Peripheral blood smear - Revision history

Mikael Häggström: /* White blood cells */

2026-07-24T17:15:14Z

White blood cells

← Older revision		Revision as of 13:15, 24 July 2026
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	\|}		\|}
	;Burr cells versus spur cells		;Burr cells versus spur cells
	<gallery mode=packed heights=150>		<gallery mode="packed" heights="150">
	File:Micrograph of an echinocyte on a peripheral blood smear.jpg\|'''Burr cell''' (echinocyte)		File:Micrograph of an echinocyte on a peripheral blood smear.jpg\|'''Burr cell''' (echinocyte)
	File:Human blood film with acanthocytes 02.jpg\|'''Spur cell''' (acanthocyte)		File:Human blood film with acanthocytes 02.jpg\|'''Spur cell''' (acanthocyte)
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	;Intraerythrocytic findings		;Intraerythrocytic findings
	<gallery mode=packed heights=150>		<gallery mode="packed" heights="150">
	File:Micrograph of a red blood cells with an overlying platelet on a peripheral blood smear.jpg\|When seeing what appears to a platelet overlying a red blood cells (as pictured), confirm that there is a halo.		File:Micrograph of a red blood cells with an overlying platelet on a peripheral blood smear.jpg\|When seeing what appears to a platelet overlying a red blood cells (as pictured), confirm that there is a halo.
	File:Human blood film with babesia.jpg\|Otherwise, make sure it is not '''babesia''' (pictured) or malaria (images below).		File:Human blood film with babesia.jpg\|Otherwise, make sure it is not '''babesia''' (pictured) or malaria (images below).
	</gallery>		</gallery>
	<gallery mode=packed heights=250>		<gallery mode="packed" heights="250">
	File:Blood stages of P. falciparum over 48h.jpg\|'''Malaria''', showing appearance at different intraerythrocytic blood stages.		File:Blood stages of P. falciparum over 48h.jpg\|'''Malaria''', showing appearance at different intraerythrocytic blood stages.
	File:Thick blood film with Plasmodium falciparum rings and schizonts.png\|If '''malaria''' is suspected, also make a thick blood film.		File:Thick blood film with Plasmodium falciparum rings and schizonts.png\|If '''malaria''' is suspected, also make a thick blood film.
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	[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte. {{further\|Suspected blasts on peripheral blood smear}}]]		[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte. {{further\|Suspected blasts on peripheral blood smear}}]]
	A common practice is to evaluate at least 100 white blood cells. Look for:		A common practice is to evaluate at least 100 white blood cells. Look for:
	<gallery mode=packed heights=190>		<gallery mode="packed" heights="190">
	File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further\|Suspected blasts on peripheral blood smear}}		File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further\|Suspected blasts on peripheral blood smear}}
	File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>		File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>
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	! Type II<br />(plasma cell-like) - Most common		! Type II<br />(plasma cell-like) - Most common
	! Type III<br />(lymphoblast-like)		! Type III<br />(lymphoblast-like)
			\|-
			! Typical morphology
			\| [[File:Type 1 atypical lymphocyte.png\|180px\|center\|Type I (monocyte-like) atypical lymphocyte]]
			\| [[File:Type 2 atypical lymphocyte.png\|180px\|center\|Type II (plasma cell-like) atypical lymphocyte]]
			\| [[File:Type 3 atypical lymphocyte.png\|180px\|center\|Type III (lymphoblast-like) atypical lymphocyte]]
	\|-		\|-
	! Size		! Size
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	\| Azurophilic granules (±)		\| Azurophilic granules (±)
	\| —		\| —
	\|-
	~~! Typical morphology~~
	~~\| [[File:Type 1 atypical lymphocyte.png\|180px\|center\|Type I (monocyte-like) atypical lymphocyte]]~~
	~~\| [[File:Type 2 atypical lymphocyte.png\|180px\|center\|Type II (plasma cell-like) atypical lymphocyte]]~~
	~~\| [[File:Type 3 atypical lymphocyte.png\|180px\|center\|Type III (lymphoblast-like) atypical lymphocyte]]~~
	\|}		\|}

Mikael Häggström: /* White blood cells */ or reactive

2026-07-24T17:14:03Z

White blood cells: or reactive

← Older revision		Revision as of 13:14, 24 July 2026
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	{\| class="wikitable" style="text-align:center; vertical-align:middle;"		{\| class="wikitable" style="text-align:center; vertical-align:middle;"
	\|+ Atypical lymphocytes:<ref name="Nozaka2023">{{cite journal		\|+ Atypical/Reactive lymphocytes:<ref name="Nozaka2023">{{cite journal
	\|last1=Nozaka \|first1=Hiroyuki		\|last1=Nozaka \|first1=Hiroyuki
	\|last2=Kushibiki \|first2=Mihoko		\|last2=Kushibiki \|first2=Mihoko

Mikael Häggström: /* White blood cells */ +Atypical lymphs

2026-07-24T17:12:38Z

White blood cells: +Atypical lymphs

@@ Line 119: / Line 119: @@
 File:Smudge cell in a peripheral blood smear.jpg|When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web|url=http://www.captodayonline.com/Archives/0610/0610_qa.html|title=Q & A|website=CAP Today|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin.
 </gallery>
 ==Report==

Mikael Häggström: /* White blood cells */ number

2026-07-16T23:05:05Z

White blood cells: number

← Older revision		Revision as of 19:05, 16 July 2026
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	===White blood cells===		===White blood cells===
	[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte. {{further\|Suspected blasts on peripheral blood smear}}]]		[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte. {{further\|Suspected blasts on peripheral blood smear}}]]
	Look for:		A common practice is to evaluate at least 100 white blood cells. Look for:
	<gallery mode=packed heights=190>		<gallery mode=packed heights=190>
	File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further\|Suspected blasts on peripheral blood smear}}		File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further\|Suspected blasts on peripheral blood smear}}

