Template:Mitotic count in invasive breast cancer: Difference between revisions

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}}</noinclude>[[File:Mitosis appearances in breast cancer.jpg|thumb|Mitosis appearances in breast cancer]]
}}</noinclude>[[File:Mitosis appearances in breast cancer.jpg|thumb|Mitosis appearances in breast cancer]]
{{edit|Template:Mitotic count in invasive breast cancer}}<br>
{{edit|Template:Mitotic count in invasive breast cancer}}<br>
Mitotic figures are counted only at the periphery of the tumor, and counting should begin in the most mitotically active areas, and in at least 10 high-power fields (HPFs). If you know that the area of your high power field is about 0.2mm<sup>2</sup>, then you may score mitotic count as follows:<ref name=cap-invasive>{{cite web|url=https://documents.cap.org/protocols/Breast.Invasive_4.7.0.1.REL_CAPCP.pdf|Protocol for the Examination of Resection Specimens from Patients with Invasive Carcinoma of the Breast Version: 4.7.0.1 - Table 1. Score Categories According to Field Diameter and Mitotic Count|website=College of American Pathologists}} Protocol Posting Date: September 2022</ref>
Mitotic figures are counted only at the periphery of the tumor, and counting should begin in the most mitotically active areas, and in at least 10 high-power fields (HPFs). If you know that the area of your high power field is about 0.2mm<sup>2</sup>, then you may score mitotic count as follows:<ref name=cap-invasive>{{cite web|url=https://documents.cap.org/protocols/Breast.Invasive_4.7.0.1.REL_CAPCP.pdf|title=Protocol for the Examination of Resection Specimens from Patients with Invasive Carcinoma of the Breast Version: 4.7.0.1 - Table 1. Score Categories According to Field Diameter and Mitotic Count|website=College of American Pathologists}} Protocol Posting Date: September 2022</ref>
*'''1 point''': ≤7 mitoses per 10 HPFs   
*'''1 point''': ≤7 mitoses per 10 HPFs   
*'''2 points''': 8 to 14 mitoses per 10 HPFs
*'''2 points''': 8 to 14 mitoses per 10 HPFs
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*'''2 points''': 4 to 7 mitoses per mm<sup>2</sup>  
*'''2 points''': 4 to 7 mitoses per mm<sup>2</sup>  
*'''3 points''': ≥7 mitoses per mm<sup>2</sup>  
*'''3 points''': ≥7 mitoses per mm<sup>2</sup>  
A table of counts for various HPF sizes is available at the College of American Pathologists. [https://www.cap.org/wp-content/uploads/2026/06/Breast.Invasive.Bx_1.3.0.0.REL_CAPCP.pdf] (Page 8)<noinclude>
A table of counts for various HPF sizes is available in notes below.<ref group="note">
{| class="wikitable"
|+ Table 1. Score categories according to field diameter and mitotic count
! rowspan="2" | Field diameter (mm)
! rowspan="2" | Area (mm²)
! colspan="3" | Number of mitoses per 10 fields corresponding to:
|-
! Score 1
! Score 2
! Score 3
|-
| 0.40 || 0.125 || ≤4 || 5 to 9 || ≥10
|-
| 0.41 || 0.132 || ≤4 || 5 to 9 || ≥10
|-
| 0.42 || 0.139 || ≤5 || 6 to 10 || ≥11
|-
| 0.43 || 0.145 || ≤5 || 6 to 10 || ≥11
|-
| 0.44 || 0.152 || ≤5 || 6 to 11 || ≥12
|-
| 0.45 || 0.159 || ≤5 || 6 to 11 || ≥12
|-
| 0.46 || 0.166 || ≤6 || 7 to 12 || ≥13
|-
| 0.47 || 0.173 || ≤6 || 7 to 12 || ≥13
|-
| 0.48 || 0.181 || ≤6 || 7 to 13 || ≥14
|-
| 0.49 || 0.189 || ≤6 || 7 to 13 || ≥14
|-
| 0.50 || 0.196 || ≤7 || 8 to 14 || ≥15
|-
| 0.51 || 0.204 || ≤7 || 8 to 14 || ≥15
|-
| 0.52 || 0.212 || ≤7 || 8 to 15 || ≥16
|-
| 0.53 || 0.221 || ≤8 || 9 to 16 || ≥17
|-
| 0.54 || 0.229 || ≤8 || 9 to 16 || ≥17
|-
| 0.55 || 0.238 || ≤8 || 9 to 17 || ≥18
|-
| 0.56 || 0.246 || ≤8 || 9 to 17 || ≥18
|-
| 0.57 || 0.255 || ≤9 || 10 to 18 || ≥19
|-
| 0.58 || 0.264 || ≤9 || 10 to 19 || ≥20
|-
| 0.59 || 0.273 || ≤9 || 10 to 19 || ≥20
|-
| 0.60 || 0.283 || ≤10 || 11 to 20 || ≥21
|-
| 0.61 || 0.292 || ≤10 || 11 to 21 || ≥22
|-
| 0.62 || 0.302 || ≤11 || 12 to 22 || ≥23
|-
| 0.63 || 0.312 || ≤11 || 12 to 22 || ≥23
|-
| 0.64 || 0.322 || ≤11 || 12 to 23 || ≥24
|-
| 0.65 || 0.332 || ≤12 || 13 to 24 || ≥25
|-
| 0.66 || 0.342 || ≤12 || 13 to 24 || ≥25
|-
| 0.67 || 0.353 || ≤12 || 13 to 25 || ≥26
|-
| 0.68 || 0.363 || ≤13 || 14 to 26 || ≥27
|-
| 0.69 || 0.374 || ≤13 || 14 to 27 || ≥28
|}
 
