Follicular lymphoma

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Author: Mikael Häggström [note 1]

Microscopic evaluation

Usual follicular lymphoma has at least partial follicular (nodular) distribution.[1]

Differential diagnosis

  • Follicular hyperplasia, also having prominent follicular centers. Compared to follicular lymphoma, it is more prevalent at younger age, has lower follicular density (typically not having back-to-back arrangement) and not typically having diffuse nodal effacement.[2] Further information: Follicular hyperplasia

Grading

Follicular lymphoma is graded as follows:[3]

  • Grade 1: follicles have <5 centroblasts per high-power field (hpf).
  • Grade 2: follicles have 6 to 15 centroblasts per hpf.
  • Grade 3: follicles have >15 centroblasts per hpf.
    • Grade 3A: Grade 3 in which the follicles contain predominantly centrocytes.
    • Grade 3B: Grade 3 in which the follicles consist almost entirely of centroblasts.

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Mahsa Khanlari, M.D., Jennifer Chapman, M.D.. Lymphoma & related disorders - Mature B cell neoplasms - Follicular lymphoma - Follicular-usual. Topic Completed: 26 February 2020. Minor changes: 16 June 2021
  2. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named WeissO'Malley2013
  3. ↑ Weissmann, David. Follicular Lymphomas. University of Medicine and Dentistry of New Jersey.

Image sources


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