Fundic gland polyp: Difference between revisions
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|author1=[[User:Mikael Häggström|Mikael Häggström]] | |author1=[[User:Mikael Häggström|Mikael Häggström]] | ||
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==Presentation== | ==Presentation== | ||
*Mainly '''[[gastric polyp]]'''. | *Mainly '''[[gastric polyp]]'''. | ||
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==Microscopic evaluation== | ==Microscopic evaluation== | ||
<gallery mode=packed heights=200> | <gallery mode=packed heights=200> | ||
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==Workup== | ==Workup== | ||
<gallery mode=packed heights=200> | <gallery mode=packed heights=200> | ||
File:Histopathology of a fundic gland polyp with dysplasia.jpg|Look for '''dysplasia''' (center), compared to normal mucosa (at right).{{MH}} | File:Histopathology of a fundic gland polyp with dysplasia.jpg|Look for '''dysplasia''' (center), compared to normal mucosa (at right). {{MH}} | ||
</gallery> | </gallery> | ||
{{ | Dysplasia in fundic gland polyp is mainly seen as nuclear enlargement, hyperchromasia, pseudostratification, and loss of cytoplasmic mucin.<ref name="pmid26386080">{{cite journal| author=Levy MD, Bhattacharya B| title=Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior. | journal=Am J Clin Pathol | year= 2015 | volume= 144 | issue= 4 | pages= 592-600 | pmid=26386080 | doi=10.1309/AJCPGK8QTYPUQJYL | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26386080 }} </ref> However, you don't need to spend much effort in the decision, since these patients have an excellent prognosis whether there is dysplasia or not. | ||
==Reporting== | ==Reporting== | ||
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Latest revision as of 19:29, 2 December 2022
Author:
Mikael Häggström [note 1]
Presentation
- Mainly gastric polyp.
Microscopic evaluation
-
A fundic gland polyp displays cystically dilated glands lined by chief cells and parietal cells, and possibly also mucinous foveolar cells.[1]
-
A fundic gland polyp, low magnification.[image 1]
![A fundic gland polyp displays cystically dilated glands lined by chief cells and parietal cells, and possibly also mucinous foveolar cells.[1]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_fundic_gland_polyp,_high_magnification,_annotated.jpg){kind=link}
![A fundic gland polyp, low magnification.[image 1]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_a_fundic_glad_polyp,_low_magnification.jpg){kind=link}
Differential diagnosis
-
Gastric hyperplastic polyp: Elongated, tortuous, and cystic foveolae separated by edematous and inflamed stroma.[2]
-
Gastric hyperplastic polyp, high magnification, showing the edematous and inflamed stroma.
![Gastric hyperplastic polyp: Elongated, tortuous, and cystic foveolae separated by edematous and inflamed stroma.[2]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_a_gastric_hyperplastic_polyp.jpg){kind=link}
Workup
-
Look for dysplasia (center), compared to normal mucosa (at right). [image 1]
![Look for dysplasia (center), compared to normal mucosa (at right). [image 1]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_a_fundic_gland_polyp_with_dysplasia.jpg){kind=link}
Dysplasia in fundic gland polyp is mainly seen as nuclear enlargement, hyperchromasia, pseudostratification, and loss of cytoplasmic mucin.[3] However, you don't need to spend much effort in the decision, since these patients have an excellent prognosis whether there is dysplasia or not.
Reporting
Generally, keep it short:
| (Stomach, excision:) Fundic gland polyp |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Naziheh Assarzadegan, M.D., Raul S. Gonzalez, M.D.. Stomach Polyps - Fundic gland polyp. PathologyOutlines. Topic Completed: 1 November 2017. Minor changes: 11 December 2019
- ↑ Groisman, Gabriel M.; Depsames, Roman; Ovadia, Baruch; Meir, Alona (2014). "Metastatic Carcinoma Occurring in a Gastric Hyperplastic Polyp Mimicking Primary Gastric Cancer: The First Reported Case
". Case Reports in Pathology 2014: 1–5. doi:. ISSN 2090-6781.
- Attribution 3.0 Unported (CC BY 3.0) license - ↑ Levy MD, Bhattacharya B (2015). "Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior. ". Am J Clin Pathol 144 (4): 592-600. doi:. PMID 26386080. Archived from the original. .
Image sources
- ↑ 1.0 1.1 Image(s) by: Mikael Häggström, M.D. Public Domain
- Author info
- Reusing images