Pheochromocytoma: Difference between revisions
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[[File:Histopathology of pheochromocytoma.jpg|thumb|300px|Typical features.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma|website=Pathology Outlines|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]] | [[File:Histopathology of pheochromocytoma.jpg|thumb|300px|Typical features.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma|website=Pathology Outlines|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]] | ||
[[File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg|thumb|300px|A pheochromocytoma with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells.]] | [[File:Histopathology of a pheochromocytoma with coagulative necrosis, annotated.jpg|thumb|300px|A pheochromocytoma with coagulative necrosis, displayed at gross pathology (upper left) and light microscopy at low (upper right), medium (lower left) and high magnification (lower right) showing ghost cells.]] | ||
Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells. | Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells. Sustentacular cells may be seen surrounding nests, as rather spindly cells. | ||
===Further workup=== | ===Further workup=== | ||
Latest revision as of 19:03, 1 March 2022
Author:
Mikael Häggström [note 1]
Gross processing
As per Adrenal tumors
Evaluation
Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells. Sustentacular cells may be seen surrounding nests, as rather spindly cells.
Further workup
For a diagnosis of pheochromocytoma, look for any adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures.
Example report
| Right adrenal gland, resection: Adrenal pheochromocytoma (3.0 cm tumor). Surgical margins are negative for neoplasia. (Optionally: Comment: This adrenal pheochromocytoma exhibits no adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures. Nonetheless, metastatic potential is difficult to predict based on histologic parameters.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Katherine A. Lehman, B.S., Debra L. Zynger, M.D.. Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma. Pathology Outlines. Topic Completed: 20 August 2021. Minor changes: 20 August 2021
Image sources