Kidney autopsy: Difference between revisions
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{{Fixation - general notes}} | {{Fixation - general notes}} | ||
==Microscopic evaluation== | ==Microscopic evaluation== | ||
The main | The main findings to look for:<ref name="PerroneChang2017">{{cite journal|last1=Perrone|first1=Marie E|last2=Chang|first2=Anthony|last3=Henriksen|first3=Kammi J|title=Medical renal diseases are frequent but often unrecognized in adult autopsies|journal=Modern Pathology|volume=31|issue=2|year=2017|pages=365–373|issn=0893-3952|doi=10.1038/modpathol.2017.122}}</ref> | ||
*Glomerular findings | *Glomerular findings | ||
:*Diffuse and/or nodular mesangial sclerosis | :*Diffuse and/or nodular mesangial sclerosis | ||
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</gallery> | </gallery> | ||
==Report== | |||
*Findings and if they are consistent with a known diagnosis. | |||
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Revision as of 12:32, 23 December 2019
Author:
Mikael Häggström [note 1]
Basic autopsy cutting
In non-forensic autopsy, cut the kidneys in the coronal planes.
Fixation
Generally 10% neutral buffered formalin.
See also: General notes on fixation
Microscopic evaluation
The main findings to look for:[1]
- Glomerular findings
- Diffuse and/or nodular mesangial sclerosis
- Mesangial hypercellularity (which has been defined as more than 3 cell nuclei per peripheral mesangial area on a 4-μm thick tissue section)
- Endocapillary hypercellularity
- Glomerular basement membrane thickening and/or duplication
- Thrombi
- Tubulointerstitial findings
- Interstitial inflammation
- Cytologic atypia in the tubular epithelial cells
- Atypical or pigmented casts
- Crystals.
- Vascular findings
- Vasculitis
- Thrombi
- Mural deposition of amorphous material
Alterations in glomerular matrix and/or cellularity
The most common cause is diabetic nephropathy, and typically presents as glomerular enlargement, mesangial sclerosis basement membrane thickening and and arteriolar hyalinosis.[1]
Other
-
Thrombi (arrows) and glomerular crescent formation (dotted enclosure, in rapidly progressive glomerulonephritis, in this case due to SLE).
-
Distal tubular casts (in addition to interstitial inflammation and fibrosis in myeloma cast nephropathy).
-
Histopathology of vasculitis (in systemic sclerosis): fibromuscular intimal proliferation and adventitial fibrosis
Report
- Findings and if they are consistent with a known diagnosis.
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
Image sources