Follicular hyperplasia - Revision history

Mikael Häggström: Linked

2021-11-10T21:49:01Z

Linked

← Older revision		Revision as of 17:49, 10 November 2021
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	Main differences:<ref name="WeissO'Malley2013"/>		Main differences:<ref name="WeissO'Malley2013"/>
	{\|class=wikitable		{\|class=wikitable
	! Feature !! Follicular hyperplasia of a '''[[reactive lymph node]]''' !! Follicular lymphoma		! Feature !! Follicular hyperplasia of a '''[[reactive lymph node]]''' !! '''[[Follicular lymphoma]]'''
	\|-		\|-
	! Density of follicles		! Density of follicles

Mikael Häggström: Linked

2021-07-03T18:32:21Z

Linked

← Older revision		Revision as of 14:32, 3 July 2021
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	'''Follicular hyperplasia''' is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> Reactive follicular hyperplasia is usually associated with varying degrees of paracortical and/or sinus hyperplasia. Older age, increased follicular density (especially back-to-back arrangement) and areas of diffuse nodal effacement leads to a suspicion of '''[[follicular lymphoma]]'''.<ref name="WeissO'Malley2013"/>		'''Follicular hyperplasia''' is the most common pattern of '''[[reactive lymphadenopathy]]'''.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> Reactive follicular hyperplasia is usually associated with varying degrees of paracortical and/or sinus hyperplasia. Older age, increased follicular density (especially back-to-back arrangement) and areas of diffuse nodal effacement leads to a suspicion of '''[[follicular lymphoma]]'''.<ref name="WeissO'Malley2013"/>
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia		File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia
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	Main differences:<ref name="WeissO'Malley2013"/>		Main differences:<ref name="WeissO'Malley2013"/>
	{\|class=wikitable		{\|class=wikitable
	! Feature !! ~~Reactive follicular~~ hyperplasia !! Follicular lymphoma		! Feature !! Follicular hyperplasia of a '''[[reactive lymph node]]''' !! Follicular lymphoma
	\|-		\|-
	! Density of follicles		! Density of follicles
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	If uncertain, perform the following studies:<ref name="WeissO'Malley2013"/>		If uncertain, perform the following studies:<ref name="WeissO'Malley2013"/>
	{\|class=wikitable		{\|class=wikitable
	! Feature !! Reactive ~~follicular hyperplasia~~ !! Follicular lymphoma		! Feature !! '''[[Reactive lymph node]]''' !! Follicular lymphoma
	\|-		\|-
	! Bcl-2 in B cells of germinal centers		! Bcl-2 in B cells of germinal centers

Mikael Häggström: Wording

2020-08-17T15:55:38Z

Wording

← Older revision		Revision as of 11:55, 17 August 2020
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	Follicular hyperplasia is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> It is usually associated with varying degrees of paracortical and/or sinus hyperplasia. Older age, increased follicular density (especially back-to-back arrangement) and areas of diffuse nodal effacement leads to a suspicion of '''[[follicular lymphoma]]'''.<ref name="WeissO'Malley2013"/>		'''Follicular hyperplasia''' is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> Reactive follicular hyperplasia is usually associated with varying degrees of paracortical and/or sinus hyperplasia. Older age, increased follicular density (especially back-to-back arrangement) and areas of diffuse nodal effacement leads to a suspicion of '''[[follicular lymphoma]]'''.<ref name="WeissO'Malley2013"/>
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia		File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia

Mikael Häggström: Mikael Häggström moved page Follicular lymphoma versus reactive follicular hyperplasia to Follicular hyperplasia: To finding

2020-08-17T15:54:58Z

Mikael Häggström moved page Follicular lymphoma versus reactive follicular hyperplasia to Follicular hyperplasia: To finding

← Older revision	Revision as of 11:54, 17 August 2020
(No difference)

