Template:Cervical dysplasia

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Dysplasia is mainly seen as nuclei with hyperchromasia, coarse chromatin and irregular contours.[1]

Cervical intraepithelial neoplasia edit
Histology Grade Corresponding Cytology Description Image
CIN 1 (Grade I) Low-grade squamous intraepithelial lesion (LSIL)
  • Mild epithelial dysplasia
  • Confined to the basal 1/3 of the epithelium
 File:LSIL (CIN 1), Cervical Biopsy (3776284166).jpg
CIN 2/3 High-grade squamous intraepithelial lesion (HSIL)[notes 1]
  • Represents a mix of low and high-grade lesions not easily differentiated by histology
CIN 2 (Grade II)[notes 2]
  • Moderate dysplasia confined to the basal 2/3 of the epithelium
CIN 3 (Grade III)[notes 3]
  • Severe dysplasia with undifferentiated neoplastic cells that span more than 2/3 of the epithelium
  • May involve the full thickness
  • May also be referred to as cervical carcinoma in situ
 File:Histopathology of CIN 3.jpg

Notes

  1. ↑ HSIL+ encompasses HSIL, AGC, and cancer
  2. ↑ CIN 2+ encompasses CIN 2, CIN 3, adenocarcinoma in situ (AIS), and cancer
  3. ↑ CIN 3+ encompasses CIN 3, AIS, and cancer


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References

  1. ↑ Khaled J. Alkhateeb, M.B.B.S., Ziyan T. Salih, M.D.. HSIL / CIN II / CIN III. PathologyOutlines. Topic Completed: 29 March 2021. Minor changes: 9 February 2022
  2. ↑ Source image by Ed Uthman from Houston, TX, USA. Creative Commons Attribution 2.0 Generic (CC BY 2.0) license
  3. ↑ Nagi, Chandandeep S.; Schlosshauer, Peter W. (2006). "Endocervical glandular involvement is associated with high-grade SIL ". Gynecologic Oncology 102 (2): 240–243. doi:10.1016/j.ygyno.2005.12.029. ISSN 00908258. 

Image sources


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