Meningioma: Difference between revisions
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{{further|Brain/meningeal tumor}} | {{further|Brain/meningeal tumor}} | ||
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==Microscopic evaluation== | ==Microscopic evaluation== | ||
[[File:Histopathology of meningioma.png|thumb|Histopathology of a typical WHO grade 1 meningioma, | [[File:Histopathology of meningioma.png|thumb|Histopathology of a typical WHO grade 1 meningioma, H&E stain. It is of the meningothelial histologic type, which is the most common meningioma type. It shows its typical findings:<br>- A woven architectural pattern<br>- Psammoma bodies (spheroid calcifications)<br>- Syncytial cells (having indistinct cell membranes) with eosinophilic (pink) cytoplasms<br>- Round uniform nuclei<br>- Whorls (concentric cell arrangements)<ref>Image by Mikael Häggström, MD. Reference for typical findings: {{cite web|url=https://www.pathologyoutlines.com/topic/cnstumormeningiomageneral.html|title=Meningioma|website=Pathology Outlines|author=Chunyu Cai, M.D., Ph.D.}} Last author update: 10 November 2021}}</ref>]] | ||
Look for the signs of both typical meningioma and main histological variants. On frozen sections, mention the presence of atypia/high-grade cells. | Look for the signs of both typical meningioma and main histological variants. On frozen sections, mention the presence of atypia/high-grade cells. | ||
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Latest revision as of 15:56, 11 January 2024
Author:
Mikael Häggström [note 1]
Gross processing
Further information: Brain/meningeal tumor
Microscopic evaluation
- A woven architectural pattern
- Psammoma bodies (spheroid calcifications)
- Syncytial cells (having indistinct cell membranes) with eosinophilic (pink) cytoplasms
- Round uniform nuclei
- Whorls (concentric cell arrangements)[1]
Look for the signs of both typical meningioma and main histological variants. On frozen sections, mention the presence of atypia/high-grade cells.
![Histologic variants of meningioma, H&E stain[2]](/File:Histologic_variants_of_meningioma.png)
![Meningioma, low-grade and high-grade. H&E stain.[3]](/File:Low-grade_and_high-grade_meningioma.png)
On permanent sections, classify by WHO grade:
| WHO Grade I | WHO Grade II | WHO Grade III |
|---|---|---|
| Benign | Atypical | Malignant |
|
|
|
Reporting
Example frozen section report:
| A. Right frontal tumor: -Meningioma. Negative for atypia. |
Example permanent section report:
| A. Right frontal tumor: -Meningioma, WHO grade 1. |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Image by Mikael Häggström, MD. Reference for typical findings: Chunyu Cai, M.D., Ph.D.. Meningioma. Pathology Outlines. Last author update: 10 November 2021}}
- ↑ Brabec J, Friedjungová M, Vašata D, Englund E, Bengzon J, Knutsson L (2023). "Meningioma microstructure assessed by diffusion MRI: An investigation of the source of mean diffusivity and fractional anisotropy by quantitative histology.
". Neuroimage Clin 37: 103365. doi:. PMID 36898293. PMC: 10020119. Archived from the original. .
- "This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)" - ↑ Wu C, Zhong J, Lin L, Chen Y, Xue Y, Shi P (2022). "Segmentation of HE-stained meningioma pathological images based on pseudo-labels.
". PLoS One 17 (2): e0263006. doi:. PMID 35120175. PMC: 8815980. Archived from the original. .
- Creative Commons Attribution 4.0 International license - ↑ Jeffrey I. Traylor, MD and John S. Kuo, MD, PhD, FAANS.. Meningiomas. American Association of Neurological Surgeons. Retrieved on 2024-01-11.
Image sources