Urothelial versus squamous-cell carcinoma: Difference between revisions
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m Mikael Häggström moved page Urothelial versus squamous cell carcinoma to Urothelial versus squamous-cell carcinoma: consistency |
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==Microscopic examination== | ==Microscopic examination== | ||
*'''[[Urothelial carcinoma]] with squamous differentiation''' will have some [[urothelial carcinoma]] areas and some areas looking like [[ | *'''[[Urothelial carcinoma]] with squamous differentiation''' will have some [[urothelial carcinoma]] areas and some areas looking like [[squamous cell carcinoma of the skin]]. | ||
*'''Squamous cell carcinoma''' of the urinary bladder should not have areas appearing like urothelial carcinoma. | *'''Squamous cell carcinoma''' of the urinary bladder should not have areas appearing like urothelial carcinoma. | ||
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</gallery> | </gallery> | ||
In uncertain cases, perform immunohistochemistry for '''S100P''' and '''GATA3''', where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas ( | In uncertain cases, perform immunohistochemistry for '''S100P''' and '''GATA3''', where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas (positive in 9% and near-0%, respectively).<ref name="GulmannPaner2013">{{cite journal|last1=Gulmann|first1=Christian|last2=Paner|first2=Gladell P.|last3=Parakh|first3=Rugvedita S.|last4=Hansel|first4=Donna E.|last5=Shen|first5=Steven S.|last6=Ro|first6=Jae Y.|last7=Annaiah|first7=Chandrakanth|last8=Lopez-Beltran|first8=Antonio|last9=Rao|first9=Priya|last10=Arora|first10=Komal|last11=Cho|first11=Yong|last12=Herrera-Hernandez|first12=Loren|last13=Alsabeh|first13=Randa|last14=Amin|first14=Mahul B.|title=Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract|journal=Human Pathology|volume=44|issue=2|year=2013|pages=164–172|issn=00468177|doi=10.1016/j.humpath.2012.05.018}}</ref> | ||
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Latest revision as of 09:31, 26 April 2022
Author:
Mikael Häggström [note 1]
Gross processing
- As per urinary bladder
Microscopic examination
- Urothelial carcinoma with squamous differentiation will have some urothelial carcinoma areas and some areas looking like squamous cell carcinoma of the skin.
- Squamous cell carcinoma of the urinary bladder should not have areas appearing like urothelial carcinoma.
-
Urothelial carcinoma with squamous differentiation. -
Squamous cell carcinoma of the urinary bladder.
In uncertain cases, perform immunohistochemistry for S100P and GATA3, where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas (positive in 9% and near-0%, respectively).[1]
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Gulmann, Christian; Paner, Gladell P.; Parakh, Rugvedita S.; Hansel, Donna E.; Shen, Steven S.; Ro, Jae Y.; Annaiah, Chandrakanth; Lopez-Beltran, Antonio; et al. (2013). "Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract ". Human Pathology 44 (2): 164–172. doi:. ISSN 00468177.
Image sources