Gastroesophageal junction - Revision history

Mikael Häggström: -type

2026-07-28T16:28:08Z

-type

← Older revision		Revision as of 12:28, 28 July 2026
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	Examples:		Examples:
	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Squamous mucosa without significant histopathologic changes.<br>{{Moderate-begin}}Negative for gastric mucosa or intestinalized (Barrett's) mucosa.{{Moderate-end}}<br>{{Comprehensive-begin}}Negative for dysplasia and malignancy.{{Comprehensive-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Squamous mucosa without significant histopathologic changes.<br>{{Moderate-begin}}Negative for gastric mucosa or intestinalized (Barrett-type) mucosa.{{Moderate-end}}<br>{{Comprehensive-begin}}Negative for dysplasia and malignancy.{{Comprehensive-end}}
	\|}		\|}

	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with '''chronic inflammation''' and reactive changes{{Moderate-begin}}, non-specific.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}{{Comprehensive-begin}}, dysplasia, and malignancy{{Comprehensive-end}}.		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with '''chronic inflammation''' and reactive changes{{Moderate-begin}}, non-specific.<br>Negative for intestinalized (Barrett-type) mucosa.{{Moderate-end}}{{Comprehensive-begin}}, dysplasia, and malignancy{{Comprehensive-end}}.
	\|}		\|}

	In case of multiple signs of reflux esophagitis:		In case of multiple signs of reflux esophagitis:
	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett's) mucosa{{Moderate-end}}{{Comprehensive-begin}}, dysplasia, and malignancy{{Comprehensive-end}}.		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett-type) mucosa{{Moderate-end}}{{Comprehensive-begin}}, dysplasia, and malignancy{{Comprehensive-end}}.
	\|}		\|}
	<noinclude>{{Bottom}}</noinclude>		<noinclude>{{Bottom}}</noinclude>

Mikael Häggström: dysplasia

2026-07-16T18:33:10Z

dysplasia

← Older revision		Revision as of 14:33, 16 July 2026
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	Examples:		Examples:
	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Squamous mucosa without significant histopathologic changes.<br>{{Moderate-begin}}Negative for gastric mucosa or intestinalized (Barrett's) mucosa.{{Moderate-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Squamous mucosa without significant histopathologic changes.<br>{{Moderate-begin}}Negative for gastric mucosa or intestinalized (Barrett's) mucosa.{{Moderate-end}}<br>{{Comprehensive-begin}}Negative for dysplasia and malignancy.{{Comprehensive-end}}
	\|}		\|}

	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with '''chronic inflammation''' and reactive changes{{Moderate-begin}}, non-specific.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with '''chronic inflammation''' and reactive changes{{Moderate-begin}}, non-specific.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}{{Comprehensive-begin}}, dysplasia, and malignancy{{Comprehensive-end}}.
	\|}		\|}

	In case of multiple signs of reflux esophagitis:		In case of multiple signs of reflux esophagitis:
	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett's) mucosa{{Moderate-end}}{{Comprehensive-begin}}, dysplasia, and malignancy{{Comprehensive-end}}.
	\|}		\|}
	<noinclude>{{Bottom}}</noinclude>		<noinclude>{{Bottom}}</noinclude>

Mikael Häggström:

2025-03-20T15:49:13Z

</noinclude>

← Older revision		Revision as of 11:49, 20 March 2025
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	\|author2=		\|author2=
	}}		}}
	{{Endoscopic biopsies}}~~</noinclude>~~		{{Endoscopic biopsies}}
	{{Comprehensiveness}}		{{Comprehensiveness}}</noinclude>
	==Microscopic examination==		==Microscopic examination==
	The main findings to look for are:		The main findings to look for are:

