Fibroepithelial tumor
Author:
Mikael Häggström [note 1]
Gross examination
As per:
or mastectomy.
Microscopic evaluation
Characteristics
Biphasic proliferation of both stromal and epithelial components, arranged into either a pericanalicular pattern (stromal proliferation around epithelial structures), or an intracanalicular pattern (stromal proliferation compressing the epithelial structures into clefts). Fibroadenomas characteristically display hypovascular stroma compared to malignant tumors.[1]Cite error: Closing </ref> missing for <ref> tag Furthermore, the epithelial proliferation appears in a single terminal ductal unit and has duct-like spaces surrounded by a fibroblastic stroma. The basement membrane is intact.[2]
Further workup
Exclude breast cancer, which may be present in a fibroadenoma:[3]
Breast cancer types
| Cancer type | Histopathology | Image |
|---|---|---|
| Invasive ductal carcinoma (IDC) | Carcinomatous cells are seen below the basement membrane of lactiferous ducts. Otherwise, there are no specific histologic characteristics, essentially making it a diagnosis of exclusion.[4] | 
|
| Ductal carcinoma in situ (DCIS) | Malignant epithelial cells confined to the ductal system of the breast, without invasion through the basement membrane.[5] | 
|
| Invasive lobular carcinoma (ILC) | The "classic" pattern is round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a targetoid pattern. | File:Classic Invasive Lobular Carcinoma of the Breast (6813147194).jpg |
| Lobular carcinoma in situ (LCIS) |
Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[6] |
File:Histopathology of lobular carcinoma in situ.jpg |
| Mucinous carcinoma | Extracellular mucin areas around tumor cells. | File:Histopathology of mucinous invasive ductal carcinoma of the breast.jpg |
| Medullary carcinoma | Seemingly fused tumor cells (syncytial pattern), and a prominent lymphoid infiltrate. | File:Histopathology of medullary breast carcinoma.jpg |
| Solid papillary carcinoma | Larger tumor nests with fibrovascular cores. | File:Histopathology of solid papillary carcinoma.jpg |
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Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Tavassoli, F.A., ed (2003). World Health Organization Classification of Tumours: Pathology & Genetics: Tumours of the breast and female genital organs . Lyon: IARC Press. ISBN 978-92-832-2412-9.
- ↑ . Fibroadenoma of the breast.
- ↑ Richard L Kempson MD, Robert V Rouse MD. Fibroadenoma of the Breast. Stanford University School of Medicine. May 27, 2006
- ↑ Peter Abdelmessieh. Breast Cancer Histology. Medscape. Retrieved on 2019-10-04. Updated: May 24, 2018
- ↑ Siziopikou, Kalliopi P. (2013). "Ductal Carcinoma In Situ of the Breast: Current Concepts and Future Directions ". Archives of Pathology & Laboratory Medicine 137 (4): 462–466. doi:. ISSN 0003-9985.
- ↑ 6.0 6.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
Image sources