Pheochromocytoma - Revision history

Mikael Häggström: /* Evaluation */ How to see

2022-03-01T23:03:12Z

Evaluation: How to see

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	[[File:Histopathology of pheochromocytoma.jpg\|thumb\|300px\|Typical features.<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html\|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma\|website=Pathology Outlines\|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]]		[[File:Histopathology of pheochromocytoma.jpg\|thumb\|300px\|Typical features.<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html\|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma\|website=Pathology Outlines\|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]]
	[[File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|thumb\|300px\|A pheochromocytoma with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells.]]		[[File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|thumb\|300px\|A pheochromocytoma with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells.]]
	Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells.		Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells. Sustentacular cells may be seen surrounding nests, as rather spindly cells.

	===Further workup===		===Further workup===

Mikael Häggström: +Image

2022-03-01T23:00:20Z

+Image

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	==Evaluation==		==Evaluation==
	[[File:Histopathology of pheochromocytoma.jpg\|thumb\|300px\|Typical features.<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html\|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma\|website=Pathology Outlines\|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]]		[[File:Histopathology of pheochromocytoma.jpg\|thumb\|300px\|Typical features.<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html\|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma\|website=Pathology Outlines\|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]]
			[[File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg\|thumb\|300px\|A pheochromocytoma with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells.]]
	Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells.		Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells.

Mikael Häggström: /* Evaluation */ +Image

2022-03-01T22:55:03Z

Evaluation: +Image

← Older revision		Revision as of 18:55, 1 March 2022
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	==Evaluation==		==Evaluation==
	~~Microscopy typically shows~~:<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html\|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma\|website=Pathology Outlines\|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>		[[File:Histopathology of pheochromocytoma.jpg\|thumb\|300px\|Typical features.<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html\|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma\|website=Pathology Outlines\|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]]
	*Architecture of nested (zellballen), trabecular or solid arrangement of tumor cells		Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells.
	*Tumor cells being large, polygonal, uniform or extensively vacuolated
	*Cytoplasm being abundant fine, granular and red-purple

	===Further workup===		===Further workup===

Mikael Häggström: Started

2022-03-01T21:57:54Z

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==Gross processing==
As per '''[[Adrenal tumors]]'''

==Evaluation==
Microscopy typically shows:<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma|website=Pathology Outlines|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>
*Architecture of nested (zellballen), trabecular or solid arrangement of tumor cells
*Tumor cells being large, polygonal, uniform or extensively vacuolated
*Cytoplasm being abundant fine, granular and red-purple

===Further workup===
For a diagnosis of pheochromocytoma, look for any adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures.

===Example report===
{|class=wikitable
| Right adrenal gland, resection:<br>Adrenal pheochromocytoma (3.0 cm tumor).<br>Surgical margins are negative for neoplasia.

(Optionally: Comment: This adrenal pheochromocytoma exhibits no adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures. Nonetheless, metastatic potential is difficult to predict based on histologic parameters.)
|}
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