Soft tissue tumor: Difference between revisions
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[[File:Histopathology of solitary fibrous tumor.png|thumb|A '''solitary fibrous tumor''', an example of spindle cell tumor.]] | [[File:Histopathology of solitary fibrous tumor.png|thumb|A '''solitary fibrous tumor''', an example of spindle cell tumor.]] | ||
In case of '''spindle cell tumors''' (having elongated nuclei), the following features may help to roughly classify the tumor: | In case of '''spindle cell tumors''' (having elongated nuclei), the following features may help to roughly classify the tumor: | ||
*Pointed on both ends: True fibroblastic tumors | *Pointed on both ends: '''True fibroblastic tumors''' | ||
*Pointed on one end and blunted on the other ("bullet-shaped"): Neural | *Pointed on one end and blunted on the other ("bullet-shaped"): '''Neural'''/'''nerve sheath''' tumors (see section below) | ||
*Blunted on both ends ("cigar-shaped"): '''[[Smooth muscle tumor]]''' | *Blunted on both ends ("cigar-shaped"): '''[[Smooth muscle tumor]]''' | ||
*Triangular: Myofibroblastic | *Triangular: Myofibroblastic | ||
In uncertain cases, the following [[immunohistochemistry]] markers are usually helpful: | In uncertain cases, the following [[immunohistochemistry]] markers are usually helpful: | ||
*'''CD34''', indicating a solitary fibrous tumor | *'''CD34''', indicating a solitary fibrous tumor | ||
*'''S100''', indicating a neural tumor | *'''S100''', indicating a neural or nerve sheath tumor (see section below) | ||
*'''Desmin''', indicating a muscular tumor (skeletal muscle or '''[[Smooth muscle tumor]]''') | *'''Desmin''', indicating a muscular tumor (skeletal muscle or '''[[Smooth muscle tumor]]''') | ||
*'''Beta catenin''', indicating fibromatosis | *'''Beta catenin''', indicating fibromatosis | ||
===Neural or nerve sheath tumors=== | |||
<gallery mode=packed heights=210px> | |||
File:Schwannoma with Antoni A and Antoni B areas.jpg|'''Schwannoma''', characterized by cellular Antoni A areas (top) and a loose paucicellular Antoni B areas (bottom). | |||
File:Antoni A area of schwannoma with Verocay bodies - annotated.png|'''Schwannoma''' is also characterized by Verocay bodies (one encircled), which are stripes of anuclear zones, separated by cellular palisades. | |||
File:Histopathology of neurofibroma.jpg|'''Neurofibroma''': A spindle cell lesion composed of slender fibroblast-like cells with storiform pattern and very low amount of stroma. | |||
</gallery> | |||
{{Further|Evaluation of suspected malignancies}} | {{Further|Evaluation of suspected malignancies}} | ||
{{Bottom}} | {{Bottom}} | ||
Revision as of 17:33, 29 September 2022
Author:
Mikael Häggström [note 1]
Gross processing
-
If it appears fatty, gross and evaluate as a lipomatous tumor.
Generally sample one slice per centimeter.
Evaluation
In case of spindle cell tumors (having elongated nuclei), the following features may help to roughly classify the tumor:
- Pointed on both ends: True fibroblastic tumors
- Pointed on one end and blunted on the other ("bullet-shaped"): Neural/nerve sheath tumors (see section below)
- Blunted on both ends ("cigar-shaped"): Smooth muscle tumor
- Triangular: Myofibroblastic
In uncertain cases, the following immunohistochemistry markers are usually helpful:
- CD34, indicating a solitary fibrous tumor
- S100, indicating a neural or nerve sheath tumor (see section below)
- Desmin, indicating a muscular tumor (skeletal muscle or Smooth muscle tumor)
- Beta catenin, indicating fibromatosis
Neural or nerve sheath tumors
-
Schwannoma, characterized by cellular Antoni A areas (top) and a loose paucicellular Antoni B areas (bottom).
-
Schwannoma is also characterized by Verocay bodies (one encircled), which are stripes of anuclear zones, separated by cellular palisades.
-
Neurofibroma: A spindle cell lesion composed of slender fibroblast-like cells with storiform pattern and very low amount of stroma.
Further information: Evaluation of suspected malignancies
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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References
Image sources