Duodenum: Difference between revisions
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===Others=== | ===Others=== | ||
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File:Histopathology of duodenal intra-epithelial lymphocytes.jpg|'''Intra-epithelial lymphocytes''' (IELs) is the main finding in '''celiac disease''' (even in earliest stage)<ref>{{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}</ref> | File:Histopathology of duodenal intra-epithelial lymphocytes.jpg|'''Intra-epithelial lymphocytes''' (IELs) is the main finding in '''celiac disease''' (even in earliest stage)<ref>{{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}</ref>,<ref group=images>{{cite journal | vauthors = Marsh MN |title=Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') |journal=Gastroenterology |volume=102 |issue=1 |pages=330–54 |year=1992 |pmid=1727768 |doi=10.1016/0016-5085(92)91819-p}}<br>- [https://www.researchgate.net/figure/Photomicrograph-showing-increased-intraepithelial-lymphocytes-H-E-x-200cb_fig3_236066468 Figure 2- available via license: Creative Commons Attribution 2.0 Generic] license.</ref> and is best evaluated at tips of villi<ref name="pmid15280404">{{cite journal| author=Biagi F, Luinetti O, Campanella J, Klersy C, Zambelli C, Villanacci V | display-authors=etal| title=Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? | journal=J Clin Pathol | year= 2004 | volume= 57 | issue= 8 | pages= 835-9 | pmid=15280404 | doi=10.1136/jcp.2003.013607 | pmc=1770380 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15280404 }} </ref>.<br>25 - 29 IEL/100 enterocytes is considered borderline.<ref name=pathologyoutlinesceliac>{{cite web|url=https://www.pathologyoutlines.com/topic/smallbowelceliacsprue.html|title=Small intestine & ampulla. Malabsorption. Celiac sprue|author=Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.|website=Pathology Outlines|accessdate=2022-04-04}}</ref><br> > 30 IEL/100 enterocytes represents a pathological lymphocytosis.<ref name=pathologyoutlinesceliac/> | ||
File:Histopathology of leiomyoma of the ileocecal valve.jpg|'''Tumors''' (leiomyoma pictured): evaluate as per '''[[intestine with tumor]]''' | File:Histopathology of leiomyoma of the ileocecal valve.jpg|'''Tumors''' (leiomyoma pictured): evaluate as per '''[[intestine with tumor]]''' | ||
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Revision as of 17:26, 1 May 2022
Author:
Mikael Häggström [note 1]
| Mostly: |
Common requests
Microscopic examination
Generally look for:
- Signs of peptic duodenitis
- Intra-epithelial lymphocytes
- Tumors
Peptic duodenitis
Peptic duodenitis typically showing the following:[1]
-
Brunner gland hyperplasia shows as Brunner glands above the muscularis mucosae.
Others
-
Intra-epithelial lymphocytes (IELs) is the main finding in celiac disease (even in earliest stage)[2],[images 1] and is best evaluated at tips of villi[3].
25 - 29 IEL/100 enterocytes is considered borderline.[4]
> 30 IEL/100 enterocytes represents a pathological lymphocytosis.[4] -
Tumors (leiomyoma pictured): evaluate as per intestine with tumor
![Intra-epithelial lymphocytes (IELs) is the main finding in celiac disease (even in earliest stage)[2],[images 1] and is best evaluated at tips of villi[3]. 25 - 29 IEL/100 enterocytes is considered borderline.[4] > 30 IEL/100 enterocytes represents a pathological lymphocytosis.[4]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_duodenal_intra-epithelial_lymphocytes.jpg){kind=link}
Report
Example in a normal case:
| (Duodenum, biopsy:) Duodenal mucosa without significant histopathologic changes. (Negative for celiac disease.) |
Example in (chronic) peptic duodenitis:
| (Small bowel, biopsy:) Small intestinal mucosa with histologic changes consistent with chronic peptic duodenitis. (Negative for celiac disease.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Hasan Samra, M.D., Mohamed Mostafa, M.D.. Small intestine & ampulla - Inflammatory disorders - Peptic duodenitis. Pathology Outlines. Topic Completed: 13 April 2020. Minor changes: 13 April 2020
- ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') ". Gastroenterology 102 (1): 330–54. 1992. doi:. PMID 1727768.
- ↑ Biagi F, Luinetti O, Campanella J, Klersy C, Zambelli C, Villanacci V (2004). "Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? ". J Clin Pathol 57 (8): 835-9. doi:. PMID 15280404. PMC: 1770380. Archived from the original. .
- ↑ 4.0 4.1 Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.. Small intestine & ampulla. Malabsorption. Celiac sprue. Pathology Outlines. Retrieved on 2022-04-04.
Image sources
- ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')
". Gastroenterology 102 (1): 330–54. 1992. doi:. PMID 1727768.
- Figure 2- available via license: Creative Commons Attribution 2.0 Generic license.