Dermoid cyst
Author:
Mikael Häggström [note 1]
Fixation
Generally 10% neutral buffered formalin.
Gross processing
Example gross report:
| (Optionally: A. Labeled - __ The specimen is received in formalin and consists of) tan-pink to yellow cystic ovarian tissue measuring __ cm. The cyst lining reveals multiple patches of hair with associated greasy yellow keratinous material. Cross-sections show several plate-like areas of rubbery grey-white cartilage. Representative sections are submitted for microscopic examination in three cassettes. |
Tissue sampling
Generally sample approximately 3 cassettes in order to be able to rule out immature elements.
There is no need to sample by Rokitansky nodules as these do not have any significant risk of containing immature elements.
Microscopic evaluation
The main components are:
- Diagnosis as a teratoma
- Ruling out an immature teratoma, and thereby establishing a diagnosis as a "mature (cystic) teratoma"
Teratoma diagnosis
The diagnostic criterion is a well-differentiated components from at least two germ layers (ectoderm, mesoderm and/or endoderm).[1] Common representative tissues of these are:
- Ectoderm:
-
Epidermis (stratified) and epidermal appendages
-
Nervous tissue
- Mesoderm:
-
Cartilage
Striated muscle, smooth muscle
- Endoderm:
-
Respiratory epithelium (pseudostratified ciliated)
-
Pancreatic tissue
- Thyroid tissue
- Gastrointestinal mucosa
See also
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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References
Image sources