Mikael Häggström: /* White blood cells */ Linked

2022-11-29T22:25:09Z

White blood cells: Linked

← Older revision		Revision as of 18:25, 29 November 2022
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	===White blood cells===		===White blood cells===
	[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte.]]		[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte. {{further\|Suspected blasts on peripheral blood smear}}]]
	Look for:		Look for:
	<gallery mode=packed heights=190>		<gallery mode=packed heights=190>
	File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). ~~If blast cells are found, estimate their percentage compared to all white~~ blood ~~cells.~~		File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). {{further\|Suspected blasts on peripheral blood smear}}
	File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>		File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>
	File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.		File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.

Mikael Häggström: Title

2022-09-15T20:43:43Z

Title

← Older revision		Revision as of 16:43, 15 September 2022
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	File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>		File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>
	File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.		File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.
	File:Smudge cell in a peripheral blood smear.jpg\|When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web\|url=http://www.captodayonline.com/Archives/0610/0610_qa.html\|website=CAP Today\|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin.		File:Smudge cell in a peripheral blood smear.jpg\|When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web\|url=http://www.captodayonline.com/Archives/0610/0610_qa.html\|title=Q & A\|website=CAP Today\|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin.
	</gallery>		</gallery>

Mikael Häggström: size

2022-05-19T22:53:35Z

size

← Older revision		Revision as of 18:53, 19 May 2022
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	File:Human blood film with babesia.jpg\|Otherwise, make sure it is not '''babesia''' (pictured) or malaria (images below).		File:Human blood film with babesia.jpg\|Otherwise, make sure it is not '''babesia''' (pictured) or malaria (images below).
	</gallery>		</gallery>
	<gallery mode=packed heights=~~220~~>		<gallery mode=packed heights=250>
	File:Blood stages of P. falciparum over 48h.jpg\|'''Malaria''', showing appearance at different intraerythrocytic blood stages.		File:Blood stages of P. falciparum over 48h.jpg\|'''Malaria''', showing appearance at different intraerythrocytic blood stages.
	File:Thick blood film with Plasmodium falciparum rings and schizonts.png\|If '''malaria''' is suspected, also make a thick blood film.		File:Thick blood film with Plasmodium falciparum rings and schizonts.png\|If '''malaria''' is suspected, also make a thick blood film.

Mikael Häggström: /* White blood cells */ Workup

2022-05-19T22:32:16Z

White blood cells: Workup

← Older revision		Revision as of 18:32, 19 May 2022
Line 114:		Line 114:
	Look for:		Look for:
	<gallery mode=packed heights=190>		<gallery mode=packed heights=190>
	File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus).		File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus). If blast cells are found, estimate their percentage compared to all white blood cells.
	File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>		File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>
	File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.		File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.

Mikael Häggström: /* White blood cells */ Integrated

2022-01-20T00:01:03Z

White blood cells: Integrated

← Older revision		Revision as of 20:01, 19 January 2022
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	File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>		File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>
	File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.		File:Prolymphocyte in peripheral blood smear.png\|In patients with known chronic lymphocytic leukemia, estimate the percentage of '''prolymphocytes''', which are medium-sized lymphocytes with prominent nucleoli.<ref>{{cite web\|url=https://imagebank.hematology.org/image/19922/prolymphocytes-in-pll?type=upload\|title=prolymphocytes in PLL\|website=American Society of Hematology\|date=2013-07-16}}</ref> A percentage of less than 5% can be reported as such.
			File:Smudge cell in a peripheral blood smear.jpg\|When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web\|url=http://www.captodayonline.com/Archives/0610/0610_qa.html\|website=CAP Today\|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin.
	</gallery>		</gallery>
	When '''smudge cells''' constitute more than 10% of white blood cells, or in patients with CLL, a separate smear with a drop of serum albumin to every four or five drops of blood should be made to stabilize cell membranes.<ref>{{cite web\|url=http://www.captodayonline.com/Archives/0610/0610_qa.html\|website=CAP Today\|author=Fredrick L. Kiechle}} June 2010</ref> A semi-quantification of different cell lines should then be made on the albumin slide, whereas white and red blood cell morphology should still be made on the original slide, since it is altered by albumin.

	==Report==		==Report==

Mikael Häggström: /* White blood cells */ heights

2022-01-19T23:56:35Z

White blood cells: heights

← Older revision		Revision as of 19:56, 19 January 2022
Line 113:		Line 113:
	[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte.]]		[[File:Monoblast, promonocyte and monocyte.jpg\|thumb\|400px\|Comparison of monoblast, promonocyte and monocyte.]]
	Look for:		Look for:
	<gallery mode=packed>		<gallery mode=packed heights=190>
	File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus).		File:Myeloblast with Auer rod.jpg\|thumb\|'''Blast cells''', generally having large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. This example has an Auer rod (to the left of the nucleus).
	File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>		File:Hypersegmented neutrophil.jpg\|'''Hypersegmented neutrophils'''. This is abnormal when more than half of neutrophils have at least 4 segments, or more than 5% of neutrophils have more than 5 segments.<ref name="Glassy 1998 p. ">{{cite book \| last=Glassy \| first=Eric \| title=Color atlas of hematology : an illustrated field guide based on proficiency testing \| publisher=College of American Patholgists \| publication-place=Northfield, Ill \| year=1998 \| isbn=978-0-930304-66-9 \| oclc=40976106 \| page=}}</ref>