'''.
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Endometrial polyp''' (without atypia), with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are ~~regular~~.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Endometrial polyp''' (without atypia), with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are may be cystic but have unremarkable linings.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}

Mikael Häggström: /* Microscopic evaluation */ EIN

2022-08-09T02:51:35Z

Microscopic evaluation: EIN

← Older revision		Revision as of 22:51, 8 August 2022
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	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of endometrial intraepithelial neoplasia (EIN).jpg\|'''Atypia''' (mainly seen as signs of '''endometrial intraepithelial neoplasia''' ('''EIN'''), which has the following criteria:<ref name="OwingsQuick2014">{{cite journal\|last1=Owings\|first1=Richard A.\|last2=Quick\|first2=Charles M.\|title=Endometrial Intraepithelial Neoplasia\|journal=Archives of Pathology & Laboratory Medicine\|volume=138\|issue=4\|year=2014\|pages=484–491\|issn=1543-2165\|doi=10.5858/arpa.2012-0709-RA}}</ref><br>- Architectural gland crowding<br>- Altered cytology relative to background glands<br>- Minimum size of 1 mm<br>- Exclusion of adenocarcinoma<br>- Exclusion of mimics<br>Mitoses should also preferably be seen.
			File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref> arising in an endometrial polyp. These are most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}
	</gallery>		</gallery>

Mikael Häggström: /* Microscopic evaluation */ Old terminology

2022-08-09T02:46:11Z

Microscopic evaluation: Old terminology

← Older revision		Revision as of 22:46, 8 August 2022
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	*Look for signs of '''atypia or malignancy'''.		*Look for signs of '''atypia or malignancy'''.
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''~~Non-complex endometrial~~ polyp ~~without atypia~~''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Endometrial polyp''' (without atypia), with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''~~Non-complex endometrial~~ polyp ~~without atypia~~''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}

Mikael Häggström: /* Microscopic evaluation */ Better image

2022-05-24T23:31:04Z

Microscopic evaluation: Better image

← Older revision		Revision as of 19:31, 24 May 2022
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	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of ~~low-grade (FIGO grade 1)~~ endometrial ~~endometrioid adenocarcinoma~~.~~png~~\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}
	</gallery>		</gallery>

Mikael Häggström: /* Microscopic evaluation */ not always

2022-05-02T12:18:51Z

Microscopic evaluation: not always

← Older revision		Revision as of 08:18, 2 May 2022
Line 15:		Line 15:
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>

Mikael Häggström: /* Microscopic evaluation */ +Stroma

2022-05-02T12:16:51Z

Microscopic evaluation: +Stroma

← Older revision		Revision as of 08:16, 2 May 2022
Line 16:		Line 16:
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.
			File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>

Mikael Häggström: /* Microscopic evaluation */ Better

2022-04-29T19:36:10Z

Microscopic evaluation: Better

← Older revision		Revision as of 15:36, 29 April 2022
Line 19:		Line 19:
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of low-grade (FIGO grade 1) endometrial endometrioid adenocarcinoma.png\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of low-grade (FIGO grade 1) endometrial endometrioid adenocarcinoma.png\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of ~~uterine~~ leiomyoma.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a ~~whorled (~~fascicular) pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}
	</gallery>		</gallery>

Mikael Häggström: /* Microscopic evaluation */ described

2022-04-09T14:16:08Z

Microscopic evaluation: described

← Older revision		Revision as of 10:16, 9 April 2022
Line 15:		Line 15:
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>

Mikael Häggström: /* Reporting */ Size

2021-04-06T12:22:16Z

Reporting: Size

← Older revision		Revision as of 08:22, 6 April 2021
Line 25:		Line 25:
	Most importantly:		Most importantly:
	*Benign versus malignant {{Moderate-begin}}or presence or absence of atypia.{{Moderate-end}}		*Benign versus malignant {{Moderate-begin}}or presence or absence of atypia.{{Moderate-end}}
	~~Optionally, report~~ the type of epithelium at both the surface and gland coverings.		*{{Comprehensive-begin}}The size of the polyp.{{Comprehensive-end}}
			*{{Comprehensive-begin}}The type of epithelium at both the surface and gland coverings.{{Comprehensive-end}}

	Example of a minimal report:		Example of a minimal report:
	{\|class=wikitable		{\|class=wikitable
	\| Benign endometrial polyp		\| Benign endometrial polyp.
	\|}		\|}
	{{Reporting}}		{{Reporting}}
	{{Bottom}}		{{Bottom}}

Mikael Häggström: Minimal

2021-04-06T12:20:53Z

Minimal

← Older revision		Revision as of 08:20, 6 April 2021
Line 3:		Line 3:
	\|author2=		\|author2=
	}}		}}
			{{Comprehensiveness}}
	{{Fixation - standard}}		{{Fixation - standard}}
	{{Fixation - general notes}}		{{Fixation - general notes}}
Line 23:		Line 24:
	==Reporting==		==Reporting==
	Most importantly:		Most importantly:
	*~~Presence~~ or absence of atypia.		*Benign versus malignant {{Moderate-begin}}or presence or absence of atypia.{{Moderate-end}}
	Optionally, report the type of epithelium at both the surface and gland coverings.		Optionally, report the type of epithelium at both the surface and gland coverings.

