Granulomatous skin inflammation: Difference between revisions
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File:Touton giant cell (annotated).jpg|Appearance: A '''Touton giant cell''' contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.<ref>{{cite book | last = Grant-Kels | first = Jane | title = Color Atlas of Dermatopathology | publisher = Informa Healthcare | location = City | year = 2007 | isbn = 978-0-8493-3794-9 | pages = 107, 119 }}</ref><ref>{{cite journal |last1=Carmen Gómez-Mateo |first1=Maria |last2=Monteagudo |first2=Carlos |date=2013 |title=Nonepithelial skin tumors with multinucleated giant cells |url=http://www.semdiagpath.com/article/S0740-2570(12)00009-3/fulltext |journal=Seminars in Diagnostic Pathology |volume=30 |issue=1 |pages=58–72 |pmid=23327730 |doi=10.1053/j.semdp.2012.01.004}}</ref> The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.<ref>{{cite journal |last1=Sequeira |first1=Fiona |last2=Gandhi |first2=Suneil |date=2012 |title=Named cells in dermatology |url=http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=207;epage=216;aulast=Sequeira |journal=Indian Journal of Dermatology, Venereology and Leprology |volume=78 |issue=2 |pages=207–16 |doi=10.4103/0378-6323.93650 |pmid=22421663}}</ref> | File:Touton giant cell (annotated).jpg|Appearance: A '''Touton giant cell''' contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.<ref>{{cite book | last = Grant-Kels | first = Jane | title = Color Atlas of Dermatopathology | publisher = Informa Healthcare | location = City | year = 2007 | isbn = 978-0-8493-3794-9 | pages = 107, 119 }}</ref><ref>{{cite journal |last1=Carmen Gómez-Mateo |first1=Maria |last2=Monteagudo |first2=Carlos |date=2013 |title=Nonepithelial skin tumors with multinucleated giant cells |url=http://www.semdiagpath.com/article/S0740-2570(12)00009-3/fulltext |journal=Seminars in Diagnostic Pathology |volume=30 |issue=1 |pages=58–72 |pmid=23327730 |doi=10.1053/j.semdp.2012.01.004}}</ref> The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.<ref>{{cite journal |last1=Sequeira |first1=Fiona |last2=Gandhi |first2=Suneil |date=2012 |title=Named cells in dermatology |url=http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=207;epage=216;aulast=Sequeira |journal=Indian Journal of Dermatology, Venereology and Leprology |volume=78 |issue=2 |pages=207–16 |doi=10.4103/0378-6323.93650 |pmid=22421663}}</ref> | ||
File:Histopathology of granulomatous folliculitis.jpg|thumb|Relation: '''Folliculitis''' with multinucleated giant cells surrounding a hair follicle. | File:Histopathology of granulomatous folliculitis.jpg|thumb|Relation: '''Folliculitis''' with multinucleated giant cells surrounding a hair follicle. | ||
File:Histopathology of granulomatous inflammation by a ruptured inclusion cyst.jpg|Granulomatious inflammation following an epidermal inclusion '''cyst rupture''', with giant cells surrounding keratin flakes. | |||
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Revision as of 14:03, 29 July 2020
Author:
Mikael Häggström [note 1]
- Look for foreign bodies, conferring a diagnosis of foreign body granuloma.
- Look for any specific appearance of the giant cells.
- Look for relation to adnexae or other particular structures.
-
Foreign body: Suture granuloma, with multinucleated giant cells surrounding (grey) suture material.
-
Relation: Folliculitis with multinucleated giant cells surrounding a hair follicle.
-
Granulomatious inflammation following an epidermal inclusion cyst rupture, with giant cells surrounding keratin flakes.
![Appearance: A Touton giant cell contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.[1][2] The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.[3]](/index.php?title=Special:Upload&wpDestFile=Touton_giant_cell_(annotated).jpg){kind=link}
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Grant-Kels, Jane (2007). Color Atlas of Dermatopathology . City: Informa Healthcare. pp. 107, 119. ISBN 978-0-8493-3794-9.
- ↑ Carmen Gómez-Mateo, Maria; Monteagudo, Carlos (2013). "Nonepithelial skin tumors with multinucleated giant cells ". Seminars in Diagnostic Pathology 30 (1): 58–72. doi:. PMID 23327730. Archived from the original. .
- ↑ Sequeira, Fiona; Gandhi, Suneil (2012). "Named cells in dermatology ". Indian Journal of Dermatology, Venereology and Leprology 78 (2): 207–16. doi:. PMID 22421663. Archived from the original. .
Image sources