Donor kidney biopsy: Difference between revisions

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|author1=[[User:Mikael Häggström|Mikael Häggström]]
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{{Memorization-worthy}} A donor kidney biopsy may come for [[frozen section]]ing.
{{Memorization-worthy}} A donor kidney biopsy may come for [[frozen section]]ing.
 
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==Gross processing==
==Gross processing==
Prepare a separate slide for right versus left kidney if applicable.
Prepare a separate slide for right versus left kidney if applicable.


==Microscopic evaluation==
==Microscopic evaluation==
[[File:Total hyalinization of a glomerulus.jpg|thumb|Glomerulus with global sclerosis.]]
Generally evaluate as per local protocol, which generally includes the following parameters, given individually for right and left kidney:
Generally evaluate as per local protocol, which may include the following, given individually for right and left kidney:
<gallery mode=packed heights=200>
*Total '''number of glomeruli'''.  
File:Total hyalinization of a glomerulus.jpg|- '''Number''' of glomeruli with '''global sclerosis'''<br>- Total '''number of glomeruli'''.<br>- '''Percentage''' of glomeruli with '''global sclerosis''' (number of glomeruli with global sclerosis divided by total number of glomeruli).
*'''Number''' of glomeruli with '''global sclerosis'''
File:Histopathology of tubular atrophy.png|'''Tubular atrophy'''/'''tubular interstitial fibrosis''', as percentage of tubules. Features of tubular atrophy are shown (of which casts is often not present).<ref>{{cite journal| author=Schelling JR| title=Tubular atrophy in the pathogenesis of chronic kidney disease progression. | journal=Pediatr Nephrol | year= 2016 | volume= 31 | issue= 5 | pages= 693-706 | pmid=26208584 | doi=10.1007/s00467-015-3169-4 | pmc=4726480 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26208584  }} </ref>{{MH}}
*'''Percentage''' of glomeruli with '''global sclerosis''' (number of glomeruli with global sclerosis divided by total number of glomeruli).
File:Histopathology of arcuate artery nephrosclerosis, annotated.jpg|thumb|'''Arteriosclerosis''' seen as intimal thickening with an onion skin-like appearance. Arteriosclerosis can be graded as mild, moderate or severe.
*'''Tubular atrophy'''/'''tubular interstitial fibrosis'''
File:Histopathology of renal arteriolar hyalinosis, annotated.jpg|'''Arteriolar hyalinosis''', graded as mild, moderate or severe.
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File:Histopathology of tubular atrophy.png|HFeatures of tubular atrophy.{{MH}}
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Latest revision as of 20:34, 28 November 2022

Author: Mikael Häggström [note 1]
Memorization-worthy:[note 2] A donor kidney biopsy may come for frozen sectioning.

Gross processing

Prepare a separate slide for right versus left kidney if applicable.

Microscopic evaluation

Generally evaluate as per local protocol, which generally includes the following parameters, given individually for right and left kidney:

  • - Number of glomeruli with global sclerosis - Total number of glomeruli. - Percentage of glomeruli with global sclerosis (number of glomeruli with global sclerosis divided by total number of glomeruli).
    - Number of glomeruli with global sclerosis
    - Total number of glomeruli.
    - Percentage of glomeruli with global sclerosis (number of glomeruli with global sclerosis divided by total number of glomeruli).
  • Tubular atrophy/tubular interstitial fibrosis, as percentage of tubules. Features of tubular atrophy are shown (of which casts is often not present).[1][image 1]
    Tubular atrophy/tubular interstitial fibrosis, as percentage of tubules. Features of tubular atrophy are shown (of which casts is often not present).[1][image 1]
  • Arteriosclerosis seen as intimal thickening with an onion skin-like appearance. Arteriosclerosis can be graded as mild, moderate or severe.
    Arteriosclerosis seen as intimal thickening with an onion skin-like appearance. Arteriosclerosis can be graded as mild, moderate or severe.
  • Arteriolar hyalinosis, graded as mild, moderate or severe.
    Arteriolar hyalinosis, graded as mild, moderate or severe.

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
  2. ↑ Further information on what is memorization-worthy or not: Learning pathology

Main page

References

  1. ↑ Schelling JR (2016). "Tubular atrophy in the pathogenesis of chronic kidney disease progression. ". Pediatr Nephrol 31 (5): 693-706. doi:10.1007/s00467-015-3169-4. PMID 26208584. PMC: 4726480. Archived from the original. . 

Image sources

  1. ↑ Image(s) by: Mikael Häggström, M.D. Public Domain
    - Author info
    - Reusing images
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