Urothelial versus squamous-cell carcinoma

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Author: Mikael Häggström [note 1]

Gross processing

Microscopic examination

Urothelial carcinoma with squamous differentiation will have some urothelial carcinoma areas and some areas looking like squanous cell carcinoma.

  • Squamous cell carcinoma of the urinary bladder should not have areas appearing like urothelial carcinoma.

In uncertain cases, perform immunohistochemistry for S100P and GATA3, where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas (present in 9% and near-0%, respectively).[1]

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Gulmann, Christian; Paner, Gladell P.; Parakh, Rugvedita S.; Hansel, Donna E.; Shen, Steven S.; Ro, Jae Y.; Annaiah, Chandrakanth; Lopez-Beltran, Antonio; et al. (2013). "Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract ". Human Pathology 44 (2): 164–172. doi:10.1016/j.humpath.2012.05.018. ISSN 00468177. 

Image sources


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