Kidney autopsy - Revision history

Mikael Häggström:

2022-12-04T14:55:17Z

← Older revision		Revision as of 10:55, 4 December 2022
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	{{Top		<noinclude>{{Top
	\|author1=[[User:Mikael Häggström\|Mikael Häggström]]		\|author1=[[User:Mikael Häggström\|Mikael Häggström]]
	\|author2=		\|author2=
	}}		}}
	{{Comprehensiveness}}		{{Comprehensiveness}}
			</noinclude>
	==Autopsy cutting==		==Autopsy cutting==
	[[File:Gross pathology of nephrosclerosis.jpg\|thumb\|210px\|A fine granular surface can be reported as '''nephrosclerosis''', and is associated with arteriosclerosis and glomerulosclerosis.<ref>{{cite web\|url=http://virtualhumanembryo.lsuhsc.edu/GIFT/pdf_files/PG_Kidney.pdf\|title=The Cadaver’s Kidney P.G.\|author=Guenevere Rae, Ph.D., William Newman, M.D., Supriya Donthamsetty, M.D., Robin McGoey, M.D.\|accessdate=2021-05-18}}</ref>]]		[[File:Gross pathology of nephrosclerosis.jpg\|thumb\|210px\|A fine granular surface can be reported as '''nephrosclerosis''', and is associated with arteriosclerosis and glomerulosclerosis.<ref>{{cite web\|url=http://virtualhumanembryo.lsuhsc.edu/GIFT/pdf_files/PG_Kidney.pdf\|title=The Cadaver’s Kidney P.G.\|author=Guenevere Rae, Ph.D., William Newman, M.D., Supriya Donthamsetty, M.D., Robin McGoey, M.D.\|accessdate=2021-05-18}}</ref>]]
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	*Findings and if they are consistent with already known diagnoses.		*Findings and if they are consistent with already known diagnoses.
	{{Further\|Autopsy}}		{{Further\|Autopsy}}
	{{Bottom}}		<noinclude>{{Bottom}}</noinclude>

Mikael Häggström: /* Diabetic nephropathy */ Better

2022-06-30T14:49:19Z

Diabetic nephropathy: Better

← Older revision		Revision as of 10:49, 30 June 2022
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	====Diabetic nephropathy====		====Diabetic nephropathy====
	[[File:Nodular_glomerulosclerosis.jpeg\|thumb\|~~Two glomeruli in diabetic nephropathy: the~~ acellular light purple ~~areas within the capillary tufts are the destructive~~ glomerular matrix deposits.]]		[[File:Nodular_glomerulosclerosis.jpeg\|thumb\|Nodular acellular light purple glomerular matrix deposits, typical of diabetic nephropathy.]]
	For alterations in glomerular matrix and/or cellularity, the most common cause is ''diabetic nephropathy'', and typically presents as glomerular enlargement, mesangial sclerosis, basement membrane thickening and and arteriolar hyalinosis.<ref name="PerroneChang2017"/>		For alterations in glomerular matrix and/or cellularity, the most common cause is ''diabetic nephropathy'', and typically presents as glomerular enlargement, mesangial sclerosis, basement membrane thickening and and arteriolar hyalinosis.<ref name="PerroneChang2017"/>

