Duodenum
Author:
Mikael Häggström [note 1]
| Mostly: |
Common requests
Microscopic examination
Generally look for:
- Signs of peptic duodenitis
- Intra-epithelial lymphocytes
- Tumors
Peptic duodenitis
Peptic duodenitis typically showing the following:[1]
-
Brunner gland hyperplasia shows as Brunner glands above the muscularis mucosae.
Others
-
Intra-epithelial lymphocytes (IELs) is the main finding in celiac disease (even in earliest stage)[2].[images 1]
25 - 29 IEL/100 enterocytes is considered borderline.[3]
> 30 IEL/100 enterocytes represents a pathological lymphocytosis.[3] -
Tumors (leiomyoma pictured): evaluate as per intestine with tumor
![Intra-epithelial lymphocytes (IELs) is the main finding in celiac disease (even in earliest stage)[2].[images 1] 25 - 29 IEL/100 enterocytes is considered borderline.[3] > 30 IEL/100 enterocytes represents a pathological lymphocytosis.[3]](/index.php?title=Special:Upload&wpDestFile=Histopathology_of_duodenal_intra-epithelial_lymphocytes.jpg){kind=link}
Report
Example in a normal case:
| (Duodenum, biopsy:) Duodenal mucosa without significant histopathologic changes. (Negative for celiac disease.) |
Example in (chronic) peptic duodenitis:
| (Small bowel, biopsy:) Small intestinal mucosa with histologic changes consistent with chronic peptic duodenitis. (Negative for celiac disease.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Hasan Samra, M.D., Mohamed Mostafa, M.D.. Small intestine & ampulla - Inflammatory disorders - Peptic duodenitis. Pathology Outlines. Topic Completed: 13 April 2020. Minor changes: 13 April 2020
- ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') ". Gastroenterology 102 (1): 330–54. 1992. doi:. PMID 1727768.
- ↑ 3.0 3.1 Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.. Small intestine & ampulla. Malabsorption. Celiac sprue. Pathology Outlines. Retrieved on 2022-04-04.
Image sources
- ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')
". Gastroenterology 102 (1): 330–54. 1992. doi:. PMID 1727768.
- Figure 2- available via license: Creative Commons Attribution 2.0 Generic license.