Reactive lymph node

Author: Mikael Häggström
A reactive lymph node (or reactive lymphadenopathy) is a lymph node pattern that is usually secondary to inflammation.

Gross examination

Grossing as per lymph nodes in general.

An unspecific gross sign of a reactive lymph node is enlargement. Further information: Lymph node

Microscopic examination

Microscopic signs of reactive lymphadenopathy:

• 
  Follicular hyperplasia. However, follicular lymphoma should be excluded. Further information: Follicular hyperplasia

• Paracortical hyperplasia with expansion of paracortical areas by a mixed infiltrate, often having a mottled appearance, and it usually has a concomitant reactive follicular hyperplasia. A T-cell lymphoma should be suspected if there is obliteration or marked diminution of the B-cell cortical region, or highly irregular or hyperchromatic nuclei.
• Unspecific hyperplasia: An unspecific pattern of lymph node enlargement, without atypical cells, in the lymphatic drainage direction from an inflamed area, may be diagnosed as "benign reactive lymph node".

Reporting

Reactive lymphadenopathy may be reported as:

((A. Labeled - ___. The specimen is received in formalin and consists of))((One (1))) reactive lymph node((, negative for metastatic carcinoma)). Notes Main page Main page of Patholines References Image sources