Borderline tumor: Difference between revisions

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==Gross processing==
==Gross processing==
Depending on presentation:
Depending on presentation:
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==Microscopic evaluation==
==Microscopic evaluation==
[[File:Histopathology of seromucinous borderline tumors.jpg|thumb|300px|'''Seromucinous borderline tumors'''; microscopic pictures showing a variety of cell types. <br>(a) Sometimes mucinous cells with voluminous cytoplasm can mimic goblet cells. Admixed lightly eosinophilic ciliated cells are almost always identifiable. <br>(b) Background of prominent neutrophilic infiltration. Admixture of mucinous cells, eosinophilic cells, and some clear cells, with mild or moderate nuclear atypia and stratifications. <br>(c) Indifferent cells with abundant eosinophilic cytoplasm. <br>(d) Endometrioid type epithelium. <br>(e) Squamous epithelium. <br>(f) Clear cells. Focal hobnail appearance is also seen (right lower corner).<ref>{{cite journal| author=Nagamine M, Mikami Y| title=Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues. | journal= Diagnostics| year= 2020 | volume= 10 | issue= 2 | page=77 | pmid=32023964 | doi=10.3390/diagnostics10020077 | pmc= 7168900| doi-access=free }}<br>- "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref>]]
Exclude other causes of tumor or cyst. {{further|Ovarian tumor|Ovarian cyst}}
Exclude other causes of tumor or cyst. {{further|Ovarian tumor|Ovarian cyst}}
<gallery mode=packed heights=280>
<gallery mode=packed heights=260>
File:Histopathology of ovarian serous borderline tumor.jpg|Typical features of an '''ovarian serous borderline tumor''': Hierarchical branching, exfoliated cell clusters, calcifications, up to moderate atypia, and pseudostratified, crowded epithelium with hobnailing.{{MH}}]]
File:Histopathology of ovarian serous borderline tumor.jpg|Typical features of an '''ovarian serous borderline tumor''': Hierarchical branching, exfoliated cell clusters, calcifications, up to moderate atypia, and pseudostratified, crowded epithelium with hobnailing.{{MH}}
File:Histopathology of seromucinous borderline tumors.jpg|'''Seromucinous borderline tumors'''; microscopic pictures showing a variety of cell types. <br>(a) Sometimes mucinous cells with voluminous cytoplasm can mimic goblet cells. Admixed lightly eosinophilic ciliated cells are almost always identifiable. <br>(b) Background of prominent neutrophilic infiltration. Admixture of mucinous cells, eosinophilic cells, and some clear cells, with mild or moderate nuclear atypia and stratifications. <br>(c) Indifferent cells with abundant eosinophilic cytoplasm. <br>(d) Endometrioid type epithelium. <br>(e) Squamous epithelium. <br>(f) Clear cells. Focal hobnail appearance is also seen (right lower corner).<ref>{{cite journal| author=Nagamine M, Mikami Y| title=Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues. | journal= Diagnostics| year= 2020 | volume= 10 | issue= 2 | page=77 | pmid=32023964 | doi=10.3390/diagnostics10020077 | pmc= 7168900| doi-access=free }}<br>- "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."</ref>
File:Histopathology of ovarian serous borderline tumor with non-invasive invaginations.jpg|Borderline tumors may have '''non-invasive invaginations''' as shown. Otherwise, invasion renders a diagnosis of '''[[ovarian cancer]]'''
</gallery>
</gallery>


Latest revision as of 16:13, 20 April 2022

Author: Mikael Häggström [note 1]

Gross processing

Depending on presentation:

Microscopic evaluation

File:Histopathology of seromucinous borderline tumors.jpg
Seromucinous borderline tumors; microscopic pictures showing a variety of cell types.
(a) Sometimes mucinous cells with voluminous cytoplasm can mimic goblet cells. Admixed lightly eosinophilic ciliated cells are almost always identifiable.
(b) Background of prominent neutrophilic infiltration. Admixture of mucinous cells, eosinophilic cells, and some clear cells, with mild or moderate nuclear atypia and stratifications.
(c) Indifferent cells with abundant eosinophilic cytoplasm.
(d) Endometrioid type epithelium.
(e) Squamous epithelium.
(f) Clear cells. Focal hobnail appearance is also seen (right lower corner).[1]

Exclude other causes of tumor or cyst. Further information: Ovarian tumor and Ovarian cyst

Microscopic report

Include at least:

  • The diagnosis of an ovarian borderline tumor, with subtyping of serous versus mucinous if applicable
  • Size

Example:

Left ovary, oophorectomy:
Ovarian serous borderline tumor (9.1 cm).

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Nagamine M, Mikami Y (2020). "Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues. ". Diagnostics 10 (2): 77. doi:10.3390/diagnostics10020077. PMID 32023964. 
    - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."

Image sources

  1. ↑ Image(s) by: Mikael Häggström, M.D. Public Domain
    - Author info
    - Reusing images
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