Mikael Häggström: +Clinical

2020-08-17T15:54:11Z

+Clinical

← Older revision		Revision as of 11:54, 17 August 2020
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	Follicular hyperplasia is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> It is usually associated with varying degrees of paracortical and/or sinus hyperplasia.		Follicular hyperplasia is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> It is usually associated with varying degrees of paracortical and/or sinus hyperplasia. Older age, increased follicular density (especially back-to-back arrangement) and areas of diffuse nodal effacement leads to a suspicion of '''[[follicular lymphoma]]'''.<ref name="WeissO'Malley2013"/>
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia		File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia

Mikael Häggström: ]]

2020-08-13T22:44:41Z

]]

← Older revision		Revision as of 18:44, 13 August 2020
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	Follicular hyperplasia is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> It is usually associated with varying degrees of paracortical and/or sinus hyperplasia.		Follicular hyperplasia is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal\|last1=Weiss\|first1=Lawrence M\|last2=O'Malley\|first2=Dennis\|title=Benign lymphadenopathies\|journal=Modern Pathology\|volume=26\|issue=S1\|year=2013\|pages=S88–S96\|issn=0893-3952\|doi=10.1038/modpathol.2012.176}}</ref> It is usually associated with varying degrees of paracortical and/or sinus hyperplasia.
	<gallery mode=packed heights=220>		<gallery mode=packed heights=220>
	File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia]]		File:Histopathology of reactive follicular hyperplasia.jpg\|thumb\|Histopathology of reactive follicular hyperplasia
	</gallery>		</gallery>

Mikael Häggström: Started

2020-08-13T22:44:23Z

Started

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|author1=[[User:Mikael Häggström|Mikael Häggström]]
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Follicular hyperplasia is the most common pattern of reactive lymphadenopathy.<ref name="WeissO'Malley2013">{{cite journal|last1=Weiss|first1=Lawrence M|last2=O'Malley|first2=Dennis|title=Benign lymphadenopathies|journal=Modern Pathology|volume=26|issue=S1|year=2013|pages=S88–S96|issn=0893-3952|doi=10.1038/modpathol.2012.176}}</ref> It is usually associated with varying degrees of paracortical and/or sinus hyperplasia.
<gallery mode=packed heights=220>
File:Histopathology of reactive follicular hyperplasia.jpg|thumb|Histopathology of reactive follicular hyperplasia]]
</gallery>

Main differences:<ref name="WeissO'Malley2013"/>
{|class=wikitable
! Feature !! Reactive follicular hyperplasia !! Follicular lymphoma
|-
! Density of follicles
| Low || High
|-
! Follicle distribution
| Usually limited to subcortical region || Distributed evenly throughout parenchyma
|-
! Follicles extending beyond capsule
| Rarely || Often
|-
! Follicle sizes and shapes
| Uneven || Similar
|-
! Cell types in germinal centers
| Mixture of cells || Monomorphic or polymorphic
|-
! Tingible-body macrophages
| Present || Usually rare
|-
! Mitotic rate
| Usually moderate to high || Usually low to moderate
|-
! Mantle zone
| Usually distinct || Usually indistinct or absent
|-
! Cell polarization
| Often seen || Usually absent
|-
! Interfollicular areas
| Large || Compressed
|-
! Areas of nodal effacement
| Absent || Occasional
|}

If uncertain, perform the following studies:<ref name="WeissO'Malley2013"/>
{|class=wikitable
! Feature !! Reactive follicular hyperplasia !! Follicular lymphoma
|-
! Bcl-2 in B cells of germinal centers
| Negative || Positive (90%)
|-
! Light chain restriction on immunostains
| Absent (rare exceptions) || Present (20% in paraffin)
|-
! Light chain restriction on flow cytometry
| Absent restriction (rare exceptions) || Restriction or absent, when gated correctly (95%)
|-
! Ig rearrangements
| Absent (rare exceptions) || Usually (80%)
|-
! t(14;18)
| Absent (rare exceptions) || Usually present (90%)
|}
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