Hyperthyroidism - Revision history

Mikael Häggström: Fixed

2023-01-09T17:35:59Z

Fixed

← Older revision		Revision as of 13:35, 9 January 2023
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	}}		}}
	[[File:Causes of hyperthyroidism.png\|thumb\|Most common causes of hyperthyroidism by age.<ref>{{cite journal\|last1=Carlé\|first1=Allan\|last2=Pedersen\|first2=Inge Bülow\|last3=Knudsen\|first3=Nils\|last4=Perrild\|first4=Hans\|last5=Ovesen\|first5=Lars\|last6=Rasmussen\|first6=Lone Banke\|last7=Laurberg\|first7=Peter\|title=Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study\|journal=European Journal of Endocrinology\|volume=164\|issue=5\|year=2011\|pages=801–809\|issn=0804-4643\|doi=10.1530/EJE-10-1155\|pmid=21357288}}</ref>		[[File:Causes of hyperthyroidism.png\|thumb\|Most common causes of hyperthyroidism by age.<ref>{{cite journal\|last1=Carlé\|first1=Allan\|last2=Pedersen\|first2=Inge Bülow\|last3=Knudsen\|first3=Nils\|last4=Perrild\|first4=Hans\|last5=Ovesen\|first5=Lars\|last6=Rasmussen\|first6=Lone Banke\|last7=Laurberg\|first7=Peter\|title=Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study\|journal=European Journal of Endocrinology\|volume=164\|issue=5\|year=2011\|pages=801–809\|issn=0804-4643\|doi=10.1530/EJE-10-1155\|pmid=21357288}}</ref>]]
	{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>]]		{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>
	{{Fixation - general notes}}		{{Fixation - general notes}}
	==Gross processing==		==Gross processing==

Mikael Häggström: File

2023-01-09T17:35:28Z

File

← Older revision		Revision as of 13:35, 9 January 2023
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	File:Causes of hyperthyroidism.png\|Most common causes of hyperthyroidism by age.<ref>{{cite journal\|last1=Carlé\|first1=Allan\|last2=Pedersen\|first2=Inge Bülow\|last3=Knudsen\|first3=Nils\|last4=Perrild\|first4=Hans\|last5=Ovesen\|first5=Lars\|last6=Rasmussen\|first6=Lone Banke\|last7=Laurberg\|first7=Peter\|title=Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study\|journal=European Journal of Endocrinology\|volume=164\|issue=5\|year=2011\|pages=801–809\|issn=0804-4643\|doi=10.1530/EJE-10-1155\|pmid=21357288}}</ref>		[[File:Causes of hyperthyroidism.png\|thumb\|Most common causes of hyperthyroidism by age.<ref>{{cite journal\|last1=Carlé\|first1=Allan\|last2=Pedersen\|first2=Inge Bülow\|last3=Knudsen\|first3=Nils\|last4=Perrild\|first4=Hans\|last5=Ovesen\|first5=Lars\|last6=Rasmussen\|first6=Lone Banke\|last7=Laurberg\|first7=Peter\|title=Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study\|journal=European Journal of Endocrinology\|volume=164\|issue=5\|year=2011\|pages=801–809\|issn=0804-4643\|doi=10.1530/EJE-10-1155\|pmid=21357288}}</ref>
	{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>		{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>]]
	{{Fixation - general notes}}		{{Fixation - general notes}}
	==Gross processing==		==Gross processing==

Mikael Häggström: Causes

2023-01-09T17:33:17Z

Causes

← Older revision		Revision as of 13:33, 9 January 2023
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			File:Causes of hyperthyroidism.png\|Most common causes of hyperthyroidism by age.<ref>{{cite journal\|last1=Carlé\|first1=Allan\|last2=Pedersen\|first2=Inge Bülow\|last3=Knudsen\|first3=Nils\|last4=Perrild\|first4=Hans\|last5=Ovesen\|first5=Lars\|last6=Rasmussen\|first6=Lone Banke\|last7=Laurberg\|first7=Peter\|title=Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study\|journal=European Journal of Endocrinology\|volume=164\|issue=5\|year=2011\|pages=801–809\|issn=0804-4643\|doi=10.1530/EJE-10-1155\|pmid=21357288}}</ref>
	{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>		{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>
	{{Fixation - general notes}}		{{Fixation - general notes}}