Mikael Häggström: /* Microscopic examination */ Barrett's esophagus

2023-10-06T19:17:04Z

Microscopic examination: Barrett's esophagus

← Older revision		Revision as of 15:17, 6 October 2023
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	==Microscopic examination==		==Microscopic examination==
	The main findings to look for are:		The main findings to look for are:
	*'''[[Intestinalized mucosa]]''' ([[Barrett's esophagus]])		*'''[[Barrett's esophagus\|Intestinalized mucosa]]''' ([[Barrett's esophagus]])
	*(Reflux) '''esophagitis'''.		*(Reflux) '''esophagitis'''.
	*'''Gastritis'''. {{Further\|Stomach\|linebreak=no}}		*'''Gastritis'''. {{Further\|Stomach\|linebreak=no}}

Mikael Häggström:

2022-12-02T23:24:44Z

← Older revision		Revision as of 19:24, 2 December 2022
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	{{Top		<noinclude>{{Top
	\|author1=[[User:Mikael Häggström\|Mikael Häggström]]		\|author1=[[User:Mikael Häggström\|Mikael Häggström]]
	\|author2=		\|author2=
	}}		}}
	~~<noinclude>~~{{Endoscopic biopsies}}</noinclude>		{{Endoscopic biopsies}}</noinclude>
	{{Comprehensiveness}}		{{Comprehensiveness}}
	==Microscopic examination==		==Microscopic examination==
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	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}
	\|}		\|}
	{{Bottom}}		<noinclude>{{Bottom}}</noinclude>

Mikael Häggström: /* Barrett's esophagus */ 220

2022-06-18T21:18:39Z

Barrett's esophagus: 220

← Older revision		Revision as of 17:18, 18 June 2022
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	===Barrett's esophagus===		===Barrett's esophagus===
	The main diagnostic sign of Barrett's esophagus is the presence of '''goblet cells'''. A true goblet cell should have rounded shape, clear to bluish cytoplasmic mucin, and be randomly scattered.<ref name=PathologyOutlines-Barrett>{{cite web\|url=http://www.pathologyoutlines.com/topic/esophagusBarrettsgeneral.html\|title=Esophagus - Premalignant - Barrett esophagus\|author=Dipti M. Karamchandani}} Topic Completed: 19 March 2020, Minor changes: 29 June 2020</ref> The mucin usually indents the nucleus.<ref name=PathologyOutlines-Barrett/>		The main diagnostic sign of Barrett's esophagus is the presence of '''goblet cells'''. A true goblet cell should have rounded shape, clear to bluish cytoplasmic mucin, and be randomly scattered.<ref name=PathologyOutlines-Barrett>{{cite web\|url=http://www.pathologyoutlines.com/topic/esophagusBarrettsgeneral.html\|title=Esophagus - Premalignant - Barrett esophagus\|author=Dipti M. Karamchandani}} Topic Completed: 19 March 2020, Minor changes: 29 June 2020</ref> The mucin usually indents the nucleus.<ref name=PathologyOutlines-Barrett/>
	<gallery mode=packed heights=~~180~~>		<gallery mode=packed heights=220>
	File:Histopathology of Barrett's esophagus, annotated.jpg\|Histopathology of '''[[Barrett's esophagus]]''', showing intestinalized epithelium with goblet cells, as opposed to normal stratified squamous epithelium of the esophagus, and pseudostratified columnar epithelium of the fundus of the stomach. H&E stain.		File:Histopathology of Barrett's esophagus, annotated.jpg\|Histopathology of '''[[Barrett's esophagus]]''', showing intestinalized epithelium with goblet cells, as opposed to normal stratified squamous epithelium of the esophagus, and pseudostratified columnar epithelium of the fundus of the stomach. H&E stain.
	File:Histopathology of goblet cells (annotated) and foveolar cells in incomplete Barrett's esophagus.jpg\|In '''incomplete''' intestinal metaplasia, there are both foveolar cells and goblet cells, the latter (indicated by arrows) usually having a slightly bluish color compared to the apical cytoplasm of foveolar cells. An occasional but specific sign of goblet cells is crescent shaped nuclei (seen in middle one).		File:Histopathology of goblet cells (annotated) and foveolar cells in incomplete Barrett's esophagus.jpg\|In '''incomplete''' intestinal metaplasia, there are both foveolar cells and goblet cells, the latter (indicated by arrows) usually having a slightly bluish color compared to the apical cytoplasm of foveolar cells. An occasional but specific sign of goblet cells is crescent shaped nuclei (seen in middle one).

