Fibrocystic breast changes: Difference between revisions
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When unsure, perform immunohistochemistry for '''calponin''': | When unsure, perform immunohistochemistry for '''calponin''': | ||
[[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker{{myoepithelial marker}} (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] | [[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker{{myoepithelial marker note}} (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] | ||
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Revision as of 09:53, 10 February 2022
Author:
Mikael Häggström [note 1]
Presentations
Microscopic examination
Types:
-
Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1]
-
A radial scar of the breast, seen as a fibroelastic stroma and entrapped glands radiating outward.
![Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_sclerosing_adenosis_of_the_breast.jpg){kind=link}
Differential diagnosis
Sclerosing adenosis may look similar to invasive ductal carcinoma (IDC), but IDC will:[1]
- Not be lobular at low power
- Have marked cellular atypia
- Have no myoepithelial cells surrounding ducts.
When unsure, perform immunohistochemistry for calponin:
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
- ↑ For myoepithelial markers, a combination of p63 (higher specificity) with either SMM or calponin (both have higher sensitivity) is generally recommended for breast lesions. D2-40 is useful for highlighting lymphatics for invasion.
Main page
References
- ↑ 1.0 1.1 Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.. Breast - Fibrocystic changes - Sclerosing adenosis. Pathology Outlines. Topic Completed: 1 January 2015. Minor changes: 31 December 2020
Image sources