			Example of a minimal report:
			{\|class=wikitable
			\| Benign endometrial polyp
			\|}
	{{Reporting}}		{{Reporting}}
	{{Bottom}}		{{Bottom}}

← Older revision		Revision as of 22:51, 8 August 2022
Line 17:		Line 17:
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of endometrial intraepithelial neoplasia (EIN).jpg\|'''Atypia''' (mainly seen as signs of '''endometrial intraepithelial neoplasia''' ('''EIN'''), which has the following criteria:<ref name="OwingsQuick2014">{{cite journal\|last1=Owings\|first1=Richard A.\|last2=Quick\|first2=Charles M.\|title=Endometrial Intraepithelial Neoplasia\|journal=Archives of Pathology & Laboratory Medicine\|volume=138\|issue=4\|year=2014\|pages=484–491\|issn=1543-2165\|doi=10.5858/arpa.2012-0709-RA}}</ref><br>- Architectural gland crowding<br>- Altered cytology relative to background glands<br>- Minimum size of 1 mm<br>- Exclusion of adenocarcinoma<br>- Exclusion of mimics<br>Mitoses should also preferably be seen.
			File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref> arising in an endometrial polyp. These are most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}
	</gallery>		</gallery>

← Older revision		Revision as of 22:46, 8 August 2022
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	*Look for signs of '''atypia or malignancy'''.		*Look for signs of '''atypia or malignancy'''.
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''~~Non-complex endometrial~~ polyp ~~without atypia~~''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Endometrial polyp''' (without atypia), with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''~~Non-complex endometrial~~ polyp ~~without atypia~~''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Endometrial polyp''' (without atypia), with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}

← Older revision		Revision as of 19:31, 24 May 2022
Line 19:		Line 19:
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of ~~low-grade (FIGO grade 1)~~ endometrial ~~endometrioid adenocarcinoma~~.~~png~~\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>		File:Histopathology of Serous carcinoma arising in endometrial polyp.jpg\|'''[[Endometrial adenocarcinoma]]'''<ref>{{cite journal\|last1=Stewart\|first1=Colin J.R.\|last2=Crum\|first2=Christopher P.\|last3=McCluggage\|first3=W. Glenn\|last4=Park\|first4=Kay J.\|last5=Rutgers\|first5=Joanne K.\|last6=Oliva\|first6=Esther\|last7=Malpica\|first7=Anais\|last8=Parkash\|first8=Vinita\|last9=Matias-Guiu\|first9=Xavier\|last10=Ronnett\|first10=Brigitte M.\|title=Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S75–S92\|issn=0277-1691\|doi=10.1097/PGP.0000000000000553}}<br>- "Figures - available via license: Creative Commons Attribution 4.0 International"</ref>, most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.<ref name="RabbanGilks2019">{{cite journal\|last1=Rabban\|first1=Joseph T.\|last2=Gilks\|first2=C. Blake\|last3=Malpica\|first3=Anais\|last4=Matias-Guiu\|first4=Xavier\|last5=Mittal\|first5=Khush\|last6=Mutter\|first6=George L.\|last7=Oliva\|first7=Esther\|last8=Parkash\|first8=Vinita\|last9=Ronnett\|first9=Brigitte M.\|last10=Staats\|first10=Paul\|last11=Stewart\|first11=Colin J.R.\|last12=McCluggage\|first12=W. Glenn\|title=Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas\|journal=International Journal of Gynecological Pathology\|volume=38\|year=2019\|pages=S25–S39\|issn=0277-1691\|doi=10.1097/PGP.0000000000000512}}</ref>
	File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}		File:Histopathology of a leiomyoma with fascicular growth.jpg\|Subserosal pedunculated uterine '''leiomyomas''' may present as endometrial polyps. They typically show smooth muscle in a fascicular pattern<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/uterusleiomyoma.html\|title=Uterus - Stromal tumors - Leiomyoma\|author=Mohamed Mokhtar Desouki\|website=pathology Outlines}} Topic Completed: 1 August 2011. Revised: 15 December 2019</ref> {{further\|Smooth muscle tumor\|linebreak=no}}
	</gallery>		</gallery>

← Older revision		Revision as of 08:18, 2 May 2022
Line 15:		Line 15:
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic in this case.
	File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}		File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>

← Older revision		Revision as of 08:16, 2 May 2022
Line 16:		Line 16:
	File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.		File:Histopathology of non-complex endometrial polyp without atypia.jpg\|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
	File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.		File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg\|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow, showing ciliated epithelium) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.
			File:Myometrium versus endometrial stroma versus endometrial polyp stroma.jpg\|Myometrium (smooth muscle cells) versus endometrial stroma (more cellular) versus '''endometrial polyp stroma''' (more collagenous).{{MH}}
	File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia without atypia.jpg\|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
	File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>		File:Histopathology of complex hyperplasia with atypia.jpg\|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal\|last1=Rao\|first1=Shalinee\|last2=Sundaram\|first2=Sandhya\|last3=Narasimhan\|first3=Raghavan\|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India\|journal=Indian Journal of Medical and Paediatric Oncology\|volume=30\|issue=4\|year=2009\|pages=131\|issn=0971-5851\|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>