Mikael Häggström: /* Glomerular findings */ Also called

2022-05-17T17:10:58Z

Glomerular findings: Also called

← Older revision		Revision as of 13:10, 17 May 2022
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	<gallery mode=packed heights=180>		<gallery mode=packed heights=180>
	File:Nodular_glomerulosclerosis.jpeg\|'''Nodular''' glomerulosclerosis, prompting a consideration of [[#Diabetic nephropathy\|diabetic nephropathy, see section below.]]<ref name="PerroneChang2017"/>		File:Nodular_glomerulosclerosis.jpeg\|'''Nodular''' glomerulosclerosis, prompting a consideration of [[#Diabetic nephropathy\|diabetic nephropathy, see section below.]]<ref name="PerroneChang2017"/>
	File:Total hyalinization of a glomerulus.jpg\|A glomerulus with '''total hyalinization'''. People aged ≤40 should have less than 1% - 10% globally sclerotic glomeruli, and less than 30% by age 80.<ref name=abdominalkey>{{cite web\|url=https://abdominalkey.com/renal-disease-caused-by-hypertension/\|title=Renal Disease Caused by Hypertension\|author=Jean L. Olson\|website=Abdominal Key}} Citing: <br>- {{cite journal\| author=Kaplan C, Pasternack B, Shah H, Gallo G\| title=Age-related incidence of sclerotic glomeruli in human kidneys. \| journal=Am J Pathol \| year= 1975 \| volume= 80 \| issue= 2 \| pages= 227-34 \| pmid=51591 \| doi= \| pmc=1912918 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=51591 }}<br>- {{cite journal\|last1=Kappel\|first1=Birgitte\|last2=Olsen\|first2=Steen\|title=Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex\|journal=Virchows Archiv A Pathological Anatomy and Histology\|volume=387\|issue=3\|year=1980\|pages=271–277\|issn=0340-1227\|doi=10.1007/BF00454830}}</ref> An increased amount indicates mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]<ref name=abdominalkey/>		File:Total hyalinization of a glomerulus.jpg\|A glomerulus with '''total hyalinization''' (also called a '''globally sclerotic''' glomerulus). People aged ≤40 should have less than 1% - 10% globally sclerotic glomeruli, and less than 30% by age 80.<ref name=abdominalkey>{{cite web\|url=https://abdominalkey.com/renal-disease-caused-by-hypertension/\|title=Renal Disease Caused by Hypertension\|author=Jean L. Olson\|website=Abdominal Key}} Citing: <br>- {{cite journal\| author=Kaplan C, Pasternack B, Shah H, Gallo G\| title=Age-related incidence of sclerotic glomeruli in human kidneys. \| journal=Am J Pathol \| year= 1975 \| volume= 80 \| issue= 2 \| pages= 227-34 \| pmid=51591 \| doi= \| pmc=1912918 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=51591 }}<br>- {{cite journal\|last1=Kappel\|first1=Birgitte\|last2=Olsen\|first2=Steen\|title=Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex\|journal=Virchows Archiv A Pathological Anatomy and Histology\|volume=387\|issue=3\|year=1980\|pages=271–277\|issn=0340-1227\|doi=10.1007/BF00454830}}</ref> An increased amount indicates mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]<ref name=abdominalkey/>
	</gallery>		</gallery>
	*'''Mesangial hypercellularity''' (which has been defined as more than 3 cell nuclei per peripheral mesangial area on a 4-μm thick tissue section), prompting a consideration of [[#Diabetic nephropathy\|diabetic nephropathy, see section below.]]<ref name="PerroneChang2017"/>		*'''Mesangial hypercellularity''' (which has been defined as more than 3 cell nuclei per peripheral mesangial area on a 4-μm thick tissue section), prompting a consideration of [[#Diabetic nephropathy\|diabetic nephropathy, see section below.]]<ref name="PerroneChang2017"/>

Mikael Häggström: /* Microscopic evaluation */ Simple cyst

2021-12-08T20:44:17Z

Microscopic evaluation: Simple cyst

← Older revision		Revision as of 16:44, 8 December 2021
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	==Microscopic evaluation==		==Microscopic evaluation==
	[[File:Histopathology of renal autolysis.jpg\|thumb\|Kidney with substantial '''autolysis''', but otherwise being unremarkable.]]		[[File:Histopathology of renal autolysis.jpg\|thumb\|Kidney with substantial '''autolysis''', but otherwise being unremarkable.]]
			[[File:Histopathology of simple cyst of the kidney.jpg\|thumb\|The lining of a '''simple cyst''', with inconspicuous nuclei. They usually have a single layer of cuboidal, flattened or atrophic epithelium,<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/kidneytumorsimplecyst.html\|title=Simple cysts\|author=Mandolin S. Ziadie, M.D.\|website=Pathology Outlines}} Topic Completed: 1 November 2011. Minor changes: 1 October 2019</ref> but this case has a somewhat thicker fibrous layer.]]
	===Findings===		===Findings===
	The main findings to look for:<ref name="PerroneChang2017">{{cite journal\|last1=Perrone\|first1=Marie E\|last2=Chang\|first2=Anthony\|last3=Henriksen\|first3=Kammi J\|title=Medical renal diseases are frequent but often unrecognized in adult autopsies\|journal=Modern Pathology\|volume=31\|issue=2\|year=2017\|pages=365–373\|issn=0893-3952\|doi=10.1038/modpathol.2017.122}}</ref>		The main findings to look for:<ref name="PerroneChang2017">{{cite journal\|last1=Perrone\|first1=Marie E\|last2=Chang\|first2=Anthony\|last3=Henriksen\|first3=Kammi J\|title=Medical renal diseases are frequent but often unrecognized in adult autopsies\|journal=Modern Pathology\|volume=31\|issue=2\|year=2017\|pages=365–373\|issn=0893-3952\|doi=10.1038/modpathol.2017.122}}</ref>

Mikael Häggström: /* Microscopic evaluation */ Otherwise

2021-08-18T12:37:55Z

Microscopic evaluation: Otherwise

← Older revision		Revision as of 08:37, 18 August 2021
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	==Microscopic evaluation==		==Microscopic evaluation==
	[[File:Histopathology of renal autolysis.jpg\|thumb\|Kidney with substantial autolysis.]]		[[File:Histopathology of renal autolysis.jpg\|thumb\|Kidney with substantial '''autolysis''', but otherwise being unremarkable.]]
	===Findings===		===Findings===
	The main findings to look for:<ref name="PerroneChang2017">{{cite journal\|last1=Perrone\|first1=Marie E\|last2=Chang\|first2=Anthony\|last3=Henriksen\|first3=Kammi J\|title=Medical renal diseases are frequent but often unrecognized in adult autopsies\|journal=Modern Pathology\|volume=31\|issue=2\|year=2017\|pages=365–373\|issn=0893-3952\|doi=10.1038/modpathol.2017.122}}</ref>		The main findings to look for:<ref name="PerroneChang2017">{{cite journal\|last1=Perrone\|first1=Marie E\|last2=Chang\|first2=Anthony\|last3=Henriksen\|first3=Kammi J\|title=Medical renal diseases are frequent but often unrecognized in adult autopsies\|journal=Modern Pathology\|volume=31\|issue=2\|year=2017\|pages=365–373\|issn=0893-3952\|doi=10.1038/modpathol.2017.122}}</ref>

