Myocardial fibrosis: Difference between revisions
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→Microscopic evaluation: Alcian blue stain |
→Microscopic evaluation: +Subepicardial |
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In case of myocardial fibrosis, attempt to distinguish between the following: | In case of myocardial fibrosis, attempt to distinguish between the following: | ||
*'''Interstitial fibrosis''', which is nonspecific,<ref name="ChuteAujla2019">{{cite journal|last1=Chute|first1=Michael|last2=Aujla|first2=Preetinder|last3=Jana|first3=Sayantan|last4=Kassiri|first4=Zamaneh|title=The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis|journal=Journal of Cardiovascular Development and Disease|volume=6|issue=4|year=2019|pages=35|issn=2308-3425|doi=10.3390/jcdd6040035}}</ref> (and may simply reported as such).<ref group="notes">Interstitial fibrosis has been described in congestive heart failure, hypertension, and normal aging. (Chute, 2019)</ref> | *'''Interstitial fibrosis''', which is nonspecific,<ref name="ChuteAujla2019">{{cite journal|last1=Chute|first1=Michael|last2=Aujla|first2=Preetinder|last3=Jana|first3=Sayantan|last4=Kassiri|first4=Zamaneh|title=The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis|journal=Journal of Cardiovascular Development and Disease|volume=6|issue=4|year=2019|pages=35|issn=2308-3425|doi=10.3390/jcdd6040035}}</ref> (and may simply reported as such).<ref group="notes">Interstitial fibrosis has been described in congestive heart failure, hypertension, and normal aging. (Chute, 2019)</ref> | ||
*'''Subepicardial fibrosis''', also unspecific (and may simply be reported as such).<ref group="notes">Subepicardial fibrosis is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy.<br>- {{cite journal|last1=Gräni|first1=Christoph|last2=Eichhorn|first2=Christian|last3=Bière|first3=Loïc|last4=Kaneko|first4=Kyoichi|last5=Murthy|first5=Venkatesh L.|last6=Agarwal|first6=Vikram|last7=Aghayev|first7=Ayaz|last8=Steigner|first8=Michael|last9=Blankstein|first9=Ron|last10=Jerosch-Herold|first10=Michael|last11=Kwong|first11=Raymond Y.|title=Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis|journal=Journal of Cardiovascular Magnetic Resonance|volume=21|issue=1|year=2019|issn=1532-429X|doi=10.1186/s12968-019-0520-0}}<br>- {{cite journal|last1=Bhaskaran|first1=Ashwin|last2=Tung|first2=Roderick|last3=Stevenson|first3=William G.|last4=Kumar|first4=Saurabh|title=Catheter Ablation of VT in Non-Ischaemic Cardiomyopathies: Endocardial, Epicardial and Intramural Approaches|journal=Heart, Lung and Circulation|volume=28|issue=1|year=2019|pages=84–101|issn=14439506|doi=10.1016/j.hlc.2018.10.007}}</ref> | |||
*'''Replacement fibrosis''', which indicates an older infarction.<ref name="ChuteAujla2019"/> | *'''Replacement fibrosis''', which indicates an older infarction.<ref name="ChuteAujla2019"/> | ||
<gallery mode=packed heights=230> | <gallery mode=packed heights=230> | ||
File:Histopathology of interstitial fibrosis in dilated cardiomyopathy.jpg|Healthy myocardium versus interstitial fibrosis in dilated cardiomyopathy. Alcian blue stain. | File:Histopathology of interstitial fibrosis in dilated cardiomyopathy.jpg|Healthy myocardium versus interstitial fibrosis in dilated cardiomyopathy. Alcian blue stain. | ||
File:Subepicardial fibrosis.jpg|Subepicardial fibrosis (epicardium at top). | |||
File:Histopathology of dense fibrous scar replacing myocyte loss in myocardial infarction.jpg|Replacement fibrosis in myocardial infarction, being boundless and dense. | File:Histopathology of dense fibrous scar replacing myocyte loss in myocardial infarction.jpg|Replacement fibrosis in myocardial infarction, being boundless and dense. | ||
</gallery> | </gallery> | ||
Unspecific myocardial fibrosis may simply be reported as such. | Unspecific myocardial fibrosis may simply be reported as such. | ||
{{Bottom}} | {{Bottom}} | ||
Revision as of 08:59, 21 February 2020
Author:
Mikael Häggström [note 1]
Presentations
Microscopic evaluation
In case of myocardial fibrosis, attempt to distinguish between the following:
- Interstitial fibrosis, which is nonspecific,[1] (and may simply reported as such).[notes 1]
- Subepicardial fibrosis, also unspecific (and may simply be reported as such).[notes 2]
- Replacement fibrosis, which indicates an older infarction.[1]
-
Healthy myocardium versus interstitial fibrosis in dilated cardiomyopathy. Alcian blue stain.
-
Subepicardial fibrosis (epicardium at top).
-
Replacement fibrosis in myocardial infarction, being boundless and dense.
Unspecific myocardial fibrosis may simply be reported as such.
Notes
- ↑ Interstitial fibrosis has been described in congestive heart failure, hypertension, and normal aging. (Chute, 2019)
- ↑ Subepicardial fibrosis is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy.
- Gräni, Christoph; Eichhorn, Christian; Bière, Loïc; Kaneko, Kyoichi; Murthy, Venkatesh L.; Agarwal, Vikram; Aghayev, Ayaz; Steigner, Michael; et al. (2019). "Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis ". Journal of Cardiovascular Magnetic Resonance 21 (1). doi:. ISSN 1532-429X.
- Bhaskaran, Ashwin; Tung, Roderick; Stevenson, William G.; Kumar, Saurabh (2019). "Catheter Ablation of VT in Non-Ischaemic Cardiomyopathies: Endocardial, Epicardial and Intramural Approaches ". Heart, Lung and Circulation 28 (1): 84–101. doi:. ISSN 14439506.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Chute, Michael; Aujla, Preetinder; Jana, Sayantan; Kassiri, Zamaneh (2019). "The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis ". Journal of Cardiovascular Development and Disease 6 (4): 35. doi:. ISSN 2308-3425.
Image sources