Ruptured intercalated discs: Difference between revisions
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|author1=[[User:Mikael Häggström|Mikael Häggström]] | |author1=[[User:Mikael Häggström|Mikael Häggström]] | ||
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[[File:Histopathology of ruptured intercalated discs.jpg|thumb|Ruptured intercalated discs, in this case regarded as a visual artifact, and was not reported.]] | [[File:Histopathology of ruptured intercalated discs.jpg|thumb|Ruptured intercalated discs, in this case regarded as a visual artifact, and was not reported.]] | ||
Ruptured intercalated discs of myocytes of the '''[[heart]]''' have two main causes: | Ruptured intercalated discs of myocytes of the '''[[heart]]''' have two main causes: | ||
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*Square-shaped myocardiocyte nuclei. | *Square-shaped myocardiocyte nuclei. | ||
*Hyperdistended myocardiocytes with detached sarcomeres, and in proximity of hypercontracted myocardiocytes. | *Hyperdistended myocardiocytes with detached sarcomeres, and in proximity of hypercontracted myocardiocytes. | ||
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File:Free nuclei from myocardiocytes.jpg|Cases with ruptured intercalated discs often also display free myocardial nuclei or nuclear fragments, which should not be confused with a lymphocytic infiltrate. | |||
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Latest revision as of 10:54, 4 December 2022
Author:
Mikael Häggström [note 1]
Ruptured intercalated discs of myocytes of the heart have two main causes:
- Microtome processing, thereby being a visual artifact,[1] not needing reporting.
- Forceful myocardial contraction, at least in case of heart autopsy. This is mainly caused by ventricular fibrillation[2] or electric shock,[3]
If a lab often cause it as a visual artifact, it may be ignored in the report.[notes 1] If not, look for signs indicating forceful myocardial contraction, and thereby the mentioning of the findings in the report. Such signs are:[2][3]
- Alternating bundles of hypercontracted myocytes with hyperdistended ones.
- Square-shaped myocardiocyte nuclei.
- Hyperdistended myocardiocytes with detached sarcomeres, and in proximity of hypercontracted myocardiocytes.
-
Cases with ruptured intercalated discs often also display free myocardial nuclei or nuclear fragments, which should not be confused with a lymphocytic infiltrate.
Notes
- ↑ Repeated artifacts from a lab motivates measures to improve techniques.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Page 38 in: Giorgio Baroldi (2004). The Etiopathogenesis of Coronary Heart Disease: A Heretical Theory Based on Morphology, Second Edition . CRC Press. ISBN 9781498712811.
- ↑ 2.0 2.1 Page 55 in: Vittorio Fineschi, Giorgio Baroldi, Malcolm D. Silver (2016). Pathology of the Heart and Sudden Death in Forensic Medicine . CRC Press. ISBN 9781420006438.
- ↑ 3.0 3.1 Fineschi, Vittorio; Karch, Steven B.; D'Errico, Stefano; Pomara, Cristoforo; Riezzo, Irene; Turillazzi, Emanuela (2005). "Cardiac pathology in death from electrocution ". International Journal of Legal Medicine 120 (2): 79–82. doi:. ISSN 0937-9827.
Image sources