Pigmented macrophages of the lung: Difference between revisions

From patholines.org
Jump to navigation Jump to search
← Older edit
VisualWikitext
Mikael Häggström (talk | contribs)
Administrators, Editors, Image-reviewer, csmoderator, Interface administrators, Administrators, Upload Wizard campaign editors
7,148 edits
m Better
Mikael Häggström (talk | contribs)
Administrators, Editors, Image-reviewer, csmoderator, Interface administrators, Administrators, Upload Wizard campaign editors
7,148 edits
Noted
 
(5 intermediate revisions by the same user not shown)
Line 6: Line 6:


{|class=wikitable
{|class=wikitable
! Disease !! Macrophages !! Pigment appearance (HE stain) !! Associated medical history !! Image !! Image comment
! Disease !! Macrophage name !! Macrophage pigment appearance (HE stain) !! Usual macrophage location || Associated medical history !! Image !! Other notes.
|-
|-
! Anthracosis  
! Anthracosis  
|  || Black-brown granules
|  || Black-brown granules || Interstitium (perivascular)
|
|
*Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref>
*Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref>
*Coal workers<ref>{{cite journal |author=Morgan WK |title=Industrial bronchitis |journal=Br J Ind Med |volume=35 |issue=4 |pages=285–91 |date=November 1978 |pmid=367424 |pmc=1008445 }}</ref>
*Coal workers<ref>{{cite journal |author=Morgan WK |title=Industrial bronchitis |journal=Br J Ind Med |volume=35 |issue=4 |pages=285–91 |date=November 1978 |pmid=367424 |pmc=1008445 }}</ref>
| [[File:Histopathology of anthracotic macrophage in lung, annotated.jpg|200px]]
| [[File:Histopathology of anthracotic macrophage in lung, annotated.jpg|180px]]
| Black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly.
| In image, black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly.
|-
|-
! Respiratory bronchiolitis
! Respiratory bronchiolitis
| "Smoker's macrophages"
| Smoker's macrophages
| Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Tobacco smoking
| Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Airways (especially respiratory bronchioles) || Tobacco smoking
| [[File:Histopathology of a smoker's macrophage.jpg|200px]]
| [[File:Histopathology of a smoker's macrophage.jpg|180px]]
| Smoker's macrophages (arrow); mild interstitial lymphocytic infiltrate and mild fibrosis (arrowhead)<ref>{{cite journal|last1=Sousa|first1=Célia|last2=Rodrigues|first2=Márcio|last3=Carvalho|first3=André|last4=Viamonte|first4=Bárbara|last5=Cunha|first5=Rui|last6=Guimarães|first6=Susana|last7=de Moura|first7=Conceição Souto|last8=Morais|first8=António|last9=Pereira|first9=José Miguel|title=Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation|journal=Insights into Imaging|volume=10|issue=1|year=2019|issn=1869-4101|doi=10.1186/s13244-019-0765-z}}<br>- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref>
| Smoker's macrophage in center of image. Smoker's macrophages in alveoli is unspecific and does not confer a diagnosis of respiratory bronchiolitis.
|-
|-
! '''Chronic pulmonary congestion'''
! '''Chronic pulmonary congestion'''
| Siderophages || Brown-golden and refractile.<ref>{{cite book | last=Zander | first=Dani | title=Pulmonary pathology | publisher=Elsevier | publication-place=Philadelphia, PA | year=2018 | isbn=978-0-323-39308-9 | oclc=968711140}} - VII Acute Lung Injury with Siderophages</ref>
| Siderophages || Brown-golden and refractile.<ref>{{cite book | last=Zander | first=Dani | title=Pulmonary pathology | publisher=Elsevier | publication-place=Philadelphia, PA | year=2018 | isbn=978-0-323-39308-9 | oclc=968711140}} - VII Acute Lung Injury with Siderophages</ref>
| Alveoli<ref>{{cite book|author1= Guido Majno|author2=Isabelle Joris|title=Cells, Tissues, and Disease : Principles of General Pathology|url=https://books.google.com/books?id=8yAf6U7njlcC&pg=PA620|accessdate=19 March 2013|date=12 August 2004|publisher=Oxford University Press|isbn=978-0-19-974892-1|page=620}}</ref>
|
|
*Heart failure
*Heart failure
*Pulmonary hemorrhage
*Pulmonary hemorrhage
| [[File:Histopathology of siderophage in chronic pulmonary congestion.jpg|200px]]
| [[File:Histopathology of siderophage in chronic pulmonary congestion.jpg|180px]]
| Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening.
| Image shows a siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening, indicating heart failure.
|}
|}
[[File:Histopathology of smoker's macrophages with anthracotic stippling.jpg|thumb|Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and [[anthracosis]].]]
{{Bottom}}
{{Bottom}}

Latest revision as of 11:18, 21 May 2021

Author: Mikael Häggström [note 1]
When seeing pigmented macrophages of the lung, categorize as follows:

Disease Macrophage name Macrophage pigment appearance (HE stain) Usual macrophage location Associated medical history Image Other notes.
Anthracosis Black-brown granules Interstitium (perivascular)
  • Age and urban dwelling.[1]
  • Coal workers[2]
 In image, black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly.
Respiratory bronchiolitis Smoker's macrophages Yellow to light brown and finely granular[3] Airways (especially respiratory bronchioles) Tobacco smoking Smoker's macrophage in center of image. Smoker's macrophages in alveoli is unspecific and does not confer a diagnosis of respiratory bronchiolitis.
Chronic pulmonary congestion Siderophages Brown-golden and refractile.[4] Alveoli[5]
  • Heart failure
  • Pulmonary hemorrhage
 Image shows a siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening, indicating heart failure.
Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and anthracosis.

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease . Philadelphia: W.B Saunders Company. ISBN 978-0-7216-7335-6. 
  2. ↑ Morgan WK (November 1978). "Industrial bronchitis ". Br J Ind Med 35 (4): 285–91. PMID 367424. 
  3. ↑ William Perry, M.D., M.P.H., Kristine Konopka, M.D.. Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis. Topic Completed: 1 July 2020. Minor changes: 1 July 2020.
  4. ↑ Zander, Dani (2018). Pulmonary pathology . Philadelphia, PA: Elsevier. ISBN 978-0-323-39308-9. OCLC 968711140.  - VII Acute Lung Injury with Siderophages
  5. ↑ Guido Majno; Isabelle Joris (12 August 2004). Cells, Tissues, and Disease : Principles of General Pathology . Oxford University Press. p. 620. ISBN 978-0-19-974892-1. Retrieved on 19 March 2013. 

Image sources


Retrieved from "https://patholines.org/index.php?title=Pigmented_macrophages_of_the_lung&oldid=3545"