Mikael Häggström: /* Gross processing */ '

2021-06-14T22:45:03Z

Gross processing: '

← Older revision		Revision as of 18:45, 14 June 2021
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	{{Fixation - general notes}}		{{Fixation - general notes}}
	==Gross processing==		==Gross processing==
	As per standard for ''[[thyroid]]'''.		As per standard for '''[[thyroid]]'''.

	==Microscopic evaluation==		==Microscopic evaluation==

Mikael Häggström: Linked

2021-06-14T22:41:49Z

Linked

← Older revision		Revision as of 18:41, 14 June 2021
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	{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>		{{Fixation - standard}} Fix all thyroids at least overnight to avoid artifactual nuclear atypia.<ref name=chicago2>{{cite web\|url=https://voices.uchicago.edu/grosspathology/head-neck/thyroid/#primary-column\|title=Gross Pathology Manual By The University of Chicago Department of Pathology}} Updated 2-14-19 NAC.</ref>
	{{Fixation - general notes}}		{{Fixation - general notes}}
	{{Gross processing of thyroid}}		==Gross processing==
			As per standard for ''[[thyroid]]'''.

	==Microscopic evaluation==		==Microscopic evaluation==
	The most common cause of hyperthyroidism is Grave's disease (50-80% worldwide). Its typical features are:<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidgraves.html\|title=Thyroid gland - Hyperplasia / goiter - Graves disease\|author=F. Zahra Aly, M.D., Ph.D., Swati Satturwar, M.B.B.S.\|website=PathologyOutlines}} Topic Completed: 1 November 2017, Minor changes: 14 March 2019</ref>		The most common cause of hyperthyroidism is Grave's disease (50-80% worldwide). Its typical features are:<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidgraves.html\|title=Thyroid gland - Hyperplasia / goiter - Graves disease\|author=F. Zahra Aly, M.D., Ph.D., Swati Satturwar, M.B.B.S.\|website=PathologyOutlines}} Topic Completed: 1 November 2017, Minor changes: 14 March 2019</ref>

Mikael Häggström: /* Microscopic evaluation */ Formatting

2020-12-21T19:15:04Z

Microscopic evaluation: Formatting

← Older revision		Revision as of 15:15, 21 December 2020
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	==Microscopic evaluation==		==Microscopic evaluation==
	The most common cause of hyperthyroidism is Grave's disease (50-80% worldwide). Its typical features are:<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidgraves.html\|title=Thyroid gland - Hyperplasia / goiter - Graves disease\|author=F. Zahra Aly, M.D., Ph.D., Swati Satturwar, M.B.B.S.\|website=PathologyOutlines}} Topic Completed: 1 November 2017, Minor changes: 14 March 2019</ref>		The most common cause of hyperthyroidism is Grave's disease (50-80% worldwide). Its typical features are:<ref>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidgraves.html\|title=Thyroid gland - Hyperplasia / goiter - Graves disease\|author=F. Zahra Aly, M.D., Ph.D., Swati Satturwar, M.B.B.S.\|website=PathologyOutlines}} Topic Completed: 1 November 2017, Minor changes: 14 March 2019</ref>
	*Hyperplastic thyroid follicles with papillary infoldings		*'''Hyperplastic''' thyroid follicles with papillary infoldings.
	*Diffuse hyperplasia and hypertrophy of follicular cells with retention of lobular architecture		*Diffuse '''hyperplasia and hypertrophy''' of follicular cells with retention of lobular architecture.
	*Prominent vascular congestion		*Prominent vascular '''congestion'''.
	*Tall follicular cells with papillae that usually lack fibrovascular cores		*'''Tall follicular cells''' with papillae that usually lack fibrovascular cores.
	*Nuclei are round, often basally located, and rarely overlap		*'''Nuclei are round''', often basally located, and rarely overlap.
	*~~Colloid is typically~~ decreased, and when present it typically has peripheral scalloping		*Typically '''decreased colloid''' amount, and when present it typically has peripheral scalloping.
	*Variable patchy lymphoid stromal infiltrate		*Variable patchy lymphoid stromal '''infiltrate'''.

