Urothelial versus squamous-cell carcinoma: Difference between revisions

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==Microscopic examination==
==Microscopic examination==
*'''[[Urothelial carcinoma]] with squamous differentiation''' will have some [[urothelial carcinoma]] areas and some areas looking like [[squanous cell carcinoma of the skin]].
*'''[[Urothelial carcinoma]] with squamous differentiation''' will have some [[urothelial carcinoma]] areas and some areas looking like [[squamous cell carcinoma of the skin]].
*'''Squamous cell carcinoma''' of the urinary bladder should not have areas appearing like urothelial carcinoma.
*'''Squamous cell carcinoma''' of the urinary bladder should not have areas appearing like urothelial carcinoma.


Latest revision as of 09:31, 26 April 2022

Author: Mikael Häggström [note 1]

Gross processing

Microscopic examination

  • Urothelial carcinoma with squamous differentiation.
    Urothelial carcinoma with squamous differentiation.
  • Squamous cell carcinoma of the urinary bladder.
    Squamous cell carcinoma of the urinary bladder.

In uncertain cases, perform immunohistochemistry for S100P and GATA3, where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas (positive in 9% and near-0%, respectively).[1]

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Gulmann, Christian; Paner, Gladell P.; Parakh, Rugvedita S.; Hansel, Donna E.; Shen, Steven S.; Ro, Jae Y.; Annaiah, Chandrakanth; Lopez-Beltran, Antonio; et al. (2013). "Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract ". Human Pathology 44 (2): 164–172. doi:10.1016/j.humpath.2012.05.018. ISSN 00468177. 

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