Platelet aggregation study - Revision history

Mikael Häggström: sized

2022-08-01T22:53:06Z

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	[[File:First and second wave of platelet aggregation.png\|thumb\|On for example optical densitometry, a first and second wave of platelet aggregation is seen, in this case for an ADP-initiated aggregation.<ref name="JiangXu2013">{{cite journal\|last1=Jiang\|first1=L.\|last2=Xu\|first2=C.\|last3=Yu\|first3=S.\|last4=Liu\|first4=P.\|last5=Luo\|first5=D.\|last6=Zhou\|first6=Q.\|last7=Gao\|first7=C.\|last8=Hu\|first8=H.\|title=A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation\|journal=Journal of Thrombosis and Haemostasis\|volume=11\|issue=5\|year=2013\|pages=930–940\|issn=15387933\|doi=10.1111/jth.12168\|pmid=23406164\|doi-access=free}}</ref>]]		[[File:First and second wave of platelet aggregation.png\|thumb\|220px\|On for example optical densitometry, a first and second wave of platelet aggregation is seen, in this case for an ADP-initiated aggregation.<ref name="JiangXu2013">{{cite journal\|last1=Jiang\|first1=L.\|last2=Xu\|first2=C.\|last3=Yu\|first3=S.\|last4=Liu\|first4=P.\|last5=Luo\|first5=D.\|last6=Zhou\|first6=Q.\|last7=Gao\|first7=C.\|last8=Hu\|first8=H.\|title=A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation\|journal=Journal of Thrombosis and Haemostasis\|volume=11\|issue=5\|year=2013\|pages=930–940\|issn=15387933\|doi=10.1111/jth.12168\|pmid=23406164\|doi-access=free}}</ref>]]

	In a platelet aggregation study, the aggregation process is started by different agonists (ADP, epinephrine etc.) and the aggregation pattern can usually conform into any of the following patterns:		In a platelet aggregation study, the aggregation process is started by different agonists (ADP, epinephrine etc.) and the aggregation pattern can usually conform into any of the following patterns:

Mikael Häggström: Author

2021-12-11T01:06:23Z

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Mikael Häggström: Started

2021-12-11T01:04:56Z

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			[[File:First and second wave of platelet aggregation.png\|thumb\|On for example optical densitometry, a first and second wave of platelet aggregation is seen, in this case for an ADP-initiated aggregation.<ref name="JiangXu2013">{{cite journal\|last1=Jiang\|first1=L.\|last2=Xu\|first2=C.\|last3=Yu\|first3=S.\|last4=Liu\|first4=P.\|last5=Luo\|first5=D.\|last6=Zhou\|first6=Q.\|last7=Gao\|first7=C.\|last8=Hu\|first8=H.\|title=A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation\|journal=Journal of Thrombosis and Haemostasis\|volume=11\|issue=5\|year=2013\|pages=930–940\|issn=15387933\|doi=10.1111/jth.12168\|pmid=23406164\|doi-access=free}}</ref>]]

