Fibrocystic breast changes: Difference between revisions
Jump to navigation
Jump to search
m </noinclude> |
m Better |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 8: | Line 8: | ||
==Microscopic examination== | ==Microscopic examination== | ||
Types: | Types: | ||
<gallery mode=packed> | <gallery mode=packed heights=220> | ||
File:Histopathology of sclerosing adenosis of the breast.jpg|'''Sclerosing adenosis''', with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.<ref name=PathologyOutlines>{{cite web|url=https://www.pathologyoutlines.com/topic/breastsclerosingadenosis.html|title=Breast - Fibrocystic changes - Sclerosing adenosis|author=Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.|website=Pathology Outlines}} Topic Completed: 1 January 2015. Minor changes: 31 December 2020</ref> | File:Histopathology of sclerosing adenosis of the breast.jpg|'''Sclerosing adenosis''', with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.<ref name=PathologyOutlines-fibrocystic>{{cite web|url=https://www.pathologyoutlines.com/topic/breastsclerosingadenosis.html|title=Breast - Fibrocystic changes - Sclerosing adenosis|author=Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.|website=Pathology Outlines}} Topic Completed: 1 January 2015. Minor changes: 31 December 2020</ref> | ||
File:Histopathology of | File:Histopathology of radial scar, low magnification.jpg|A '''radial scar''' of the breast, seen as a fibroelastic stroma and entrapped glands radiating outward. | ||
</gallery> | </gallery> | ||
===Differential diagnosis=== | ===Differential diagnosis=== | ||
Sclerosing adenosis may look similar to [[invasive ductal carcinoma]] (IDC), but IDC will:<ref name=PathologyOutlines/> | Sclerosing adenosis may look similar to [[invasive ductal carcinoma]] (IDC), but IDC will:<ref name=PathologyOutlines-fibrocystic/> | ||
*Not be lobular at low power | *Not be lobular at low power | ||
*Have marked cellular atypia | *Have marked cellular atypia | ||
| Line 21: | Line 21: | ||
When unsure, perform immunohistochemistry for myoepithelial markers (preferably '''p63''' and '''calponin''' in breast lesions): | When unsure, perform immunohistochemistry for myoepithelial markers (preferably '''p63''' and '''calponin''' in breast lesions): | ||
[[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] | [[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] | ||
<noinclude> | |||
{{Bottom}} | {{Bottom}} | ||
</noinclude> | |||
Latest revision as of 17:10, 16 October 2023
Author:
Mikael Häggström [note 1]
Presentations
Microscopic examination
Types:
-
![Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1]](https://upload.wikimedia.org/wikipedia/commons/thumb/0/05/Histopathology_of_sclerosing_adenosis_of_the_breast.jpg/500px-Histopathology_of_sclerosing_adenosis_of_the_breast.jpg?utm_source=commons.wikimedia.org&utm_campaign=imageinfo&utm_content=thumbnail)
Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1] -
A radial scar of the breast, seen as a fibroelastic stroma and entrapped glands radiating outward.
![Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1]](/File:Histopathology_of_sclerosing_adenosis_of_the_breast.jpg)
Differential diagnosis
Sclerosing adenosis may look similar to invasive ductal carcinoma (IDC), but IDC will:[1]
- Not be lobular at low power
- Have marked cellular atypia
- Have no myoepithelial cells surrounding ducts.
When unsure, perform immunohistochemistry for myoepithelial markers (preferably p63 and calponin in breast lesions):
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.. Breast - Fibrocystic changes - Sclerosing adenosis. Pathology Outlines. Topic Completed: 1 January 2015. Minor changes: 31 December 2020
Image sources