Mikael Häggström: Noinclude

2022-06-18T21:18:12Z

Noinclude

← Older revision		Revision as of 17:18, 18 June 2022
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	\|author2=		\|author2=
	}}		}}
	{{Endoscopic biopsies}}		<noinclude>{{Endoscopic biopsies}}</noinclude>
	{{Comprehensiveness}}		{{Comprehensiveness}}
	==Microscopic examination==		==Microscopic examination==

Mikael Häggström: /* Report */ begin

2022-04-28T16:19:23Z

Report: begin

← Older revision		Revision as of 12:19, 28 April 2022
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	In case of multiple signs of reflux esophagitis:		In case of multiple signs of reflux esophagitis:
	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>{{Moderate-begin}}Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}
	\|}		\|}
	{{Bottom}}		{{Bottom}}

Mikael Häggström: -Barrett

2022-04-22T18:51:34Z

-Barrett

← Older revision		Revision as of 14:51, 22 April 2022
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	===Barrett's esophagus===		===Barrett's esophagus===
	The main diagnostic sign of Barrett's esophagus is the presence of '''goblet cells'''. A true goblet cell should have rounded shape, clear to bluish cytoplasmic mucin, and be randomly scattered.<ref name=PathologyOutlines>{{cite web\|url=http://www.pathologyoutlines.com/topic/esophagusBarrettsgeneral.html\|title=Esophagus - Premalignant - Barrett esophagus\|author=Dipti M. Karamchandani}} Topic Completed: 19 March 2020, Minor changes: 29 June 2020</ref> The mucin usually indents the nucleus.<ref name=PathologyOutlines/>		The main diagnostic sign of Barrett's esophagus is the presence of '''goblet cells'''. A true goblet cell should have rounded shape, clear to bluish cytoplasmic mucin, and be randomly scattered.<ref name=PathologyOutlines-Barrett>{{cite web\|url=http://www.pathologyoutlines.com/topic/esophagusBarrettsgeneral.html\|title=Esophagus - Premalignant - Barrett esophagus\|author=Dipti M. Karamchandani}} Topic Completed: 19 March 2020, Minor changes: 29 June 2020</ref> The mucin usually indents the nucleus.<ref name=PathologyOutlines-Barrett/>
	<gallery mode=packed heights=180>		<gallery mode=packed heights=180>
	File:Histopathology of Barrett's esophagus, annotated.jpg\|Histopathology of '''[[Barrett's esophagus]]''', showing intestinalized epithelium with goblet cells, as opposed to normal stratified squamous epithelium of the esophagus, and pseudostratified columnar epithelium of the fundus of the stomach. H&E stain.		File:Histopathology of Barrett's esophagus, annotated.jpg\|Histopathology of '''[[Barrett's esophagus]]''', showing intestinalized epithelium with goblet cells, as opposed to normal stratified squamous epithelium of the esophagus, and pseudostratified columnar epithelium of the fundus of the stomach. H&E stain.

Mikael Häggström: /* Report */ Consistent

2022-04-21T16:54:57Z

Report: Consistent

← Older revision		Revision as of 12:54, 21 April 2022
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	{\|class=wikitable		{\|class=wikitable
	\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with '''chronic inflammation''' and reactive changes{{Moderate-begin}}, non-specific.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}		\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with '''chronic inflammation''' and reactive changes{{Moderate-begin}}, non-specific.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}
			\|}

			In case of multiple signs of reflux esophagitis:
			{\|class=wikitable
			\| {{Moderate-begin}}GE junction, biopsy:{{Moderate-end}}<br>Gastroesophageal junctional mucosa with changes consistent with '''reflux esophagitis'''.<br>Negative for intestinalized (Barrett's) mucosa.{{Moderate-end}}
	\|}		\|}
	{{Bottom}}		{{Bottom}}