Cervical biopsy: Difference between revisions

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File:Histology of endocervix.jpg|'''Endocervical mucosa''', with mucinous columnar epithelium and mucinous glands. H&E stain
File:Histology of endocervix.jpg|'''Endocervical mucosa''', with mucinous columnar epithelium and mucinous glands. H&E stain
File:Transformation zone types.png|The anatomic level of the transformation zone varies:<ref>International Federation for Cervical Pathology and Colposcopy (IFCPC) classification. References:<br>-{{cite web|url=https://www.rcpa.edu.au/Library/Practising-Pathology/Structured-Pathology-Reporting-of-Cancer/Docs/Transformation_zone|title=Transformation zone (TZ) and cervical excision types|website=[[:en:Royal College of Pathologists of Australasia|Royal College of Pathologists of Australasia]]}}<br>- {{cite journal|last1=Jordan|first1=J.|last2=Arbyn|first2=M.|last3=Martin-Hirsch|first3=P.|last4=Schenck|first4=U.|last5=Baldauf|first5=J-J.|last6=Da Silva|first6=D.|last7=Anttila|first7=A.|last8=Nieminen|first8=P.|last9=Prendiville|first9=W.|title=European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1|journal=Cytopathology|volume=19|issue=6|year=2008|pages=342–354|issn=0956-5507|doi=10.1111/j.1365-2303.2008.00623.x|pmid=19040546|s2cid=16462929|doi-access=free}}</ref><br>Type 1: Completely ectocervical (common under hormonal influence).<br>Type 2: Endocervical component but fully visible (common before puberty).<br>Type 3: Endocervical component, not fully visible (common after menopause).
File:Transformation zone types.png|The anatomic level of the transformation zone varies:<ref>International Federation for Cervical Pathology and Colposcopy (IFCPC) classification. References:<br>-{{cite web|url=https://www.rcpa.edu.au/Library/Practising-Pathology/Structured-Pathology-Reporting-of-Cancer/Docs/Transformation_zone|title=Transformation zone (TZ) and cervical excision types|website=[[:en:Royal College of Pathologists of Australasia|Royal College of Pathologists of Australasia]]}}<br>- {{cite journal|last1=Jordan|first1=J.|last2=Arbyn|first2=M.|last3=Martin-Hirsch|first3=P.|last4=Schenck|first4=U.|last5=Baldauf|first5=J-J.|last6=Da Silva|first6=D.|last7=Anttila|first7=A.|last8=Nieminen|first8=P.|last9=Prendiville|first9=W.|title=European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1|journal=Cytopathology|volume=19|issue=6|year=2008|pages=342–354|issn=0956-5507|doi=10.1111/j.1365-2303.2008.00623.x|pmid=19040546|s2cid=16462929|doi-access=free}}</ref><br>Type 1: Completely ectocervical (common under hormonal influence).<br>Type 2: Endocervical component but fully visible (common before puberty).<br>Type 3: Endocervical component, not fully visible (common after menopause).
File:Histology of normal simple columnar epithelium of the endometrium.jpg|If you see fragments of non-mucinous '''simple columnar''' epithelium, it is likely endometrial, so evaluate it like an '''[[endometrial curetting]]'''.
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Revision as of 13:26, 9 April 2022

Author: Mikael Häggström [note 1]
This article includes endocervical curettage (ECC).

Comprehensiveness

On this resource, the following formatting is used for comprehensiveness:

  • Minimal depth
  • (Moderate depth)
  • ((Comprehensive))

Fixation

Generally 10% neutral buffered formalin.

  See also: General notes on fixation


Gross processing

Example report:

(Optionally: A. Container is labeled - __. The specimen is received in formalin and consists of ) 1 fragment(s) of pink-tan tissue with a vaguely recognizable mucosal surface. The tissue measures __ cm. (The surgical margin is inked black. The specimen is bisected and entirely submitted for microscopic examination in one cassette.)

Microscopic evaluation

Anatomic/Histologic location

Describe mucosa as squamous (or ectocervical), endocervical (generally mucinous and glandular) or transformation zone mucosa.

Pathologies

edit
Look for cervical dysplasia. It is mainly seen as nuclei with hyperchromasia, coarse chromatin and irregular contours.[2]

Further information: Cervical dysplasia

Other common findings:

Example report

Endocervix, curettings:
Fragments of squamous and endocervical glandular epithelium without significant histopathologic changes.
Negative for dysplasia.

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ International Federation for Cervical Pathology and Colposcopy (IFCPC) classification. References:
    -. Transformation zone (TZ) and cervical excision types. Royal College of Pathologists of Australasia.
    - Jordan, J.; Arbyn, M.; Martin-Hirsch, P.; Schenck, U.; Baldauf, J-J.; Da Silva, D.; Anttila, A.; Nieminen, P.; et al. (2008). "European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1 ". Cytopathology 19 (6): 342–354. doi:10.1111/j.1365-2303.2008.00623.x. ISSN 0956-5507. PMID 19040546. 
  2. ↑ Khaled J. Alkhateeb, M.B.B.S., Ziyan T. Salih, M.D.. HSIL / CIN II / CIN III. PathologyOutlines. Topic Completed: 29 March 2021. Minor changes: 9 February 2022
  3. ↑ Source image by Ed Uthman from Houston, TX, USA. Creative Commons Attribution 2.0 Generic (CC BY 2.0) license

Image sources
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