From: College of American Pathologists. [https://www.cap.org/wp-content/uploads/2026/06/Breast.Invasive.Bx_1.3.0.0.REL_CAPCP.pdf] (Page 8), in turn citing: Pathology Reporting of Breast Disease, by National Health Service Cancer Screening Programme and The Royal College of Pathologists</ref><noinclude>
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Latest revision as of 12:33, 14 July 2026

Author:

Mikael Häggström [note 1]

File:Mitosis appearances in breast cancer.jpg
Mitosis appearances in breast cancer

edit
Mitotic figures are counted only at the periphery of the tumor, and counting should begin in the most mitotically active areas, and in at least 10 high-power fields (HPFs). If you know that the area of your high power field is about 0.2mm2, then you may score mitotic count as follows:[1]

  • 1 point: ≤7 mitoses per 10 HPFs
  • 2 points: 8 to 14 mitoses per 10 HPFs
  • 3 points: ≥15 mitoses per 10 HPFs

If you have a significant different HPF area or you are not sure, count 10 HPFs and calculate the number of mitoses per mm2 (Further information: Evaluation#Counts per mm2 ):

  • 1 point: ≤3 mitoses per mm2
  • 2 points: 4 to 7 mitoses per mm2
  • 3 points: ≥7 mitoses per mm2

A table of counts for various HPF sizes is available in notes below.[note 2]

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
  2. ↑
    Table 1. Score categories according to field diameter and mitotic count
    Field diameter (mm) Area (mm²) Number of mitoses per 10 fields corresponding to:
    Score 1 Score 2 Score 3
    0.40 0.125 ≤4 5 to 9 ≥10
    0.41 0.132 ≤4 5 to 9 ≥10
    0.42 0.139 ≤5 6 to 10 ≥11
    0.43 0.145 ≤5 6 to 10 ≥11
    0.44 0.152 ≤5 6 to 11 ≥12
    0.45 0.159 ≤5 6 to 11 ≥12
    0.46 0.166 ≤6 7 to 12 ≥13
    0.47 0.173 ≤6 7 to 12 ≥13
    0.48 0.181 ≤6 7 to 13 ≥14
    0.49 0.189 ≤6 7 to 13 ≥14
    0.50 0.196 ≤7 8 to 14 ≥15
    0.51 0.204 ≤7 8 to 14 ≥15
    0.52 0.212 ≤7 8 to 15 ≥16
    0.53 0.221 ≤8 9 to 16 ≥17
    0.54 0.229 ≤8 9 to 16 ≥17
    0.55 0.238 ≤8 9 to 17 ≥18
    0.56 0.246 ≤8 9 to 17 ≥18
    0.57 0.255 ≤9 10 to 18 ≥19
    0.58 0.264 ≤9 10 to 19 ≥20
    0.59 0.273 ≤9 10 to 19 ≥20
    0.60 0.283 ≤10 11 to 20 ≥21
    0.61 0.292 ≤10 11 to 21 ≥22
    0.62 0.302 ≤11 12 to 22 ≥23
    0.63 0.312 ≤11 12 to 22 ≥23
    0.64 0.322 ≤11 12 to 23 ≥24
    0.65 0.332 ≤12 13 to 24 ≥25
    0.66 0.342 ≤12 13 to 24 ≥25
    0.67 0.353 ≤12 13 to 25 ≥26
    0.68 0.363 ≤13 14 to 26 ≥27
    0.69 0.374 ≤13 14 to 27 ≥28

    From: College of American Pathologists. [1] (Page 8), in turn citing: Pathology Reporting of Breast Disease, by National Health Service Cancer Screening Programme and The Royal College of Pathologists

Main page

References

  1. ↑ . Protocol for the Examination of Resection Specimens from Patients with Invasive Carcinoma of the Breast Version: 4.7.0.1 - Table 1. Score Categories According to Field Diameter and Mitotic Count. College of American Pathologists. Protocol Posting Date: September 2022

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