Basal-cell carcinoma
Author:
Mikael Häggström [note 1]
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Fixation
- Generally: Buffered 4% formaldehyde.[1]
Microscopic evaluation
Characteristics
Aggregates of basaloid cells with well-defined borders, showing a peripheral palisading of cells and a typical cleft.[2] Central necrosis with eosinophilic, granular features may be also present, as well as mucin. The heavy aggregates of mucin determine a cystic structure. Calcification may be also present, especially in long-standing lesions.[2] Mitotic activity is usually not so evident, but a high mitotic rate may be present in more aggressive lesions.[2] Adenoidal BCC can be classified as a variant of NBCC, characterized by basaloid cells with a reticulated configuration extending into the dermis.[2]
Differential diagnoses
| Differential diagnosis | Pathological Features |
|---|---|
| Tricoblastoma | Absence of cleft, rudimentary hair germs, papillary mesenchymal bodies. |
| Adenoid cystic carcinoma | Lack of basaloid cells disposed in peripheral palisades; adenoid-cystic lesion without connection to the epidermis; absence of artefactual clefts |
| Microcystic adnexal carcinoma | Bland keratinocytes, keratin cysts, ductal differentiation CEA+, EMA+ and BerEp4- |
| Tricoepithelioma[notes 1] | Rims of collagen bundles, calcification, follicular/sebaceous/infundibular differentiation and cut artefacts. Cytokeratin (CK)20+, p75+, Pleckstrin homology-like domain family A member 1 + (PHLDA1+), common acute lymphoblastic leukemiaantigen + (CD10+) in tumor stroma, CK 6-, Ki-67- and Androgen Rceptor- (AR-) |
| Merkel cell carcinoma | Cells arranged in a diffuse, trabecular and/or nested pattern, involving also the subcutis. Mouse Anti-Cytokeratin (CAM) 5.2+, CK20+, S100-, human leukocyte common antigen- ( LCA-), thyroid transcription factor 1- (TTF1-) |
Notes
- ↑ Desmoplastic tricoepithelioma is particularly similar
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel. Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision. KVAST (Swedish Society of Pathology). Retrieved on 2019-09-09.
- ↑ 2.0 2.1 2.2 2.3 2.4 Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update
". Biomedicines 5 (4): 71. doi:. ISSN 2227-9059. Cite error: Invalid
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Image sources