Duodenum: Difference between revisions

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===Others===
===Others===
<gallery mode=packed heights=210>
<gallery mode=packed heights=210>
File:Histopathology of duodenal intra-epithelial lymphocytes.jpg|'''Intra-epithelial lymphocytes''' (IELs) is the main finding in '''celiac disease''' (even in earliest stage)<ref>{{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}</ref>.{{Image source-begin}} {{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}<br>- [https://www.researchgate.net/figure/Photomicrograph-showing-increased-intraepithelial-lymphocytes-H-E-x-200cb_fig3_236066468 Figure 2- available via license: Creative Commons Attribution 2.0 Generic] license.{{Image source-end}}<br>25 - 29 IEL/100 enterocytes is considered borderline.<ref name=pathologyoutlinesceliac>{{cite web|url=https://www.pathologyoutlines.com/topic/smallbowelceliacsprue.html|title=Small intestine & ampulla. Malabsorption. Celiac sprue|author=Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.|website=Pathology Outlines|accessdate=2022-04-04}}</ref><br> > 30 IEL/100 enterocytes represents a pathological lymphocytosis.<ref name=pathologyoutlinesceliac/>
File:Histopathology of duodenal intra-epithelial lymphocytes.jpg|'''Intra-epithelial lymphocytes''' (IELs) is the main finding in '''celiac disease''' (even in earliest stage)<ref>{{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}</ref>.<ref group=images>{{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}<br>- [https://www.researchgate.net/figure/Photomicrograph-showing-increased-intraepithelial-lymphocytes-H-E-x-200cb_fig3_236066468 Figure 2- available via license: Creative Commons Attribution 2.0 Generic] license.</ref><br>25 - 29 IEL/100 enterocytes is considered borderline.<ref name=pathologyoutlinesceliac>{{cite web|url=https://www.pathologyoutlines.com/topic/smallbowelceliacsprue.html|title=Small intestine & ampulla. Malabsorption. Celiac sprue|author=Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.|website=Pathology Outlines|accessdate=2022-04-04}}</ref><br> > 30 IEL/100 enterocytes represents a pathological lymphocytosis.<ref name=pathologyoutlinesceliac/>
File:Histopathology of leiomyoma of the ileocecal valve.jpg|'''Tumors''' (leiomyoma pictured): evaluate as per '''[[intestine with tumor]]'''
File:Histopathology of leiomyoma of the ileocecal valve.jpg|'''Tumors''' (leiomyoma pictured): evaluate as per '''[[intestine with tumor]]'''
</gallery>
</gallery>

Revision as of 17:58, 22 April 2022

Author: Mikael Häggström [note 1]

Endoscopic biopsies   edit
Mostly:

Common requests

Microscopic examination

Generally look for:

  • Signs of peptic duodenitis
  • Intra-epithelial lymphocytes
  • Tumors

Peptic duodenitis

Peptic duodenitis typically showing the following:[1]

Others

Report

Example in a normal case:

(Duodenum, biopsy:) Duodenal mucosa without significant histopathologic changes. (Negative for celiac disease.)

Example in (chronic) peptic duodenitis:

(Small bowel, biopsy:) Small intestinal mucosa with histologic changes consistent with chronic peptic duodenitis. (Negative for celiac disease.)

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Hasan Samra, M.D., Mohamed Mostafa, M.D.. Small intestine & ampulla - Inflammatory disorders - Peptic duodenitis. Pathology Outlines. Topic Completed: 13 April 2020. Minor changes: 13 April 2020
  2. ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') ". Gastroenterology 102 (1): 330–54. 1992. doi:10.1016/0016-5085(92)91819-p. PMID 1727768. 
  3. ↑ 3.0 3.1 Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.. Small intestine & ampulla. Malabsorption. Celiac sprue. Pathology Outlines. Retrieved on 2022-04-04.

Image sources

  1. ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') ". Gastroenterology 102 (1): 330–54. 1992. doi:10.1016/0016-5085(92)91819-p. PMID 1727768. 
    - Figure 2- available via license: Creative Commons Attribution 2.0 Generic license.
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