Template:IHC of MMR - Revision history

Mikael Häggström: Scoring

2022-09-26T22:34:25Z

Scoring

← Older revision		Revision as of 18:34, 26 September 2022
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	</noinclude>~~{{Moderate-begin}}Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.{{Moderate-end}} They are scored~~ as:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal\|last1=Sarode\|first1=Venetia R.\|last2=Robinson\|first2=Linda\|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies\|journal=Archives of Pathology & Laboratory Medicine\|volume=143\|issue=10\|year=2019\|pages=1225–1233\|issn=0003-9985\|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal\| author=Sarode VR, Robinson L\| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. \| journal=Arch Pathol Lab Med \| year= 2019 \| volume= 143 \| issue= 10 \| pages= 1225-1233 \| pmid=30917047 \| doi=10.5858/arpa.2018-0201-OA \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal\| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS \| display-authors=etal\| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. \| journal=Biomedicines \| year= 2021 \| volume= 9 \| issue= 10 \| pages= \| pmid=34680502 \| doi=10.3390/biomedicines9101385 \| pmc=8533409 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref>		</noinclude>scoring is as follows:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal\|last1=Sarode\|first1=Venetia R.\|last2=Robinson\|first2=Linda\|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies\|journal=Archives of Pathology & Laboratory Medicine\|volume=143\|issue=10\|year=2019\|pages=1225–1233\|issn=0003-9985\|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal\| author=Sarode VR, Robinson L\| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. \| journal=Arch Pathol Lab Med \| year= 2019 \| volume= 143 \| issue= 10 \| pages= 1225-1233 \| pmid=30917047 \| doi=10.5858/arpa.2018-0201-OA \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal\| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS \| display-authors=etal\| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. \| journal=Biomedicines \| year= 2021 \| volume= 9 \| issue= 10 \| pages= \| pmid=34680502 \| doi=10.3390/biomedicines9101385 \| pmc=8533409 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref>
	<gallery mode=packed heights=190>		<gallery mode=packed heights=190>
	File:Immunohistochemistry of loss of expression of MLH-1.jpg\|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image)		File:Immunohistochemistry of loss of expression of MLH-1.jpg\|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image)

Mikael Häggström: Noinclude

2022-09-26T22:30:22Z

Noinclude

← Older revision		Revision as of 18:30, 26 September 2022
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	{{Moderate-begin}}Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.{{Moderate-end}} They are scored as:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal\|last1=Sarode\|first1=Venetia R.\|last2=Robinson\|first2=Linda\|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies\|journal=Archives of Pathology & Laboratory Medicine\|volume=143\|issue=10\|year=2019\|pages=1225–1233\|issn=0003-9985\|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal\| author=Sarode VR, Robinson L\| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. \| journal=Arch Pathol Lab Med \| year= 2019 \| volume= 143 \| issue= 10 \| pages= 1225-1233 \| pmid=30917047 \| doi=10.5858/arpa.2018-0201-OA \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal\| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS \| display-authors=etal\| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. \| journal=Biomedicines \| year= 2021 \| volume= 9 \| issue= 10 \| pages= \| pmid=34680502 \| doi=10.3390/biomedicines9101385 \| pmc=8533409 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref>		<noinclude>
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			</noinclude>{{Moderate-begin}}Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.{{Moderate-end}} They are scored as:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal\|last1=Sarode\|first1=Venetia R.\|last2=Robinson\|first2=Linda\|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies\|journal=Archives of Pathology & Laboratory Medicine\|volume=143\|issue=10\|year=2019\|pages=1225–1233\|issn=0003-9985\|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal\| author=Sarode VR, Robinson L\| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. \| journal=Arch Pathol Lab Med \| year= 2019 \| volume= 143 \| issue= 10 \| pages= 1225-1233 \| pmid=30917047 \| doi=10.5858/arpa.2018-0201-OA \| pmc= \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal\| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS \| display-authors=etal\| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. \| journal=Biomedicines \| year= 2021 \| volume= 9 \| issue= 10 \| pages= \| pmid=34680502 \| doi=10.3390/biomedicines9101385 \| pmc=8533409 \| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref>
	<gallery mode=packed heights=190>		<gallery mode=packed heights=190>
	File:Immunohistochemistry of loss of expression of MLH-1.jpg\|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image)		File:Immunohistochemistry of loss of expression of MLH-1.jpg\|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image)

Mikael Häggström: Templated

2022-09-26T22:29:18Z

Templated

New page

{{Moderate-begin}}Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.{{Moderate-end}} They are scored as:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal|last1=Sarode|first1=Venetia R.|last2=Robinson|first2=Linda|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies|journal=Archives of Pathology & Laboratory Medicine|volume=143|issue=10|year=2019|pages=1225–1233|issn=0003-9985|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal| author=Sarode VR, Robinson L| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. | journal=Arch Pathol Lab Med | year= 2019 | volume= 143 | issue= 10 | pages= 1225-1233 | pmid=30917047 | doi=10.5858/arpa.2018-0201-OA | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS | display-authors=etal| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. | journal=Biomedicines | year= 2021 | volume= 9 | issue= 10 | pages= | pmid=34680502 | doi=10.3390/biomedicines9101385 | pmc=8533409 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref>
<gallery mode=packed heights=190>
File:Immunohistochemistry of loss of expression of MLH-1.jpg|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image)
File:Immunohistochemistry of indeterminate expression of MSH-6.jpg|More than 0% but less than 10%: '''Indeterminate expression'''
File:Immunohistochemistry of retained expression of MSH-6.jpg|10% or more: '''Retained expression'''
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