	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>

Mikael Häggström: /* Microscopic evaluation */ format

2020-07-09T22:16:55Z

Microscopic evaluation: format

← Older revision		Revision as of 18:16, 9 July 2020
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	*Variable patchy lymphoid stromal infiltrate		*Variable patchy lymphoid stromal infiltrate

	<gallery mode=packed>		<gallery mode=packed heights=200>
	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><br>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present<ref name=POMultinodular/> (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><br>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

Mikael Häggström: /* Microscopic evaluation */ r

2020-07-09T22:16:06Z

Microscopic evaluation: r

← Older revision		Revision as of 18:16, 9 July 2020
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	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><br>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

Mikael Häggström: /* Microscopic evaluation */ r

2020-07-09T22:15:16Z

Microscopic evaluation: r

← Older revision		Revision as of 18:15, 9 July 2020
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	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<b>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

Mikael Häggström: /* Microscopic evaluation */ Formatting

2020-07-09T22:14:21Z

Microscopic evaluation: Formatting

← Older revision		Revision as of 18:14, 9 July 2020
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	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<b>-Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<b>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

← Older revision		Revision as of 18:16, 9 July 2020
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	*Variable patchy lymphoid stromal infiltrate		*Variable patchy lymphoid stromal infiltrate

	<gallery mode=packed>		<gallery mode=packed heights=200>
	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><br>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present<ref name=POMultinodular/> (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><br>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

← Older revision		Revision as of 18:16, 9 July 2020
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	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><br>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

← Older revision		Revision as of 18:15, 9 July 2020
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	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<b>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<br>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)

← Older revision		Revision as of 18:14, 9 July 2020
Line 19:		Line 19:
	File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.		File:Histopathology of Graves' disease - low mag.jpg\|'''Graves' disease''' - low magnification: exuberant papillary hyperplasia.
	File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.		File:Histopathology of Graves' disease - medium mag.jpg\|'''Graves' disease''' - medium magnification: cells with round nuclei and even chromatin pattern lining the papillae.
	File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<b>-Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/>		File:Histopathology of multinodular toxic goiter.jpg\|'''Toxic multinodular goiter''', whose typical findings are:<br>- Variably dilated follicles with flattened hyperplastic epithelium.<ref name=POMultinodular>{{cite web\|url=http://www.pathologyoutlines.com/topic/thyroidnodular.html\|title=Thyroid gland - Hyperplasia / goiter - Multinodular goiter\|website=PathologyOutlines\|author=Swati Satturwar, M.B.B.S., F. Zahra Aly, M.D., Ph.D.}} Topic Completed: 1 February 2018. Minor changes: 14 December 2019</ref><br>- Nodules may be present (but lack thick capsule in contrast to adenomas).<b>- Potentially focal fresh or old hemorrhages, rupture of follicles with granulomatous inflammation, fibrosis, calcification and even osseous metaplasia.<ref name=POMultinodular/><b>- Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	Also potentially papillary projections (Sanderson polsters) that may mimic papillary carcinoma, but they lack malignant nuclear features.<ref name=POMultinodular/>
	File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes		File:Histopathology of amiodarone associated follicular cell damage - high mag.jpg\|'''Amiodarone associated follicular cell damage''' - high magnification: large thyroid follicles filled with colloid and numerous histiocytes
	File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)		File:Histopathology of amiodarone associated follicular cell damage - low mag.jpg\|'''Amiodarone associated follicular cell damage''' - low magnification: large thyroid follicles filled with colloid and numerous histiocytes (arrow heads)