Mikael Häggström: /* Microscopic evaluation */ +Autolysis

2021-08-18T12:37:13Z

Microscopic evaluation: +Autolysis

← Older revision		Revision as of 08:37, 18 August 2021
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	==Microscopic evaluation==		==Microscopic evaluation==
			[[File:Histopathology of renal autolysis.jpg\|thumb\|Kidney with substantial autolysis.]]
	===Findings===		===Findings===
	The main findings to look for:<ref name="PerroneChang2017">{{cite journal\|last1=Perrone\|first1=Marie E\|last2=Chang\|first2=Anthony\|last3=Henriksen\|first3=Kammi J\|title=Medical renal diseases are frequent but often unrecognized in adult autopsies\|journal=Modern Pathology\|volume=31\|issue=2\|year=2017\|pages=365–373\|issn=0893-3952\|doi=10.1038/modpathol.2017.122}}</ref>		The main findings to look for:<ref name="PerroneChang2017">{{cite journal\|last1=Perrone\|first1=Marie E\|last2=Chang\|first2=Anthony\|last3=Henriksen\|first3=Kammi J\|title=Medical renal diseases are frequent but often unrecognized in adult autopsies\|journal=Modern Pathology\|volume=31\|issue=2\|year=2017\|pages=365–373\|issn=0893-3952\|doi=10.1038/modpathol.2017.122}}</ref>

Mikael Häggström: /* Vascular findings */ Indicating

2021-08-02T23:28:32Z

Vascular findings: Indicating

← Older revision		Revision as of 19:28, 2 August 2021
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	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]		File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
	File:Histopathology of renal arteriolar hyalinosis, annotated.jpg\|Histopathology of '''arteriolar hyalinosis''', being a component of ''nephroarteriolosclerosis''.		File:Histopathology of renal arteriolar hyalinosis, annotated.jpg\|Histopathology of '''arteriolar hyalinosis''', being a component of ''nephroarteriolosclerosis'', also indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
	File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis		File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
	File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.		File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.

Mikael Häggström: /* Vascular findings */ +Hyalinosis

2021-08-02T23:27:11Z

Vascular findings: +Hyalinosis

← Older revision		Revision as of 19:27, 2 August 2021
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	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]		File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
			File:Histopathology of renal arteriolar hyalinosis, annotated.jpg\|Histopathology of '''arteriolar hyalinosis''', being a component of ''nephroarteriolosclerosis''.
	File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis		File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
	File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.		File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.

Mikael Häggström: /* Vascular findings */ Unspecific

2021-06-07T23:44:30Z

Vascular findings: Unspecific

← Older revision		Revision as of 19:44, 7 June 2021
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	File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]		File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
	File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis		File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
	File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', ~~indicating mainly heart failure~~.		File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.
	</gallery>		</gallery>

Mikael Häggström: /* Vascular findings */ Better image

2021-05-21T16:21:52Z

Vascular findings: Better image

← Older revision		Revision as of 12:21, 21 May 2021
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	*'''Congestion'''		*'''Congestion'''
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:~~Fibrous intimal thickening in hypertensive nephropathy~~.jpg\|~~Fibrous intimal~~ thickening, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]		File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
	File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis		File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
	File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', indicating mainly heart failure.		File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', indicating mainly heart failure.

← Older revision		Revision as of 19:28, 2 August 2021
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	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]		File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
	File:Histopathology of renal arteriolar hyalinosis, annotated.jpg\|Histopathology of '''arteriolar hyalinosis''', being a component of ''nephroarteriolosclerosis''.		File:Histopathology of renal arteriolar hyalinosis, annotated.jpg\|Histopathology of '''arteriolar hyalinosis''', being a component of ''nephroarteriolosclerosis'', also indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
	File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis		File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
	File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.		File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.

← Older revision		Revision as of 19:27, 2 August 2021
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	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]		File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg\|thumb\|Intimal thickening with an onion skin-like appearance, indicating mainly [[#Hypertensive nephropathy\|hypertensive nephropathy, see section below.]]
			File:Histopathology of renal arteriolar hyalinosis, annotated.jpg\|Histopathology of '''arteriolar hyalinosis''', being a component of ''nephroarteriolosclerosis''.
	File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis		File:Histopathology of vasculitis in systemic sclerosis.jpg\|Histopathology of '''vasculitis''' (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
	File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.		File:Histopathology of glomerulus with congestion.jpg\|Glomerulus with '''congestion''', being an unspecific postmortem finding.