Pheochromocytoma: Difference between revisions

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==Evaluation==
==Evaluation==
Microscopy typically shows:<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma|website=Pathology Outlines|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>
[[File:Histopathology of pheochromocytoma.jpg|thumb|300px|Typical features.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/adrenalpheochromocytoma.html|title=Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma|website=Pathology Outlines|author=Katherine A. Lehman, B.S., Debra L. Zynger, M.D.}} Topic Completed: 20 August 2021. Minor changes: 20 August 2021</ref>]]
*Architecture of nested (zellballen), trabecular or solid arrangement of tumor cells
Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells.
*Tumor cells being large, polygonal, uniform or extensively vacuolated
*Cytoplasm being abundant fine, granular and red-purple


===Further workup===
===Further workup===

Revision as of 18:55, 1 March 2022

Author: Mikael Häggström [note 1]

Gross processing

As per Adrenal tumors

Evaluation

File:Histopathology of pheochromocytoma.jpg
Typical features.[1]

Architecture can be nested (zellballen), trabecular or solid arrangement of tumor cells.

Further workup

For a diagnosis of pheochromocytoma, look for any adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures.

Example report

Right adrenal gland, resection:
Adrenal pheochromocytoma (3.0 cm tumor).
Surgical margins are negative for neoplasia.

(Optionally: Comment: This adrenal pheochromocytoma exhibits no adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures. Nonetheless, metastatic potential is difficult to predict based on histologic parameters.)

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. Katherine A. Lehman, B.S., Debra L. Zynger, M.D.. Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma. Pathology Outlines. Topic Completed: 20 August 2021. Minor changes: 20 August 2021

Image sources