Liver tumor: Difference between revisions

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<noinclude>A [[tumor]] of the [[liver]]:</noinclude>
==Tissue sampling==
==Tissue sampling==
*Liver biopsy
*Liver biopsy
Line 17: Line 18:


==Microscopic evaluation==
==Microscopic evaluation==
[[File:Liver tumor types in adults by relative incidence.png|thumb|Liver tumor types by relative incidence in adults in the United States.<ref name=Sternberg>[https://basicmedicalkey.com/masses-of-the-liver-2/ Table 37.2] in: {{cite book | last=Sternberg | first=Stephen | title=Sternberg's diagnostic surgical pathology | publisher=LWW | publication-place=Place of publication not identified | year=2012 | isbn=978-1-4511-5289-0 | oclc=953861627 | ref=harv}}</ref>]]
[[File:Histopathology of a bile duct hamartoma, high magnification.jpg|thumb|220px|A '''bile duct hamartoma''' is also very common.<ref name="YangZhang2017">{{cite journal|last1=Yang|first1=Xiao-Yu|last2=Zhang|first2=Hai-Bo|last3=Wu|first3=Bin|last4=Li|first4=Ai-Jun|last5=Fu|first5=Xiao-Hui|title=Surgery is the preferred treatment for bile duct hamartomas|journal=Molecular and Clinical Oncology|volume=7|issue=4|year=2017|pages=649–653|issn=2049-9450|doi=10.3892/mco.2017.1354}}</ref> This image shows typical features:<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/livermeyenburgcomplex.html|title=Liver & intrahepatic bile ducts - Developmental anomalies / cysts - Von Meyenburg complex|author=Upasana Joneja, M.D.|website=Pathology Outlines}} Topic Completed: 23 November 2020. Minor changes: 23 November 2020</ref> <br>- Small to medium sized, irregularly shaped bile ducts lined by bland cuboidal  epithelium (may also be flattened).<br>- Prominent intervening collagenous stroma. <br>- Bile ducts containing eosinophilic debris (may also contain inspissated bile)]]
Hepatocellular carcinoma is the most common diagnosis for liver tumors,<ref name=Sternberg/> so start by looking for characteristics thereof.
<gallery mode=packed heights=200>
File:Liver tumor types in adults by relative incidence.png|Liver tumor types by relative incidence in adults in the United States.<ref name=Sternberg>[https://basicmedicalkey.com/masses-of-the-liver-2/ Table 37.2] in: {{cite book | last=Sternberg | first=Stephen | title=Sternberg's diagnostic surgical pathology | publisher=LWW | publication-place=Place of publication not identified | year=2012 | isbn=978-1-4511-5289-0 | oclc=953861627 | ref=harv}}</ref>
File:Hepatocellular carcinoma (14083110265).jpg|'''[[Hepatocellular carcinoma]]''', typically resembling hepatocytes, with abundant granular eosinophilic cytoplasm.
File:Histopathology of inflammatory hepatocellular adenoma.jpg|'''Hepatocellular adenoma''' (inflammatory type pictured) may have minor atypia.<ref>[https://www.hindawi.com/journals/ijh/2013/253261/fig7/ Figure 7] from {{cite journal|last1=Bioulac-Sage|first1=Paulette|last2=Sempoux|first2=Christine|last3=Possenti|first3=Laurent|last4=Frulio|first4=Nora|last5=Laumonier|first5=Hervé|last6=Laurent|first6=Christophe|last7=Chiche|first7=Laurence|last8=Frédéric Blanc|first8=Jean|last9=Saric|first9=Jean|last10=Trillaud|first10=Hervé|last11=Le Bail|first11=Brigitte|last12=Balabaud|first12=Charles|title=Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context|journal=International Journal of Hepatology|volume=2013|year=2013|pages=1–13|issn=2090-3448|doi=10.1155/2013/253261}}<br>- [https://creativecommons.org/licenses/by/3.0/ Attribution 3.0 Unported (CC BY 3.0) license]</ref>
</gallery>
{{Further|Evaluation of suspected malignancies}}
{{Further|Evaluation of suspected malignancies}}
{{Bottom}}
{{Bottom}}

Latest revision as of 15:03, 19 June 2022

Author: Mikael Häggström [note 1]
A tumor of the liver:

Tissue sampling

  • Liver biopsy
  • Autopsy: Further information: Autopsy

Gross examination

Note the following:[1]

  • Whether the tumor is sell demarcated from surrounding tissue
  • Whether there is visible infiltration or invasion into surrounding tissue
  • Any necrosis or bleeding
  • Hepatocellular carcinoma
    Hepatocellular carcinoma

Microscopic evaluation

A bile duct hamartoma is also very common.[2] This image shows typical features:[3]
- Small to medium sized, irregularly shaped bile ducts lined by bland cuboidal epithelium (may also be flattened).
- Prominent intervening collagenous stroma.
- Bile ducts containing eosinophilic debris (may also contain inspissated bile)
  • Liver tumor types by relative incidence in adults in the United States.[4]
    Liver tumor types by relative incidence in adults in the United States.[4]
  • Hepatocellular carcinoma, typically resembling hepatocytes, with abundant granular eosinophilic cytoplasm.
    Hepatocellular carcinoma, typically resembling hepatocytes, with abundant granular eosinophilic cytoplasm.
  • Hepatocellular adenoma (inflammatory type pictured) may have minor atypia.[5]
    Hepatocellular adenoma (inflammatory type pictured) may have minor atypia.[5]

Further information: Evaluation of suspected malignancies

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ . General oncology. Amboss. Retrieved on 2020-01-29.
  2. ↑ Yang, Xiao-Yu; Zhang, Hai-Bo; Wu, Bin; Li, Ai-Jun; Fu, Xiao-Hui (2017). "Surgery is the preferred treatment for bile duct hamartomas ". Molecular and Clinical Oncology 7 (4): 649–653. doi:10.3892/mco.2017.1354. ISSN 2049-9450. 
  3. ↑ Upasana Joneja, M.D.. Liver & intrahepatic bile ducts - Developmental anomalies / cysts - Von Meyenburg complex. Pathology Outlines. Topic Completed: 23 November 2020. Minor changes: 23 November 2020
  4. ↑ Table 37.2 in: Sternberg, Stephen (2012). Sternberg's diagnostic surgical pathology . Place of publication not identified: LWW. ISBN 978-1-4511-5289-0. OCLC 953861627. 
  5. ↑ Figure 7 from Bioulac-Sage, Paulette; Sempoux, Christine; Possenti, Laurent; Frulio, Nora; Laumonier, Hervé; Laurent, Christophe; Chiche, Laurence; Frédéric Blanc, Jean; et al. (2013). "Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context ". International Journal of Hepatology 2013: 1–13. doi:10.1155/2013/253261. ISSN 2090-3448. 
    - Attribution 3.0 Unported (CC BY 3.0) license

Image sources


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