Autopsy of myocardial infarction: Difference between revisions
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[[File:Histological features of myocardial infarction at different stages.jpg|thumb|400px|Histological features of MI at different stages, without reperfusion; <br>(a) myofiber waviness <br>(b) interstitial oedema<br>(c) hypereosinophilia and coagulative necrosis of cardiomyocytes <br>(d) heavy granulocyte infiltration with karyorrhexis <br>(e) macrophages and lymphocyte infiltration with early removal of necrotic debris <br>(f) granulation tissue with formation of microvessels <br>(g) fibroblast proliferation and early collagen deposition <br>(h) dense fibrous scar replacing myocyte loss <br>All sections are stained with haematoxylin and eosin.]] | [[File:Histological features of myocardial infarction at different stages.jpg|thumb|400px|Histological features of MI at different stages, without reperfusion; <br>(a) myofiber waviness <br>(b) interstitial oedema<br>(c) hypereosinophilia and coagulative necrosis of cardiomyocytes <br>(d) heavy granulocyte infiltration with karyorrhexis <br>(e) macrophages and lymphocyte infiltration with early removal of necrotic debris <br>(f) granulation tissue with formation of microvessels <br>(g) fibroblast proliferation and early collagen deposition <br>(h) dense fibrous scar replacing myocyte loss <br>All sections are stained with haematoxylin and eosin.<ref name="MichaudBasso2019"/>]] | ||
Look for areas of fibrosis or hemorrhage. Sample tissue from suspected areas. | Look for areas of fibrosis or hemorrhage. Sample tissue from suspected areas. | ||
{{Bottom}} | {{Bottom}} | ||
Revision as of 10:33, 19 December 2019
Author:
Mikael Häggström [note 1]
Autopsy
Comprehensiveness
Factors supporting a relatively more comprehensive autopsy and/or report, particularly in the inclusion of negated findings:
- Lack of explanation from existing evidence. On the other hand, for example, upon finding an obvious aortic rupture, the rest of the autopsy is less relevant and may be relatively short.
- Double-reading: If your report is likely to undergo double reading by another pathologist before sign-out, it needs to be more detailed, because the doctor who will do the double-reading then knows that you have looked at those locations.
- Highly suspected locations, such as given from the referral.
On this resource, the following formatting is used for comprehensiveness:
- Minimal depth
- (Moderate depth)
- ((Comprehensive))
Coronary arteries
Make longitudinal (or transverse cuts at 3 mm intervals[1]) through:
- The right coronary artery.
- (The right marginal artery)
- The left coronary and circumflex artery.
- The left anterior descending artery.
- (The left marginal artery)
- (The left diagonal branch)
- Any vessel grafts to the heart
Estimate the percentage of any significant stenosis or occlusion.
-
Plaque at different percentages of atherosclerotic stenosis.[1]
![Plaque at different percentages of atherosclerotic stenosis.[1]](/index.php?title=Special:Upload&wpDestFile=Plaque_at_different_degrees_of_atherosclerotic_stenosis.jpg){kind=link}
The presence of a totally occlusive thrombotic mass confers a diagnosis of likely sudden cardiac death death even in the absence of microscopically visible necrosis.[1]
Myocardium
(a) myofiber waviness
(b) interstitial oedema
(c) hypereosinophilia and coagulative necrosis of cardiomyocytes
(d) heavy granulocyte infiltration with karyorrhexis
(e) macrophages and lymphocyte infiltration with early removal of necrotic debris
(f) granulation tissue with formation of microvessels
(g) fibroblast proliferation and early collagen deposition
(h) dense fibrous scar replacing myocyte loss
All sections are stained with haematoxylin and eosin.[1]
Look for areas of fibrosis or hemorrhage. Sample tissue from suspected areas.
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 1.2 1.3 Michaud, Katarzyna; Basso, Cristina; d’Amati, Giulia; Giordano, Carla; Kholová, Ivana; Preston, Stephen D.; Rizzo, Stefania; Sabatasso, Sara; et al. (2019). "Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification
". Virchows Archiv. doi:. ISSN 0945-6317.
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
Image sources