Pheochromocytoma
Author:
Mikael Häggström [note 1]
Gross processing
As per Adrenal tumors
Evaluation
Microscopy typically shows:[1]
- Architecture of nested (zellballen), trabecular or solid arrangement of tumor cells
- Tumor cells being large, polygonal, uniform or extensively vacuolated
- Cytoplasm being abundant fine, granular and red-purple
Further workup
For a diagnosis of pheochromocytoma, look for any adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures.
Example report
| Right adrenal gland, resection: Adrenal pheochromocytoma (3.0 cm tumor). Surgical margins are negative for neoplasia. (Optionally: Comment: This adrenal pheochromocytoma exhibits no adverse histopathologic features such as vascular or capsular invasion, diffuse growth pattern, necrosis, increased mitotic activity or atypical mitotic figures. Nonetheless, metastatic potential is difficult to predict based on histologic parameters.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Katherine A. Lehman, B.S., Debra L. Zynger, M.D.. Adrenal gland & paraganglia - Pheochromocytoma / paraganglioma - Pheochromocytoma. Pathology Outlines. Topic Completed: 20 August 2021. Minor changes: 20 August 2021
Image sources