Pigmented macrophages of the lung: Difference between revisions
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When seeing pigmented macrophages of the lung, | When seeing pigmented macrophages of the lung, categorize as follows: | ||
< | |||
File:Histopathology of anthracotic macrophage in lung, annotated.jpg| | {|class=wikitable | ||
File:Histopathology of pulmonary congestion and | ! Disease !! Macrophage name !! Macrophage pigment appearance (HE stain) !! Usual macrophage location || Associated medical history !! Image !! Other notes. | ||
</ | |- | ||
! Anthracosis | |||
| || Black-brown granules || Interstitium (perivascular) | |||
| | |||
*Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref> | |||
*Coal workers<ref>{{cite journal |author=Morgan WK |title=Industrial bronchitis |journal=Br J Ind Med |volume=35 |issue=4 |pages=285–91 |date=November 1978 |pmid=367424 |pmc=1008445 }}</ref> | |||
| [[File:Histopathology of anthracotic macrophage in lung, annotated.jpg|180px]] | |||
| In image, black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly. | |||
|- | |||
! Respiratory bronchiolitis | |||
| Smoker's macrophages | |||
| Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Airways (especially respiratory bronchioles) || Tobacco smoking | |||
| [[File:Histopathology of a smoker's macrophage.jpg|180px]] | |||
| Smoker's macrophage in center of image. Smoker's macrophages in alveoli is unspecific and does not confer a diagnosis of respiratory bronchiolitis. | |||
|- | |||
! '''Chronic pulmonary congestion''' | |||
| Siderophages || Brown-golden and refractile.<ref>{{cite book | last=Zander | first=Dani | title=Pulmonary pathology | publisher=Elsevier | publication-place=Philadelphia, PA | year=2018 | isbn=978-0-323-39308-9 | oclc=968711140}} - VII Acute Lung Injury with Siderophages</ref> | |||
| Alveoli<ref>{{cite book|author1= Guido Majno|author2=Isabelle Joris|title=Cells, Tissues, and Disease : Principles of General Pathology|url=https://books.google.com/books?id=8yAf6U7njlcC&pg=PA620|accessdate=19 March 2013|date=12 August 2004|publisher=Oxford University Press|isbn=978-0-19-974892-1|page=620}}</ref> | |||
| | |||
*Heart failure | |||
*Pulmonary hemorrhage | |||
| [[File:Histopathology of siderophage in chronic pulmonary congestion.jpg|180px]] | |||
| Image shows a siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening, indicating heart failure. | |||
|} | |||
[[File:Histopathology of smoker's macrophages with anthracotic stippling.jpg|thumb|Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and [[anthracosis]].]] | |||
{{Bottom}} | {{Bottom}} | ||
Latest revision as of 11:18, 21 May 2021
Author:
Mikael Häggström [note 1]
When seeing pigmented macrophages of the lung, categorize as follows:
| Disease | Macrophage name | Macrophage pigment appearance (HE stain) | Usual macrophage location | Associated medical history | Image | Other notes. |
|---|---|---|---|---|---|---|
| Anthracosis | Black-brown granules | Interstitium (perivascular) | 
|
In image, black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly. | ||
| Respiratory bronchiolitis | Smoker's macrophages | Yellow to light brown and finely granular[3] | Airways (especially respiratory bronchioles) | Tobacco smoking | 
|
Smoker's macrophage in center of image. Smoker's macrophages in alveoli is unspecific and does not confer a diagnosis of respiratory bronchiolitis. |
| Chronic pulmonary congestion | Siderophages | Brown-golden and refractile.[4] | Alveoli[5] |
|
|
Image shows a siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening, indicating heart failure. |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease . Philadelphia: W.B Saunders Company. ISBN 978-0-7216-7335-6.
- ↑ Morgan WK (November 1978). "Industrial bronchitis ". Br J Ind Med 35 (4): 285–91. PMID 367424.
- ↑ William Perry, M.D., M.P.H., Kristine Konopka, M.D.. Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis. Topic Completed: 1 July 2020. Minor changes: 1 July 2020.
- ↑ Zander, Dani (2018). Pulmonary pathology . Philadelphia, PA: Elsevier. ISBN 978-0-323-39308-9. OCLC 968711140. - VII Acute Lung Injury with Siderophages
- ↑ Guido Majno; Isabelle Joris (12 August 2004). Cells, Tissues, and Disease : Principles of General Pathology . Oxford University Press. p. 620. ISBN 978-0-19-974892-1. Retrieved on 19 March 2013.
Image sources