			In a platelet aggregation study, the aggregation process is started by different agonists (ADP, epinephrine etc.) and the aggregation pattern can usually conform into any of the following patterns:
	{\|class=wikitable align=center		{\|class=wikitable align=center
	\|+ ~~[[Platelet#Tests_of_function\|~~Platelet aggregation function]] by disorders and agonists ~~  {{Edit\|Template:Comprehensive table of platelet aggregation disorders and agonists}}~~		\|+ Platelet aggregation function by disorders and agonists
	! !! ~~[[Adenosine diphosphate\|~~ADP]] !! ~~[[Epinephrine (medication)\|~~Epinephrine]] !! [[Collagen]] !! [[Ristocetin]]		! !! ADP !! Epinephrine !! Collagen !! Ristocetin
	\|-		\|-
	! [[P2Y receptor]] defect<ref name="BorhanyPahore2010">{{cite journal\|last1=Borhany\|first1=Munira\|last2=Pahore\|first2=Zaen\|last3=ul Qadr\|first3=Zeeshan\|last4=Rehan\|first4=Muhammad\|last5=Naz\|first5=Arshi\|last6=Khan\|first6=Asif\|last7=Ansari\|first7=Saqib\|last8=Farzana\|first8=Tasneem\|last9=Nadeem\|first9=Muhammad\|last10=Raza\|first10=Syed Amir\|last11=Shamsi\|first11=Tahir\|title=Bleeding disorders in the tribe: result of consanguineous in breeding\|journal=Orphanet Journal of Rare Diseases\|volume=5\|issue=1\|year=2010\|issn=1750-1172\|doi=10.1186/1750-1172-5-23}}</ref> (including [[Clopidogrel]])		! P2Y receptor defect<ref name="BorhanyPahore2010">{{cite journal\|last1=Borhany\|first1=Munira\|last2=Pahore\|first2=Zaen\|last3=ul Qadr\|first3=Zeeshan\|last4=Rehan\|first4=Muhammad\|last5=Naz\|first5=Arshi\|last6=Khan\|first6=Asif\|last7=Ansari\|first7=Saqib\|last8=Farzana\|first8=Tasneem\|last9=Nadeem\|first9=Muhammad\|last10=Raza\|first10=Syed Amir\|last11=Shamsi\|first11=Tahir\|title=Bleeding disorders in the tribe: result of consanguineous in breeding\|journal=Orphanet Journal of Rare Diseases\|volume=5\|issue=1\|year=2010\|issn=1750-1172\|doi=10.1186/1750-1172-5-23}}</ref> (including Clopidogrel)
	\| '''Decreased''' \|\| Normal \|\| Normal \|\| Normal		\| '''Decreased''' \|\| Normal \|\| Normal \|\| Normal
	\|-		\|-
	! [[Adrenergic receptor]] defect<ref name="BorhanyPahore2010"/>		! Adrenergic receptor defect<ref name="BorhanyPahore2010"/>
	\| Normal \|\| '''Decreased''' \|\| Normal \|\| Normal		\| Normal \|\| '''Decreased''' \|\| Normal \|\| Normal
	\|-		\|-
	! [[Collagen receptor]] defect<ref name="BorhanyPahore2010"/>		! Collagen receptor defect<ref name="BorhanyPahore2010"/>
	\| Normal \|\| Normal \|\| '''Decreased or absent''' \|\| Normal		\| Normal \|\| Normal \|\| '''Decreased or absent''' \|\| Normal
	\|-		\|-
	!		!
	*[[Von Willebrand disease]]<ref name=Helena>{{cite web\|url=https://www.helena-biosciences.com/en/news/2015/why-perform-platelet-aggregation/\|title=Why Perform Platelet Aggregation?\|website=Helena Biosciences}} 2015</ref>		*Von Willebrand disease<ref name=Helena>{{cite web\|url=https://www.helena-biosciences.com/en/news/2015/why-perform-platelet-aggregation/\|title=Why Perform Platelet Aggregation?\|website=Helena Biosciences}} 2015</ref>
	*[[Bernard–Soulier syndrome]]<ref name="BorhanyPahore2010"/>		*Bernard–Soulier syndrome<ref name="BorhanyPahore2010"/>
	\| Normal \|\| Normal \|\| Normal \|\| '''Decreased or absent'''		\| Normal \|\| Normal \|\| Normal \|\| '''Decreased or absent'''
	\|-		\|-
	!		!
	*[[Glanzmann's thrombasthenia]]<ref name="BorhanyPahore2010"/>		*Glanzmann's thrombasthenia<ref name="BorhanyPahore2010"/>
	*~~[[Congenital afibrinogenemia\|~~Afibrinogenemia]]		*Afibrinogenemia
	\| '''Decreased''' \|\| '''Decreased''' \|\| '''Decreased''' \|\| Normal or '''decreased'''		\| '''Decreased''' \|\| '''Decreased''' \|\| '''Decreased''' \|\| Normal or '''decreased'''
	\|-		\|-
	! [[Platelet storage pool deficiency\|Storage pool deficiency]]<ref name=Helena/>		! Platelet storage pool deficiency\|Storage pool deficiency<ref name=Helena/>
	\|colspan=3 align=center\| '''Absent second wave''' \|\| '''Partial'''		\|colspan=3 align=center\| '''Absent second wave''' \|\| '''Partial'''
	\|-		\|-
	! [[Aspirin]] or aspirin-like disorder		! Aspirin or aspirin-like disorder
	\|colspan=2\| '''Absent second wave''' \|\| '''Absent''' \|\| Normal		\|colspan=2\| '''Absent second wave''' \|\| '''Absent''' \|\| Normal
	\|-		\|-

Mikael Häggström: Started

2021-12-11T00:50:28Z

Started

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{{Top
|author1=[[User:Mikael Häggström|Mikael Häggström]]
|author2=
}}
{|class=wikitable align=center
|+ [[Platelet#Tests_of_function|Platelet aggregation function]] by disorders and agonists   {{Edit|Template:Comprehensive table of platelet aggregation disorders and agonists}}
! !! [[Adenosine diphosphate|ADP]] !! [[Epinephrine (medication)|Epinephrine]] !! [[Collagen]] !! [[Ristocetin]]
|-
! [[P2Y receptor]] defect<ref name="BorhanyPahore2010">{{cite journal|last1=Borhany|first1=Munira|last2=Pahore|first2=Zaen|last3=ul Qadr|first3=Zeeshan|last4=Rehan|first4=Muhammad|last5=Naz|first5=Arshi|last6=Khan|first6=Asif|last7=Ansari|first7=Saqib|last8=Farzana|first8=Tasneem|last9=Nadeem|first9=Muhammad|last10=Raza|first10=Syed Amir|last11=Shamsi|first11=Tahir|title=Bleeding disorders in the tribe: result of consanguineous in breeding|journal=Orphanet Journal of Rare Diseases|volume=5|issue=1|year=2010|issn=1750-1172|doi=10.1186/1750-1172-5-23}}</ref> (including [[Clopidogrel]])
| '''Decreased''' || Normal || Normal || Normal
|-
! [[Adrenergic receptor]] defect<ref name="BorhanyPahore2010"/>
| Normal || '''Decreased''' || Normal || Normal
|-
! [[Collagen receptor]] defect<ref name="BorhanyPahore2010"/>
| Normal || Normal || '''Decreased or absent''' || Normal
|-
!
*[[Von Willebrand disease]]<ref name=Helena>{{cite web|url=https://www.helena-biosciences.com/en/news/2015/why-perform-platelet-aggregation/|title=Why Perform Platelet Aggregation?|website=Helena Biosciences}} 2015</ref>
*[[Bernard–Soulier syndrome]]<ref name="BorhanyPahore2010"/>
| Normal || Normal || Normal || '''Decreased or absent'''
|-
!
*[[Glanzmann's thrombasthenia]]<ref name="BorhanyPahore2010"/>
*[[Congenital afibrinogenemia|Afibrinogenemia]]
| '''Decreased''' || '''Decreased''' || '''Decreased''' || Normal or '''decreased'''
|-
! [[Platelet storage pool deficiency|Storage pool deficiency]]<ref name=Helena/>
|colspan=3 align=center| '''Absent second wave''' || '''Partial'''
|-
! [[Aspirin]] or aspirin-like disorder
|colspan=2| '''Absent second wave''' || '''Absent''' || Normal
|-
|}
==Further reading==
*[https://practical-haemostasis.com/ Practical-hemostasis.com]
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